Anxiety and salivary cortisol in symptomatic and nonsymptomatic panic patients and healthy volunteers performing simulated public speaking

Garcia-Leal, Cybele; Parente, Alexandre Castelo Branco Vaz; Del-Ben, Cristina Marta; Guimarães, Francisco Silveira; Moreira, Ayrton Custódio; Elias, Lucila Leico Kagohara; Graeff, Frederico Guilherme

doi:10.1016/j.psychres.2004.04.010

Cited by 59 publications

(48 citation statements)

References 70 publications

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“…In the present study there were no significant differences in anxietyTrait Anxiety nor the State when the groups were compared. A likely explanation is the fact that of the little sensitivity by the scale effects of anxiolytic drugs [16]. In this study, using the Passiflora incarnata L., there was a reduction in heart rate (HR) during the whole speech in the experimental group with single administration, but not in multiple doses.…”

Section: Discussionmentioning

confidence: 63%

“…The electrical conductance skin (ECS) did not change in any of the tests, even though the changes in the emotional state causes neurovegetative changes, for example, increase the activity of the sweat glands innervated by cholinergic fibers of the Central Nervous System (CNS) [16]. Likewise the temperature of the extremities has not changed.…”

Section: Discussionmentioning

confidence: 94%

“…The induced anxiety and the effect produced by the substances used in the experiment can then be assessed using psychometric scales and physiological measurements [15,16]. The Table 1 shows the result of the experimental session.…”

Section: Methodsmentioning

confidence: 99%

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Effects of the single supplementation and multiple doses of Passiflora incarnata L. on human anxiety: A Clinical Trial, Double-blind, Placebo-controlled, Randomized

Silva¹,

Costa²,

Alves³

et al. 2017

int arch med

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Object: This study aimed to investigate the effects of Passiflora incarnata L. on anxiety in humans. Method:The individuals were randomly assigned to one of the following groups: Placebo or experimental, n =30, single dose, as well as Placebo or Experimental, n =15, multiple dose. The experimental human anxiety was induced by simulated public speaking test in the following phases: Basal (B), stressful (A), speech 1 (S1), speech 2 (S2) and Final (F). We evaluated the Systolic Blood Pressure (SBP), and Diastolic (DBP), Heart Rate (HR), Electrical Conductance of Skin and extremities temperature (ET) and filled The state-trait anxiety inventory (STAI S e T).Results: During the single dose, the HR was reduced at the end of the speech (86±2.0 to 74±3.0 bpm) the experimental group compared to the placebo group (p<0.05); the STAI-S did not change. In the delineation of multiple doses, SBP was reduced, in mmHg, in the experimental group compared to the placebo group during all phases. Experimental: 106±1.0 (B), 111±1.0 (A), 121±2.0 (S1), 115±3 (S2), 104±2.0 (F) IntroductionAnxiety disorders reach over 25% prevalence, including the fear of public speaking [1]. Anxiety comprises emotional and behavioral factors through fear manifestation, insecurity, apprehensive anticipation, catastrophic thinking, increase in wakefulness or alert period and physiological, as activation of the hypothalamic-pituitary-adrenal (HPA) axis, leading neurovegetative symptoms such as insomnia, tachycardia, pallor, increased perspiration, muscle tension, trembling, dizziness, intestinal disorders, among others [2].The impact of anxiety on the individuals's health covers changes in blood pressure, heart rate and an increased risk of cardiovascular diseases such as coronary heart disease (risk tripled) and cerebrovascular [3].Therefore, researchers have invested in as natural forms taken to treat or ameliorate the symptoms of anxiety, such as the use of herbs. Plants that are most studied with anxiolytic potential are Kawa, the St. John's Wort and Passiflora spp. [4][5][6][7]. The Passiflora extract has been used in many researches, presenting in their chemical constitution polyphenols, polyunsaturated fatty acids, fiber and other substances, such as passiflorin, one indole alkaloid, being the last one associated with anxiolytic effects [3].The effects of Passiflora incarnata L on anxiety was previously assessed in animals [8,4] and in humans [9-10] with satisfactory results [7]. Epidemiological studies have shown that the fear of public speaking is one of the biggest phobias that affect people, being highly prevalent among students [11].The study proposal was to evaluate symptoms of anxiety of public speaking, under a single dose and multiple doses through the simulated public speaking (SPS) test through the intervention with the encapsulated dry extract of the whole plant Passiflora incarnata L. Materials and MethodsSubjects A study population consisted of university students, adults, healthy, between 24 and 31 years, of both sexes, wer...

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 94%

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Effects of the single supplementation and multiple doses of Passiflora incarnata L. on human anxiety: A Clinical Trial, Double-blind, Placebo-controlled, Randomized

Silva¹,

Costa²,

Alves³

et al. 2017

int arch med

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show abstract

“…Recently, Petrowski et al (2010) reported a blunted cortisol response to moderate or intense psychosocial stress in a group of patients with panic disorder. Other studies also reported a hypo-or nonresponsiveness to stress in patients with panic disorder (Leyton et al, 1996;Hoehn et al, 1997;Garcia-Leal et al, 2005). sAA and salivary cortisol levels might differ according to the length of time a study participant had been in the hospital (Balodis et al, 2010).…”

Section: Panic Disorder and Salivary Amylasementioning

confidence: 97%

Acute Stress in Patients with Panic Disorder Produces Effects on Salivary Amylase and Cortisol

Akiyoshi¹,

Isogawa²,

Ishitobi³

et al. 2011

Different Views of Anxiety Disorders

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“…Os resultados obtidos nos diversos estudos têm conseguido demonstrar o efeito ansiolítico de diversos psicofármacos, como por exemplo o canabidiol (ZUARDI et al,46 1993), a d-fenfluramina (HETEM et al, 1996), a ritanserina (GUIMARÃES et al, 1997) e a ocitocina (CHAVES, 2007), bem como o entendimento dos mecanismos mentais e biológicos envolvidos nos transtornos psiquiátricos, sobretudo no Transtorno do Pânico (DEL-BEN et al, 2001b;GARCIA-LEAL et al, 2005;PARENTE et al, 2005), referendando a eficácia e validade do modelo experimental.…”

Section: O Transtorno De Ansiedade Social E O Medo De Falar Em Públicounclassified

Transtorno de ansiedade social: validação de instrumentos de avaliação

Osório¹,

Loureiro²,

Crippa³

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À Profa. Dra. Marisa Japur, com quem tive a honra de realizar minha iniciação científica, ainda na Graduação em Psicologia, sendo apresentada de forma apaixonante, séria e ética ao mundo da pesquisa científica;Aos colegas da Pós-graduação: Carlos Alberto Baptista, Alaor Santos Filho, Maria Cecília Freitas,Carolina Menezes Gaya, Luciene Vaccaro de Moraes, Kátia Regina Busato, Clarissa Trzesniak, Stella Mesquita, Moisés Chaves, Luiz Márcio Lima, Maria Gabriela

show abstract

Anxiety and salivary cortisol in symptomatic and nonsymptomatic panic patients and healthy volunteers performing simulated public speaking

Cited by 59 publications

References 70 publications

Effects of the single supplementation and multiple doses of Passiflora incarnata L. on human anxiety: A Clinical Trial, Double-blind, Placebo-controlled, Randomized

Effects of the single supplementation and multiple doses of Passiflora incarnata L. on human anxiety: A Clinical Trial, Double-blind, Placebo-controlled, Randomized

Acute Stress in Patients with Panic Disorder Produces Effects on Salivary Amylase and Cortisol

Transtorno de ansiedade social: validação de instrumentos de avaliação

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