“…Reports have implicated the role of sodium hyaluronate artificial tears, preservatives of eyedrops with phosphate buffers, timolol, retinoic acid and dexamethasone in calcium salt depositions (36,41,42). Calcium salt deposition can also occur in cases of older patients, decreased tear production, and history with previous herpes virus infection (37,45). The high phosphate concentration leads to a critical increase of the calcium phosphate which together with the breakdown of the tissue barrier, results in the formation of hydroxyapatite deposits (36).…”