Anxiety and the risk of death in older men and women

Hout, Hein van; Beekman, Aartjan T.F.; Beurs, Edwin de; Comijs, Hannie C.; Marwijk, Harm van; Haan, Marten de; Tilburg, W. van; Deeg, Dorly J. H.

doi:10.1192/bjp.185.5.399

Cited by 117 publications

(84 citation statements)

References 33 publications

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“…Other studies found an increased mortality risk for anxiety disorders in men but not in women (Van Hout et al, 2004). However, in this study the mortality risk was ascertained for all anxiety disorders whereas in our study specific generalized anxiety was investigated.…”

Section: Main Findingsmentioning

confidence: 67%

The relationship between generalized anxiety disorder, depression and mortality in old age

Holwerda

Schoevers

Dekker³

et al. 2006

Int J Geriat Psychiatry

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SUMMARYBackground The association between depression and an increased risk of death in elderly persons has been established in both clinical and community studies. Co-occurrence of depression and generalized anxiety has been shown to represent more severe and more chronic psychopathology. However, little is known about the relation between generalized anxiety disorder, mixed anxiety-depression (generalized anxiety disorder and depression) and excess mortality in the elderly. Objective To investigate whether generalized anxiety and mixed anxiety-depression are associated with mortality. Method Generalized anxiety disorder, mixed anxiety-depression and depression were assessed in 4051 older persons with a ten-year follow-up of community death registers. The mortality risk of generalized anxiety, depression and mixed anxietydepression was calculated after adjustment for demographic variables, physical illness, functional disabilities and social vulnerability. Results In generalized anxiety disorder and mixed anxiety-depression no significant excess mortality was found. In depression a significant excess mortality was found in men [HR 1.44 (1.09-1.89)] but not in women [HR 1.04 (0.87-1.24)] after adjustment for the different variables. Conclusions In elderly persons depression increases the risk of death in men. Neither generalized anxiety nor mixed anxiety-depression are associated with excess mortality. Generalized anxiety disorder may even predict less mortality in depressive elderly people. The relation between generalized anxiety disorder and its possibly protective effect on mortality has to be further explored.

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Section: Main Findingsmentioning

confidence: 67%

The relationship between generalized anxiety disorder, depression and mortality in old age

Holwerda

Schoevers

Dekker³

et al. 2006

Int J Geriat Psychiatry

Self Cite

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show abstract

“…However, this discrepancy might be due to the difference in populations examined: older adults (18) and the general population (19). It is also possible that anxiety may only predict mortality in men, as in one previous study where an association between anxiety disorders and mortality was found for men but not women (42). GAD has not been previously studied in terms of CVD mortality in the general population, or in the context of mortality per se in veterans.…”

Section: Discussionmentioning

confidence: 94%

Generalized Anxiety Disorder, Major Depressive Disorder, and Their Comorbidity as Predictors of All-Cause and Cardiovascular Mortality: The Vietnam Experience Study

Phillips

Batty

Gale

et al. 2009

Psychosomatic Medicine

157

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“…Although anxiety was significantly associated with three of the four individual QOL domains, depression was only significantly associated with one domain (environmental). Certainly, there is prior research to suggest that comorbid anxiety in people with depression can worsen overall psychopathology and QOL [5,6,11]; however, there has been little investigation of the relative impact of each of these disorders individually on QOL. Although limited by a small sample size, these results raise the question of whether anxiety symptomatology may have a more significant impact on QOL than depressive symptomatology has on QOL.…”

Section: Discussionmentioning

confidence: 99%

“…These patients have more somatic symptoms, poorer social function and greater suicidal ideation than non-anxious depressed patients. Late-life anxiety has also been associated with increased disability, increased mortality rates [6] and decreased QOL [7][8][9]. It is also associated with increased utilisation of primary care services, even when controlling for physical health status [10] and depressive comorbidity [11].…”

Section: Introductionmentioning

confidence: 99%

Relationship between anxiety and quality of life in older mental health patients

Sarma

Byrne

2013

Australas J Ageing

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AimThis study aims to investigate the impact of anxiety on quality of life (QOL) in older people with mental disorders.MethodForty patients from a district Older Persons Mental Health Service were assessed using the Mini‐International Neuropsychiatric Interview (MINI‐5). They then completed the brief version of the World Health Organization Quality of Life Scale (WHOQOL‐BREF), Geriatric Anxiety Inventory and Geriatric Depression Scale.ResultsSelf‐reported anxiety was significantly associated with reduced overall QOL on the WHOQOL‐BREF. Anxiety was also associated with the psychological, social and environmental domains of the WHOQOL‐BREF, but not with the physical health domain. Anxiety was correlated with more individual domains of QOL than depression.ConclusionsAnxiety makes a significant contribution to self‐rated QOL in older people with serious mental disorders.

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Anxiety and the risk of death in older men and women

Abstract: The study revealed a gender difference in the association between anxiety and mortality. For men, but not for women, an increased mortality risk was found for anxiety disorders.

Cited by 117 publications

References 33 publications

The relationship between generalized anxiety disorder, depression and mortality in old age

The relationship between generalized anxiety disorder, depression and mortality in old age

Generalized Anxiety Disorder, Major Depressive Disorder, and Their Comorbidity as Predictors of All-Cause and Cardiovascular Mortality: The Vietnam Experience Study

Relationship between anxiety and quality of life in older mental health patients

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