Anxiety and depression among AL amyloidosis patients: the role of cardiac symptoms

Smorti, Martina; Cappelli, Francesco; Bergesio, Franco; Perfetto, Federico

doi:10.3109/13506129.2012.687420

Cited by 11 publications

(5 citation statements)

References 25 publications

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“…The ATTR form can be further classified in hereditary transthyretin‐related amyloidosis (ATTRm), due to mutations in the gene codifying for transthyretin, and systemic senile amyloidosis, a noninherited form caused by the deposition of the wild‐type transthyretin (TTR) protein (ATTRwt) in the extracellular space . Cardiac involvement is frequent in both AL and ATTR amyloidosis, and is associated with important clinical and psychological consequences that have a significant impact on prognosis…”

Section: Introductionmentioning

confidence: 99%

Echocardiographic and Biohumoral Characteristics in Patients With AL and TTR Amyloidosis at Diagnosis

Cappelli

Baldasseroni

Bergesio

et al. 2015

Clinical Cardiology

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Background: Few studies have analyzed the clinical and echocardiographic differences between light-chain (AL) and transthyretin (TTR) amyloidosis. Hypothesis: The aim of the present research was to compare, in a real-world setting, the clinical and echocardiographic profiles of these kinds of amyloidosis, at the time of diagnosis, using new-generation echocardiography. Methods: Seventy-nine patients with AL and 48 patients with TTR amyloidosis were studied. Results: According to the criterion of mean left ventricular (LV) thickness >12 mm, 45 AL (C-AL) and all TTR patients had cardiac amyloidotic involvement, whereas 34 AL patients did not. TTR patients had increased right ventricular (RV) and LV chambers with increased RV and LV wall thickness and reduced LV ejection fraction and fractional shortening. Furthermore, TTR patients showed lower N-terminal pro Brain Natriuretic Peptide concentrations and New York Heart Association functional class when compared with C-AL. Conclusions: Our data show that at time of first diagnosis, TTR patients have a more advanced amyloidotic involvement of the heart, despite less severe symptoms and biohumoral signs of heart failure. We can hypothesize that we observed different diseases at different stages. In fact, AL amyloidosis is a multiorgan disease with quick progression rate, that becomes rapidly symptomatic, whereas TTR amyloidosis might have a slow progression rate and might remain poorly symptomatic for a greater amount of time.

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Section: Introductionmentioning

confidence: 99%

Echocardiographic and Biohumoral Characteristics in Patients With AL and TTR Amyloidosis at Diagnosis

Cappelli

Baldasseroni

Bergesio

et al. 2015

Clinical Cardiology

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“…Previous studies conducted in AL amyloidosis, a disease with a different systemic involvement, age of onset, and therapeutic approach, showed that anxiety and depression were common, reported in approximately 30% of subjects ( Smorti et al, 2012 , 2014 , 2016 ; Lo et al, 2015 ; Shu et al, 2016 ; Lopes et al, 2018 ). Moreover, Smorti et al found that time since the onset of cardiac symptoms was a positive predictor of anxiety in AL patients, whereas only the severity of cardiac symptoms was for depression ( Smorti et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of anxiety and depression symptoms in a sample of outpatients with ATTR cardiac amyloidosis

et al. 2023

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Patients with ATTR cardiac amyloidosis (ATTR-CA) face rare disease that could negatively influence psychological well-being with consequences on the course of the disease and quality of life. However, to date, no study analyzed the prevalence of anxiety and depression in patients with ATTR-CA and which clinical and sociodemographic characteristics are linked with these psychopathological conditions. A total of 109 consecutive patients (83% males) aged 62–90 years with ATTR-CA were recruited. In order to better understand the prevalence of anxiety and depression in ATTR-CA, a control group composed by 33 individuals equaling gender, education, and age were recruited. The level of anxiety and depression was measured using the Italian version of the Hospital Anxiety and Depression Scale (HADS). Sociodemographic and clinic characteristics were registered. Almost half of patients (49%) reported a clinical level of depression or anxiety, or both. ATTR-CA patients reported higher levels of anxiety and depression than control group. Results showed that older patients with ATTR-CA, especially females, with more advanced disease could be more at risk to develop an anxious disorder. Furthermore, being a woman, and presenting with a greater severity of symptoms, would appear to be a risk factor for developing a depressive disorder. Overall, these results highlighted the high presence of anxiety and depression in ATTR-CA patients, suggesting to physicians to pay attention to the psychological well-being of ATTR-CA patients. In fact, a psychological support for patients with high level of psychopathological disease could reduce disease burden and improve quality of life in ATTR-CA population.

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“…1 Findings from our own research group have suggested that anxiety and depressive problems are common among AL CA patients and that they are related to cardiac symptom severity and thus contribute to the worsening of individuals' health status. 3,4 In particular, anxiety and depression in AL CA patients are linked to the worsening of cardiac symptoms over time. In other words, patients with worse symptoms have reported higher levels of anxiety and depression compared to those with less severe symptomatology, in line with previous research on cardiac patients.…”

Section: Introductionmentioning

confidence: 99%

“…In other words, patients with worse symptoms have reported higher levels of anxiety and depression compared to those with less severe symptomatology, in line with previous research on cardiac patients. 3,[5][6][7][8] Nevertheless, health has been defined as 'a state of complete physical, mental, and social well-being' 9 and not just the absence of disease. In the context of this expanded definition of health, satisfaction with life is emerging as an important issue for understanding the nature of psychological disorders and their impact on life.…”

Section: Introductionmentioning

confidence: 99%

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Anxiety and depression among amyloid light-chain cardiac amyloidosis patients: The role of life satisfaction

Smorti

Guarnieri

Bergesio³

et al. 2015

European Journal of Cardiovascular Nursing

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Anxiety and depression among AL amyloidosis patients: the role of cardiac symptoms

Abstract: Our results suggest that there is a need to plan psychological support for these patients with consideration for the onset of cardiac symptoms and symptom severity.

Cited by 11 publications

References 25 publications

Echocardiographic and Biohumoral Characteristics in Patients With AL and TTR Amyloidosis at Diagnosis

Echocardiographic and Biohumoral Characteristics in Patients With AL and TTR Amyloidosis at Diagnosis

Prevalence of anxiety and depression symptoms in a sample of outpatients with ATTR cardiac amyloidosis

Anxiety and depression among amyloid light-chain cardiac amyloidosis patients: The role of life satisfaction

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