Antrummorphologie und Serumgastrinspiegel bei Achlorhydrie^*

Abstract

38 patients were found to have achlorhydria after maximal stimulation with pentagastrin and on multiple biopsies (atrophy of gastric mucosa). It was demonstrated that the sequence pH-antroreceptors-G cells-parietal cells-pH antroreceptors was interrupted already in mild or moderately severe superficial gastritis of the antral mucosa involving more than half of the antral surface. Reduction of specific functional epithelium is unlikely in this form of inflammation so that it is probably an effect of the pH receptors.

The Relation between Basal Gastric pH and Serum Gastrin

“…When an tral gastritis supervenes, the secretion of se rum gastrin is also affected by the disappear ance of G cells. The effect of this interaction will vary with the severity of the antral gastri tis [8],…”