Antiviral Role of Phenolic Compounds against Dengue Virus: A Review

Loaiza-Cano, Vanessa; Monsalve-Escudero, Laura Milena; Filho, Carlos da Silva Maia Bezerra; Martínez-Gutiérrez, Marlen; Sousa, Damião Pergentino de

doi:10.3390/biom11010011

Cited by 43 publications

(28 citation statements)

References 206 publications

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“…Phorbol ester (PMA) is also an inhibitor of the TNF-α levels post-DENV infection [ 130 , 131 ]. Although there are many such phenolic compounds, such as, Fisetin, Naringin, Catechin, and Delphinidin, that showed inhibitory effects on the DENV in pre- and post-treatments, their mechanisms of inhibition have yet to be clarified [ 132 , 133 , 134 , 135 ]. Resveratrol, a phytoalexin antiviral to other Flaviviruses, was also shown to attack the DENV genome directly [ 136 ].…”

Section: Antivirals Against Dengue Infectionmentioning

confidence: 99%

“…Policresulen inhibits the NS2B/NS3 protease of the DENV to restrict viral replication in BHK-21 cells [ 140 ]. Honokiol is another potent inhibitor of the early DENV pathogenesis steps in BHK cells by the downregulation of the NS1 and NS3 proteins as well as the RNA intermediates of the DENV [ 135 , 141 ]. Diterpenes and derivatives from Curcuma longa and Basilicum polystachyon were also found to be effective against the DENV [ 142 , 143 ].…”

Section: Antivirals Against Dengue Infectionmentioning

confidence: 99%

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Dengue Virus Infection: A Tale of Viral Exploitations and Host Responses

Nanaware

Banerjee

Bagchi

et al. 2021

Viruses

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Dengue is a mosquito-borne viral disease (arboviral) caused by the Dengue virus. It is one of the prominent public health problems in tropical and subtropical regions with no effective vaccines. Every year around 400 million people get infected by the Dengue virus, with a mortality rate of about 20% among the patients with severe dengue. The Dengue virus belongs to the Flaviviridae family, and it is an enveloped virus with positive-sense single-stranded RNA as the genetic material. Studies of the infection cycle of this virus revealed potential host targets important for the virus replication cycle. Here in this review article, we will be discussing different stages of the Dengue virus infection cycle inside mammalian host cells and how host proteins are exploited by the virus in the course of infection as well as how the host counteracts the virus by eliciting different antiviral responses.

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Section: Antivirals Against Dengue Infectionmentioning

confidence: 99%

Section: Antivirals Against Dengue Infectionmentioning

confidence: 99%

Dengue Virus Infection: A Tale of Viral Exploitations and Host Responses

Nanaware

Banerjee

Bagchi

et al. 2021

Viruses

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“…Furthermore, they also play a relevant feature in the control of viral infections of Dengue virus [ 37 ], human immunodeficiency virus [ 38 ], severe fever with thrombocytopenia syndrome virus [ 39 ], hepatitis B virus and influenza virus [ 40 , 41 , 42 ], through inhibitory mechanisms of interaction, binding and replication of the virus in the host cells.…”

Section: Phenolic Compounds In Human Healthmentioning

confidence: 99%

Consumption of Phenolic-Rich Food and Dietary Supplements as a Key Tool in SARS-CoV-19 Infection

Flores-Félix

Gonçalves

Alves

et al. 2021

Foods

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The first cases of COVID-19, which is caused by the SARS-CoV-2, were reported in December 2019. The vertiginous worldwide expansion of SARS-CoV-2 caused the collapse of health systems in several countries due to the high severity of the COVID-19. In addition to the vaccines, the search for active compounds capable of preventing and/or fighting the infection has been the main direction of research. Since the beginning of this pandemic, some evidence has highlighted the importance of a phenolic-rich diet as a strategy to reduce the progression of this disease, including the severity of the symptoms. Some of these compounds (e.g., curcumin, gallic acid or quercetin) already showed capacity to limit the infection of viruses by inhibiting entry into the cell through its binding to protein Spike, regulating the expression of angiotensin-converting enzyme 2, disrupting the replication in cells by inhibition of viral proteases, and/or suppressing and modulating the host’s immune response. Therefore, this review intends to discuss the most recent findings on the potential of phenolics to prevent SARS-CoV-2.

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“…There are several studies had been conducted regarding potential bioactive compounds that may act as antiviral against DENV (Loaiza-Cano et al, 2021). The nonstructural protein, especially the NS2B/NS3 protease and NS5, are the most commonly used target proteins in the antiviral development process because they have well-mapped enzymatic activity for viral polyprotein and RNA synthesis (Norazharuddin & Shin, 2018;Jennings & Parks, 2020).…”

Section: Introductionmentioning

confidence: 99%

In Silico Targeting DENV2's Prefusion Envelope Protein by Several Natural Products' Bioactive Compounds

Hidayatullah

Putra

Sustiprijatno

et al. 2021

CMUJNS

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Dengue caused by the dengue virus (DENV) is a severe health problem in tropical regions such as Southeast Asia, especially Indonesia. Indonesian have used rhizome as traditional medicine for 1300 years. This study investigated the compounds from Kaempferia galanga, Curcuma longa, Zingiber officinale, Curcuma aeruginosa, Curcuma zanthorrhiza, Alpinia galanga, and Allium sativum as antivirals agents, explicitly targeting the DENV envelope protein to inhibit viral fusion. This study involved 121 bioactive compounds and DENV2's prefusion envelope protein. The virtual screening and molecular docking were done through occupied the Lipinski rule of five checker (http://www.scfbio-iitd.res.in/software/drugdesign/lipinski.jsp) and AutoDock Vina (https://pyrx.sourceforge.io/) respectively. The top nine compounds with the strongest binding affinity were galangin, kampferide, demetoxy curcumin, bisdemethoxycurcumin, β-selinene, 6-(hydroxymethyl)-1,4,4-trimethylbicyclo[3.1.0]hexan-2-ol, piperine, estra-1,3, 5(10)-trien-17β-ol, and curcumin. These compounds' affinity values were significantly lower, around 45-62%, than chloroquine. Most of them interact with the kl hairpin and hydrophobic pocket formed by residues Val130, Leu135, Phe193, Leu198, and Phe279of critical domains that can interfere with the conformational change and rearrangement of protein dimer in the post-fusion stage. This study suggested that the galangin, demethoxycurcumin, and bisdemethoxycurcumin are considered the most potential compounds to be developed as anti-prefusion E DENV2 low-affinity and intense interaction with those. Keywords: DENV2, envelope protein, in silico, viral fusion, viral infection

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Antiviral Role of Phenolic Compounds against Dengue Virus: A Review

Cited by 43 publications

References 206 publications

Dengue Virus Infection: A Tale of Viral Exploitations and Host Responses

Dengue Virus Infection: A Tale of Viral Exploitations and Host Responses

Consumption of Phenolic-Rich Food and Dietary Supplements as a Key Tool in SARS-CoV-19 Infection

In Silico Targeting DENV2's Prefusion Envelope Protein by Several Natural Products' Bioactive Compounds

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