Anxiety, depression and personality traits in severe, prednisone-dependent asthma

Amelink, Marijke; Hashimoto, Simone; Spinhoven, Philip; Pasma, Henk; Sterk, Peter J.; Bel, Elisabeth H.; Brinke, Anneke ten

doi:10.1016/j.rmed.2013.12.012

Cited by 59 publications

(37 citation statements)

References 44 publications

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“…10,11,28,29 Studies in patients with asthma, including severe asthma, that used the HADS, found rates of depression and anxiety to be 9% to 14% and 11% to 37%, respectively, 29,[30][31][32] which are lower than the prevalence rates found in participants with asthma and insomnia. The AQLQ score in participants with asthma and no insomnia were similar to the score found in a population-based study of 864 adults with asthma.…”

Section: Discussionmentioning

confidence: 99%

Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III

Luyster

Strollo

Holguin

et al. 2016

Chest

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BACKGROUND: Sleep difficulties are commonly reported by patients with asthma; however, the prevalence of insomnia and its association with disease burden and well-being is unknown. We aimed to determine the prevalence of insomnia, defined as combined sleep-specific complaints with associated daytime symptoms, among a large sample of adults with asthma, and to compare well-being, asthma control, and asthma-related health care utilization in individuals with asthma and insomnia and those without insomnia.

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Section: Discussionmentioning

confidence: 99%

Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III

Luyster

Strollo

Holguin

et al. 2016

Chest

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“…On the contrary, another study 32 reported that there was no association between IgE levels and symptoms of anxiety and depression in 374 women of the general population. Amelink et al 33 found that the patients with severe and prednisone-dependent asthma had more significant depressive and anxiety symptoms than patients with severe noneprednisone-dependent or mild-moderate asthma. Coogan et al 34 found that the incidence rate ratio of adult-onset asthma in African American women was higher in women who took antidepressants and that there was a positive association between the Center for Epidemiological Studies-Depression scale score and the incidence of adult-onset asthma.…”

Section: Discussionmentioning

confidence: 99%

The impact of anxiety and depression on outpatients with asthma

Ciprandi

Schiavetti

Rindone

et al. 2015

Annals of Allergy, Asthma & Immunology

148

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“…Patients with eosinophilic inflammation generally respond well to inhaled corticosteroid. However, some patients also require oral corticosteroids, which may be associated with adverse events [24–26]. Treatments targeting eosinophils may improve asthma control [27].…”

Section: Introductionmentioning

confidence: 99%

Health care resource utilization and characteristics of patients with eosinophilic asthma in secondary health care in Finland

Mäkelä

Christensen

Karlsson

et al. 2018

European Clinical Respiratory Journal

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Background: Eosinophilic airway inflammation is common in asthma patients and appears to be associated with severe exacerbations and loss of asthma control. Objective: To describe the resource utilization and clinical characteristics of patients with eosinophilic asthma. Design: Asthma patients ≥18 years with ≥1 blood eosinophil count in secondary care (South West Finland) during 2003‒2013 were included. Clinical characteristics (age, lung function, body mass index, and comorbidities) and asthma-related resource utilization (hospital admissions, outpatient visits, and emergency room [ER] visits) were retrieved. Resource utilization rates were compared for patients with blood eosinophil ≤ or >300 cells/μL, using adjusted negative binomial regression models. Results: Overall, 4,357 eligible patients were identified (mean age 60 years, females 68%), of which 1,927 (44%) had >300 eosinophil cells/μL blood. Patients with ≤300 and >300 eosinophil counts, exhibited similar clinical characteristics, including advanced age, poor lung function, and overweight. Comorbidities such as pneumonia, sinusitis, and nasal polyps, were more frequent among those with >300 eosinophil cells/μL blood compared with patients with lower counts. Eosinophil counts >300 cells/μL were associated with greater hospital admissions (rate ratio [RR] [95% confidence interval CI]: 1.13 [1.02;1.24]) and outpatient visits (RR [95% CI]: 1.11 [1.03;1.20]) compared with patients with lower eosinophil counts. Rates of ER visits were similar between the patient groups (RR [95% CI]: 0.99 [0.87;1.12]). Conclusions: Hospital admissions and outpatient visits occurred more often for patients with eosinophil counts >300 cells/µL, than for patients with lower eosinophil counts. Routine blood eosinophil screening might be useful to identify patients with an eosinophilic phenotype eligible for more targeted treatments.

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Anxiety, depression and personality traits in severe, prednisone-dependent asthma

Abstract: Patients with severe, prednisone-dependent asthma have more often psychological distress as compared to patients with severe non-prednisone dependent or mild-moderate asthma.

Cited by 59 publications

References 44 publications

Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III

Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III

The impact of anxiety and depression on outpatients with asthma

Health care resource utilization and characteristics of patients with eosinophilic asthma in secondary health care in Finland

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