Anxiety and risk of dementia: Systematic review and meta-analysis of prospective cohort studies

Santabárbara, Javier; Lipnicki, Darren M.; Villagrasa, Beatriz; Lobo, Elena; López-Antón, Raúl

doi:10.1016/j.maturitas.2018.10.014

Cited by 40 publications

(24 citation statements)

References 41 publications

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“…This current work extends the findings of our previous meta-analysis [15] by including three new cohort studies [16][17][18] that yielded a sample of 29,608 older adults without dementia at baseline. The association between anxiety and an increased risk of all-cause dementia reported here is consistent with our previous meta-analysis, and with other studies [12,14,15]. Our current findings also complement the study by Gulpers et al by providing the PAF of dementia due to anxiety.…”

Section: Comparison With Previous Studiessupporting

confidence: 74%

“…The risk estimation found by Gulpers et al [14] was twice as high as what we found in this study and our previous meta-analysis [15]. The main reason for this difference could be that three out of six community samples investigated by Gulpers et al were comprised entirely of individuals with mild cognitive impairment at baseline, and who might have a higher risk of conversion to dementia than cognitively intact subjects [37].…”

Section: Comparison With Previous Studiescontrasting

confidence: 66%

“…However, this meta-analysis included both cognitively healthy samples as well as samples with mild cognitive impairment. In a previous meta-analysis exclusively using population-based cohort studies with cognitively intact participants [15], we found that anxiety conveyed a 29% increased risk of dementia.…”

Section: Introductionmentioning

confidence: 81%

“…Briefly, the search strategy included the following terms: (anxiety AND Dementia AND (cohort study OR longitudinal study OR incidence)) using both medical subject headings and free text ( Supplementary Table S1). We only considered studies written in English and published after January 2018 to avoid overlap with our previous meta-analysis [15]. We also focused on prospective population-based studies with baseline assessment of anxiety in cognitively intact subjects who were re-evaluated at follow-up for incident all-cause dementia.…”

Section: Search Strategy and Selection Criteriamentioning

confidence: 99%

“…After reading the full text of 14 articles, only three were finally selected. Additionally, the five studies from our previous systematic review were included [15].…”

Section: Study Selectionmentioning

confidence: 99%

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Does Anxiety Increase the Risk of all-Cause Dementia? An Updated Meta-Analysis of Prospective Cohort Studies

Santabárbara

Lipnicki

Olaya

et al. 2020

JCM

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Background: Anxiety has been suggested as a potentially modifiable risk factor for dementia, but results are still controversial. Our main objectives are to develop an updated meta-analysis of prospective population-based studies on the relationship between anxiety and risk of dementia, and to estimate the population fraction of dementia attributable to anxiety (PAF). Methods: We searched for cohort studies listed on PubMed or Web of Science from January 2018 to January 2020 that reported risk estimates for the association between anxiety and incident dementia. These were added to cohort studies published before January 2018 that were used in a previously published meta-analysis. Fully adjusted RRs were pooled using random effects models. We estimated the proportion of incident dementia attributable to anxiety by using PAF. Results: The meta-analysis included nine prospective cohorts from eight studies, representing 29,608 participants. The overall relative risk (RR) of dementia was 1.24 (95% CI: 1.06–1.46) and the PAF of dementia due to anxiety was 3.9%. Conclusions: Anxiety is significantly associated with an increased risk of all-cause dementia. The treatment or prevention of anxiety might help to reduce dementia incidence rates, but more research is needed to clarify whether anxiety is a cause of dementia rather than a prodrome.

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Section: Comparison With Previous Studiessupporting

confidence: 74%

Section: Comparison With Previous Studiescontrasting

confidence: 66%

Section: Introductionmentioning

confidence: 81%

Section: Search Strategy and Selection Criteriamentioning

confidence: 99%

“…After reading the full text of 14 articles, only three were finally selected. Additionally, the five studies from our previous systematic review were included [15].…”

Section: Study Selectionmentioning

confidence: 99%

See 3 more Smart Citations