Anxiety and depression in patients with advanced ovarian cancer: a prospective study

Mielcarek, P.; Nowicka-Sauer, Katarzyna; Kozaka, Joanna

doi:10.3109/0167482x.2016.1141891

Cited by 44 publications

(34 citation statements)

References 32 publications

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“…8 Moreover, the administration of chemotherapy increases maternal stress. 17 In our series, four patients received chemotherapy during pregnancy. However, only one livebirth was recorded.…”

Section: Discussionmentioning

confidence: 85%

<p>Clinicopathological Characteristics and Treatment Outcomes of Pregnancy Complicated by Malignant Ovarian Germ Cell Tumors</p>

Zong¹,

Yang²,

Zhang³

et al. 2020

CMAR

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Purpose: This study aimed to analyze the clinicopathological features, treatment, and fetomaternal outcomes of pregnancy complicated by malignant ovarian germ cell tumors (MOGCTs), to increase the awareness on this condition. Patients and Methods: We retrospectively reviewed the medical records of patients diagnosed with MOGCTs during pregnancy, who were treated and followed-up at Peking Union Medical College Hospital from January 2000 to December 2017. The demographic characteristics, pathological features, treatment and prognosis were analyzed. Results: The histological subtypes varied in 14 patients (dysgerminoma, n=1; immature teratoma, n=4; yolk sac tumor, n=6; and mixed germ cell tumors, n=3). Ten (71.4%) patients, including three who opted for conservative therapy until childbirth, one who only received salvage chemotherapy during pregnancy, and six who underwent cystectomy or unilateral salpingo-oophorectomy during pregnancy, desired fetal preservation. After undergoing surgery, four patients chose surveillance instead of timely adjuvant chemotherapy. Eight patients delivered their babies, and the preterm delivery rate was 50.0%. One newborn died of premature birth. The median follow-up period was 44 (range: 13 to 86) months. During the current study period, 12 patients had survived and did not report any diseases. However, two died due to disease progression. Conclusion: Pregnant women with MOGCTs had favorable outcomes. However, when a malignant tumor is suspected, surgery cannot be avoided. Thus, instead of timely postoperative adjuvant chemotherapy, close surveillance may be an acceptable alternative for pregnant women with low-risk MOGCTs.

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“…8 Moreover, the administration of chemotherapy increases maternal stress. 17 In our series, four patients received chemotherapy during pregnancy. However, only one livebirth was recorded.…”

Section: Discussionmentioning

confidence: 85%

<p>Clinicopathological Characteristics and Treatment Outcomes of Pregnancy Complicated by Malignant Ovarian Germ Cell Tumors</p>

Zong¹,

Yang²,

Zhang³

et al. 2020

CMAR

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“…19 Patients might experience reduced stress levels as a result, considering the well-documented physical and psychological consequences of ovarian and of Li-Fraumeni-associated cancers. [20][21][22] Compared to other cancers (IDC included), ILC shows unusually high levels of familial clustering, pointing toward a major contribution of genetic, inherited factors to the disease. 23 Only one clinically relevant ILC-specific susceptibility gene, CDH1, has been identified so far.…”

Section: The Question Raised By Our Results Is Whether Brca1 and Tp53mentioning

confidence: 99%

“…Genetic counseling should be adapted accordingly, that is no mention of a possible >40% lifetime risk of ovarian cancer as seen with BRCA1 or of a potential risk of multiple cancers regardless of age as seen in Li‐Fraumeni syndrome . Patients might experience reduced stress levels as a result, considering the well‐documented physical and psychological consequences of ovarian and of Li‐Fraumeni‐associated cancers …”

Section: Discussionmentioning

confidence: 99%

Low risk of invasive lobular carcinoma of the breast in carriers of BRCA1 (hereditary breast and ovarian cancer) and TP53 (Li‐Fraumeni syndrome) germline mutations

et al. 2019

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Background Invasive lobular carcinoma (ILC) of the breast has epidemiological, molecular and clinical specificities, and should likely be considered a unique entity. As for genetic susceptibility, CDH1 germline mutations predispose exclusively to ILC. Data are however scarce regarding ILC in women with BRCA1/2 (Hereditary Breast and Ovarian Cancer) and TP53 (Li‐Fraumeni syndrome) germline mutations. Methods We included all breast cancers from female patients tested at our institute between 1992 and 2016 (n = 3469) for which pathology data were available. ILC proportion comparison according to mutational status was performed by a chi‐squared test. The impact of susceptibility genes on ILC proportion was investigated by univariate logistic regression with wild‐type patients as reference. Results and discussion There were 265 (7.64%) ILC: 2/342 (0.58%) in BRCA1 patients, 24/238 (10%) in BRCA2 patients, 1/57 (1.75%) in TP53 patients and 238/2832 (8.4%) in non‐carriers. The majority of breast cancers in all groups were invasive ductal and ductal in situ carcinomas. The difference in ILC proportion was highly significant (P < 0.001). Compared to wild‐type patients, BRCA1 was associated with a lower ILC proportion (OR 0.064 [95% CI 0.016;0.259], P < 0.0001). BRCA2 OR was 1.222 [95%CI 0.785;1.902] (P = 0.374), TP53 OR was 0.195 [95%CI 0.027;1.412] (P = 0.105). ILC are therefore underrepresented in BRCA1 and TP53 mutation carriers. Formal significance (P = 0.05) was not reached for TP53, but statistical power was only 38%. Based on ILC incidence in the general population, we make the hypothesis that BRCA1 and TP53 do not predispose to ILC, as the few occurrences of ILC in mutation carriers could be attributed to chance and not to germline mutations. Our observations will be useful to clinical cancer geneticists managing patients with ILC, as a BRCA1 or TP53 mutation in these patients would be unlikely. Genetic counseling should be adapted accordingly.

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“…Furthermore, according to the patients, side effects and long-term sequelae and restrictions were not discussed in most cases. There are several possible explanations for this: Patients may not have remembered all items discussed as the topics are complex and mental stress is highest before surgery [16,17,18]. Yet with less than one fifth of the participants reporting having received information about long-term morbidity, it is probable that a considerable part of the physicians concentrated on discussing more immediate problems.…”

Section: Discussionmentioning

confidence: 99%

Communication before Cancer Surgery - the Perspective of Patients with Gastrointestinal Cancer

Huebner

Keinki²,

Kleeberg³

et al. 2016

Oncol Res Treat

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Anxiety and depression in patients with advanced ovarian cancer: a prospective study

Cited by 44 publications

References 32 publications

<p>Clinicopathological Characteristics and Treatment Outcomes of Pregnancy Complicated by Malignant Ovarian Germ Cell Tumors</p>

<p>Clinicopathological Characteristics and Treatment Outcomes of Pregnancy Complicated by Malignant Ovarian Germ Cell Tumors</p>

Low risk of invasive lobular carcinoma of the breast in carriers of BRCA1 (hereditary breast and ovarian cancer) and TP53 (Li‐Fraumeni syndrome) germline mutations

Communication before Cancer Surgery - the Perspective of Patients with Gastrointestinal Cancer

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