Anwendung mehrschichtig aufgenähter Amnionmembranen in der Erstbehandlung penetrierender Hornhautulzera

Müller, Michael; Meltendorf, Christian; Mirshahi, Alireza; Kohnen, T

doi:10.1055/s-0028-1109633

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…; Müller et al. ). Regarding corneal re‐epithelialization, success rates varied from 19% to 91% (Fereira de Souza et al.…”

Section: Discussionmentioning

confidence: 96%

“…Successful epithelialization of the corneal surface following the use of mostly glycerine-preserved mono-or multilayer human amniotic membranes has been observed in several clinical investigations. These membranes were applied in patients who suffered from various diseases of the ocular surface: corneal epithelial defects (Prabhasawat et al 2001;Letko et al 2001), ulcers (Kruse et al 1999;Chen et al 2000;Fereira de Souza et al 2001;Hanada et al 2001;Dogru et al 2003;Chen et al 2006;Nubile et al 2011;Iakimento et al 2013;Berguiga et al 2013) or perforation (Chen et al 2006;M€ uller et al 2009). Regarding corneal re-epithelialization, success rates varied from 19% to 91% (Fereira de Souza et al 2001;Nubile et al 2011;Berguiga et al 2013), and improved visual acuity was found in 18-90% of patients (Fereira de Souza et al 2001;Dogru et al 2003;Prabhasawat et al 2001).…”

Section: Discussionmentioning

confidence: 99%

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Long‐term efficacy of glycerine‐processed amniotic membrane transplantation in patients with corneal ulcer

Uhlig¹,

Frings²,

Rohloff³

et al. 2015

Acta Ophthalmologica

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ABSTRACT.Purpose: The aim of this study was to determine the long-term treatment efficacy of glycerine-preserved human amniotic membrane transplantation in patients suffering from corneal ulcers. Methods: This was a retrospective, non-controlled, monocentric analysis. Included were patients with corneal ulcers that were non-responsive to ointment or contact lenses and had been treated by amniotic membrane transplantation with either the overlay or sandwich procedure. Analysis parameters were visual acuity before and following treatment, recurrence rate and subjective comfort at the last follow-up. Results: Of the 371 amniotic membrane transplantations that were conducted, 135 surgical treatments in 108 patients (51.9% male, 48.1% female; mean age 63.7 years) met the inclusion criteria. In total, 99 overlay and 36 multilayer amniotic membrane transplantations were performed. The follow-up period was 47.5 AE 66.7 weeks (mean AE SD). The recurrence rate at the last follow-up was 47.8% with overlay membranes and 51.8% with the sandwich technique. There was no significant change in best-corrected visual acuity following treatment with overlays (p = 0.219) or sandwich procedure (p = 0.703). At the last follow-up, 72.1% (overlay) and 78.3% (sandwich) of the patients reported either no pain or increased comfort. Conclusion: The recurrence rates and changes in visual acuity following overlay or sandwich amniotic membrane transplantation in patients suffering from corneal ulcer were lower than reported elsewhere in the literature. More than half of the patients profited from each of the amniotic membrane transplantation techniques with respect to recurrence and postoperative comfort.

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“…; Müller et al. ). Regarding corneal re‐epithelialization, success rates varied from 19% to 91% (Fereira de Souza et al.…”

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Long‐term efficacy of glycerine‐processed amniotic membrane transplantation in patients with corneal ulcer

Uhlig¹,

Frings²,

Rohloff³

et al. 2015

Acta Ophthalmologica

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Amniotic membrane transplantation in cases of corneal calcification – follow up with ultrasound biomicroscopy

Sohár

Nógrádi

Kolozsvári

2011

Spektrum Augenheilkd.

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Matrix metalloproteinase 14 overexpression reduces corneal scarring

Fournié

Massoudi

et al. 2010

Gene Ther

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Once a corneal scar develops, surgical management remains the only option for visual rehabilitation. Corneal transplantation is the definitive treatment for a corneal scar. In addition to the challenges posed by graft rejections and other postoperative complications, the lack of high-quality donor corneas can limit the benefits possible with keratoplasty. The purpose of our study was to evaluate a new therapeutic strategy for treating corneal scarring by targeting collagen deposition. We overexpressed a fibril collagenase (matrix metalloproteinase 14 (MMP14)) to prevent collagen deposition in the scar tissue. We demonstrated that a single and simple direct injection of recombinant adeno-associated virus-based vector expressing murine MMP14 can modulate gene expression of murine stromal keratocytes. This tool opens new possibilities with regard to treatment. In a mouse model of corneal full-thickness incision, we observed that MMP14 overexpression reduced corneal opacity and expression of the major genes involved in corneal scarring, especially type III collagen and a-smooth muscle actin. These results represent proof of concept that gene transfer of MMP14 can reduce scar formation, which could have therapeutic applications after corneal trauma.

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Anwendung mehrschichtig aufgenähter Amnionmembranen in der Erstbehandlung penetrierender Hornhautulzera

Abstract: Our data show that an initial treatment of penetrating corneal ulcers with multilayer amniotic membrane is reasonable. With this procedure the surgeon gains sufficient time for obtain a corneal graft for a possible penetrating corneal transplantation.

Cited by 4 publications

References 9 publications

Long‐term efficacy of glycerine‐processed amniotic membrane transplantation in patients with corneal ulcer

Long‐term efficacy of glycerine‐processed amniotic membrane transplantation in patients with corneal ulcer

Amniotic membrane transplantation in cases of corneal calcification – follow up with ultrasound biomicroscopy

Matrix metalloproteinase 14 overexpression reduces corneal scarring

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