Antiviral therapy for adenovirus infections

Lenaerts, Liesbeth; Naesens, Lieve

doi:10.1016/j.antiviral.2006.04.007

Cited by 98 publications

(94 citation statements)

References 87 publications

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“…OBP-301-induced elevation of uric acid levels could be inhibited in the presence of cidofovir (CDV), an acyclic nucleoside phosphonate having potent broad-spectrum anti-DNA virus activity (Figure 2c). CDV has been approved for the treatment of many types of viruses including cytomegalovirus and adenovirus (Lenaerts and Naesens, 2006). We confirmed that CDV at 100 mM could significantly inhibited replication of OBP-301 in H1299 cells by the real-time quantitative PCR analysis (Supplementary Figure 2).…”

Section: Resultssupporting

confidence: 67%

Virus-mediated oncolysis induces danger signal and stimulates cytotoxic T-lymphocyte activity via proteasome activator upregulation

et al. 2007

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Dendritic cells (DCs) are the most potent antigenpresenting cells and acquire cellular antigens and danger signals from dying cells to initiate antitumor immune responses via direct cell-to-cell interaction and cytokine production. The optimal forms of tumor cell death for priming DCs for the release of danger signals are not fully understood. OBP-301 (Telomelysin) is a telomerasespecific replication-competent adenovirus that induces selective E1 expression and exclusively kills human cancer cells. Here, we show that OBP-301 replication produced the endogenous danger signaling molecule, uric acid, in infected human tumor cells, which in turn stimulated DCs to produce interferon-c (IFN-c) and interleukin 12 (IL-12). Subsequently, IFN-c release upregulated the endogenous expression of the proteasome activator PA28 in tumor cells and resulted in the induction of cytotoxic T-lymphocytes. Our data suggest that virus-mediated oncolysis might be the effective stimulus for immature DCs to induce specific activity against human cancer cells.

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Section: Resultssupporting

confidence: 67%

Virus-mediated oncolysis induces danger signal and stimulates cytotoxic T-lymphocyte activity via proteasome activator upregulation

et al. 2007

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“…35,36 Cidofovir is a monophosphate nucleotide analog of cytosine that is phosphorylated intracellularly to a diphosphate that can inhibit viral DNA polymerase and thus viral replication. 37 It was first approved by the Food and Drug Administration in 1996 for the treatment of CMV retinitis. The antiviral selectivity of the acyclic nucleotide/nucleoside phosphonates is based on their higher affinity for the viral DNA polymerase compared with cellular DNA polymerases.…”

Section: Antiviral Drugsmentioning

confidence: 99%

How I treat adenovirus in hematopoietic stem cell transplant recipients

Lindemans

Leen

Boelens

2010

Blood

211

215

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“…Similarly, most evidence for in vivo efficacy of antiviral therapy against adenovirus in the preemptive setting is also available for cidofovir [86,87]. Cidofovir is a nucleotide analog of cytosine that selectively inhibits viral DNA polymerase and subsequently viral replication by competitive incorporation of its active metabolite cidofovir diphosphate into viral DNA chain, disrupting synthesis and replication [88].…”

Section: Antiviral Agentsmentioning

confidence: 99%

The Repertoire of Adenovirus in Human Disease: The Innocuous to the Deadly

Khanal¹,

Ghimire²,

Dhamoon³

2018

Preprint

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Abstract:Adenovirus is a family of double stranded DNA viruses that are a significant cause of upper respiratory tract infections in children and adults. Less commonly, the adenovirus family can cause a variety of gastrointestinal, ophthalmologic, genitourinary, and neurologic diseases. Most adenovirus infections are self-limited in the immunocompetent host and are treated with supportive measures. Fatal infections can occur in immunocompromised patients and less frequently in the healthy. Adenoviral vectors are being studied for novel biomedical applications including gene therapy and immunization. In this review we will focus on the spectrum of adenoviral infections in humans.

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Antiviral therapy for adenovirus infections

Cited by 98 publications

References 87 publications

Virus-mediated oncolysis induces danger signal and stimulates cytotoxic T-lymphocyte activity via proteasome activator upregulation

Virus-mediated oncolysis induces danger signal and stimulates cytotoxic T-lymphocyte activity via proteasome activator upregulation

How I treat adenovirus in hematopoietic stem cell transplant recipients

The Repertoire of Adenovirus in Human Disease: The Innocuous to the Deadly

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