Anxiety and depression among amyloid light-chain cardiac amyloidosis patients: The role of life satisfaction

Smorti, Martina; Guarnieri, Silvia; Bergesio, Franco; Perfetto, Federico; Cappelli, Francesco

doi:10.1177/1474515114566737

Cited by 12 publications

(10 citation statements)

References 21 publications

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“…Among patients with cardiovascular disease, a significant correlation between life satisfaction and depression has been established (Steca et al, 2013). A study of amyloid light-chain cardiac amyloidosis has shown the association between depression and anxiety and life satisfaction (Smorti et al, 2016). Life satisfaction, the general affective evaluation of a person’s life (Pavot et al, 1991), is an important component of subjective well-being (Yang & Srinivasan, 2016).…”

Section: Introductionmentioning

confidence: 99%

Influence of Life Satisfaction on Quality of Life: Mediating Roles of Depression and Anxiety Among Cardiovascular Disease Patients

et al. 2020

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The present study aimed to determine the mediating effects of depression and anxiety on the association between life satisfaction and quality of life. We used the Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder Scale (GAD-7), and EuroQol Five Dimensions Questionnaire (EQ-5D) to measure depression, anxiety, and quality of life, respectively. A single question was used to measure the life satisfaction of participants. Life satisfaction was significantly related with depression ( r = −0.17), anxiety ( r = −0.18), and quality of life ( r = 0.19). Depression and anxiety were also related to quality of life. Depression and anxiety had full mediating effects (β = −0.274; β = −0.208) on the association between life satisfaction and quality of life. For those with poor life satisfaction, people were more likely to have high level of depression and anxiety, which in turn experienced poor quality of life.

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Section: Introductionmentioning

confidence: 99%

Influence of Life Satisfaction on Quality of Life: Mediating Roles of Depression and Anxiety Among Cardiovascular Disease Patients

et al. 2020

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“…Qualitative research indicates that patients with AL amyloidosis experience substantial burden that can lead to impairment in daily functioning [10, 11]. Furthermore, AL amyloidosis can lead to anxiety, frustration, and depression as patients grapple with the gravity and rarity of their condition [10, 12]. Although limited, quantitative studies provide evidence of deficits in both physical and mental aspects of HRQoL [13, 14].…”

Section: Introductionmentioning

confidence: 99%

The burden of amyloid light chain amyloidosis on health-related quality of life

Bayliss

McCausland

Guthrie

et al. 2017

Orphanet J Rare Dis

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BackgroundLight chain (AL) amyloidosis is a rare disease characterized by misfolded amyloid protein deposits in tissues and vital organs, and little is known about the burden of AL amyloidosis on health-related quality of life. This study aimed to quantify the burden of AL amyloidosis in terms of health-related quality of life in a diverse, community-based sample of AL amyloidosis patients.ResultsThe SF-36v2® Health Survey (SF-36v2), a widely used generic measure of health-related quality of life (using physical and mental summary scales and subscales assessing eight aspects of functioning and well-being), was administered as an online survey of AL amyloidosis patients with AL amyloidosis (ClinicalTrials.gov, NCT02574676; n = 341). Compared with adjusted general population sample norms, health-related quality of life of AL amyloidosis patients was significantly worse across all SF-36v2 scales and summary measures based on analysis of variance (p < 0.05 for all). The largest decrement in AL amyloidosis patients was related to General Health (Δ = 9.7; p < 0.001). With the exception of Bodily Pain and Mental Health, differences were also clinically meaningful based on established clinically minimal important differences. The burden of AL amyloidosis overall and in key subgroups tended to be greater on physical health than on mental health. Stratified analyses indicated additional burden among patients with recently diagnosed disease and those with cardiac involvement than among their respective counterparts.ConclusionUnderstanding the burden of AL amyloidosis highlights the unmet need for treatment, helps physicians identify ancillary treatments and services geared towards improving patients’ functioning, well-being, and overall health-related quality of life. These findings also help to support the use of health-related quality of life end points as important outcome measures in current and future treatment studies.Trial registrationClinicalTrials.gov, NCT02574676. Registered October 5, 2015.

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“…In conclusion, the results of the current study provided evidence of the content validity of the SF-36v2 as an appropriate measure for assessing the impact of HRQoL in patients with AL amyloidosis. The range and severity of symptoms of this disease, as well as the side effects of treatment, have been shown to greatly impact HRQoL [ 8 , 10 , 11 , 14 ], clearly warranting more standardized use of HRQoL measures that are capable of capturing the impacts of such diverse experiences.…”

Section: Discussionmentioning

confidence: 99%

“…The semi-structured interview guides that were used for each part of the study were informed by a thorough literature review of published reports of HRQoL in patients with AL amyloidosis [ 8 – 11 , 13 , 14 ]. Inclusion criteria were set so that all patients were at least 18 years of age, self-reported having been diagnosed with AL amyloidosis by a physician, and were able to complete the interview in English.…”

Section: Methodsmentioning

confidence: 99%

Content validation of the SF-36v2® health survey with AL amyloidosis patients

White

Bayliss

Guthrie

et al. 2017

J Patient Rep Outcomes

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BackgroundThis study examined the content validity of the SF-36v2® Health Survey (SF-36v2) in patients with AL amyloidosis using qualitative interviews with physicians and patients. The study included three distinct phases of qualitative research: concept elicitation interviews among physicians, concept elicitation interviews among patients, and cognitive debriefing interviews among patients. The concept elicitation interviews focused on areas of health-related quality of life that are affected by AL amyloidosis and may be affected by treatment, while patient cognitive debriefings aimed to confirm whether the SF-36v2 instructions, recall period, items, and response choices were comprehensive and understandable to AL amyloidosis patients.ResultsPhysicians discussed the importance of measuring physical functioning, general health, mental/emotional health, sleep, fatigue, and work impact; though they also reported that they do not routinely use a standard Patient-Reported Outcome (PRO) measure of health-related quality of life. Patients described social, physical, role, and emotional impacts of AL amyloidosis and various treatments. Cognitive debriefing interviews confirmed the relevance of the concepts measured by the SF-36v2 and indicated that patients found the SF-36v2 both easy to understand and complete, that the SF-36v2 instructions and items were comprehensive and understandable without change, and the response choices and recall period were appropriate for use with patients with AL amyloidosis.ConclusionsThe findings support the content validity of the SF-36v2 as an appropriate measure of health-related quality of life in patients with AL amyloidosis.

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Anxiety and depression among amyloid light-chain cardiac amyloidosis patients: The role of life satisfaction

Abstract: Overall, findings highlight the importance of subjective well-being (e.g. life satisfaction) to reduce anxious and depressive symptoms and to improve general health in AL patients.

Cited by 12 publications

References 21 publications

Influence of Life Satisfaction on Quality of Life: Mediating Roles of Depression and Anxiety Among Cardiovascular Disease Patients

Influence of Life Satisfaction on Quality of Life: Mediating Roles of Depression and Anxiety Among Cardiovascular Disease Patients

The burden of amyloid light chain amyloidosis on health-related quality of life

Content validation of the SF-36v2® health survey with AL amyloidosis patients

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