Anton syndrome during oxygen-ozone therapy

Avcı, Sema; Büyükcam, Fatih; Demir, Ömer; Özkan, Seda

doi:10.1016/j.ajem.2014.11.041

Cited by 12 publications

(6 citation statements)

References 3 publications

(7 reference statements)

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“…In this study, ozone auto-hemotherapy was used to treat PHN, and an obvious clinical effect was achieved. The reasons for this clinical effect may be related to the following mechanisms: 1) Medical ozone has a strong bactericidal effect, and specific concentration of medical ozone can inhibit the growth and reproduction of herpes virus and promote the phagocytosis of leukocytes for herpes virus; 30 , 31 2) medical ozone can increase the oxygen-carrying ability and erythrocyte rheology of red blood cells, increase the oxygen supply for tissues and cells, improve the microcirculation in damaged nerve and skin tissue, and promote the repair of local nerves and tissue; 32 3) medical ozone mixed with blood can produce hydrogen peroxide (H 2 O 2 ), which can be as an important messenger, activate the body’s immune system, initiate a series of chemical reactions, induce the production of interleukin and interferon and other cytokines to activate and regulate the immune system function, and, finally, restore the normal functioning of the thalamus for the pain loop; 33 4) ozone autohemotherapy can bring a pleasant sensation to the person, relieve the patient’s fatigue and depression, and improve physical strength and mental stability. 34 In addition, reactive oxygen species (ROS) and lipid oxidative products (LOPs), believed to be involved in the biological progress of ozone, are produced immediately after ozone is dissolved in biological water (plasma, lymph, urine, interstitial fluid, etc.).…”

Section: Discussionmentioning

confidence: 99%

The effect and safety of ozone autohemotherapy combined with pharmacological therapy in postherpetic neuralgia

Hu¹,

Zheng²,

Liu³

et al. 2018

JPR

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IntroductionWe investigated the effect and safety of ozone autohemotherapy combined with pharmacological therapy in postherpetic neuralgia (PHN).MethodsNinety-eight patients with PHN were enrolled in this study and randomly divided into a pharmacological therapy group and ozone autohemotherapy group (49 patients in each group). The PHN patients in the pharmacological therapy group were administered pharmacological therapy for 2 weeks, whereas PHN patients in the ozone autohemotherapy group were given ozone autohemotherapy (200 mL blood from patients, the concentration of medical ozone was set as 30 μg/mL using an ozone medical apparatus, 40 mL medical ozone was incubated in 200 mL autologous blood for 3–5 minutes) combined with pharmacological therapy for 2 weeks. The Visual Analog Scale (VAS), the 50% VAS reduction in the initial value, McGill Pain Questionnaire (MPQ), the Patients’ Global Impression of Change (PGIC) scale, and the World Health Organization Quality of Life (WHOQOL-BREF) instrument were used to evaluate the outcomes of all PHN patients before therapy and at 1 week, 1 month, and 3 months after therapy.ResultsForty-five patients in the pharmacological therapy group and 47 patients in the ozone autohemotherapy group completed the study. Compared with before therapy, the two groups showed significant improvements in VAS, MPQ, PGIC, and WHOQOL-BREF scores after therapy (P<0.05). Moreover, compared with the scores of the pharmacological therapy group, the ozone autohemotherapy group’s scores were significantly improved in the VAS, MPQ, PGIC, and WHOQOL-BREF as well as the 50% VAS reduction of the initial value after therapy (P<0.05). Finally, there were no statistically significant differences in adverse effects between groups after therapy (P>0.05).ConclusionThe results of this study demonstrated that ozone autohemotherapy combined with pharmacological therapy was superior to isolated pharmacological therapy in patients with PHN and was an effective and safe way to relieve PHN.

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Section: Discussionmentioning

confidence: 99%

The effect and safety of ozone autohemotherapy combined with pharmacological therapy in postherpetic neuralgia

Hu¹,

Zheng²,

Liu³

et al. 2018

JPR

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“…To our knowledge, only four cases of vertebrobasilar stroke during OOT exists in literature[ 8 9 10 11 ] but only one refers to intradiscal therapy and none of them had cardiac abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Transient cortical blindness after intradiscal oxygen–ozone therapy

Vaiano

Valente

Benedetti

et al. 2016

Indian J Ophthalmol

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A 54-year-old caucasian male developed bilateral blindness during an oxygen–ozone injection for disc herniation. The visual loss (VL) was immediately followed by severe frontal headache, vomiting, and nausea. The patient underestimated the VL showing Anton's syndrome, with a complete visual recovery after 2-month follow-up. Magnetic resonance data were consistent with recent ischemic lesions in bilateral vascular territories of posterior cerebral arteries.

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“…However, it is not possible to make a proposal by evaluating the low quality scientific data. Furthermore, vertebrobasilar system stroke and sudden death after ozone therapy in the literature show possible complications and the seriousness of the condition (53,54,55).…”

Section: Ozone Therapymentioning

confidence: 99%