Antiviral Potential of Exogenous Human Omega Interferon to Inhibit Pandemic 2009 A (H1N1) Influenza Virus

Xu, Chun’e; Song, Xiaohong; Fu, Ling; Dong, Dayong; Wu, Shipo; Li, Guanlin; Yi, Shaoqiong; Takata, Yasuyuki; Yu, Rui; Hou, Lihua; Chen, Wei

doi:10.1089/vim.2011.0003

Cited by 10 publications

(9 citation statements)

References 16 publications

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“…Human IFN-ω reduces levels of influenza viral load dose dependently in vivo , and daily intranasal treatment inhibits viral replication in lung tissues of guinea pigs [158]. The different antiviral effects of IFN-ω have been investigated with other IFNs.…”

Section: Influenza Virusmentioning

confidence: 99%

“…The different antiviral effects of IFN-ω have been investigated with other IFNs. IFN-β and IFN-ω show similar inhibitory activity against influenza virus at all IFN concentrations and both IFNs are significantly more potent at suppressing Ca/04 influenza virus infection than IFN-α at certain concentrations [158]. Another study suggested that IFN-ω activity was two times lower than IFN-β1a activity and somewhat lower than IFN-λ1 and IFN-λ2 activities [159].…”

Section: Influenza Virusmentioning

confidence: 99%

See 1 more Smart Citation

Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection

Gong

Zhao

et al. 2018

Cell Physiol Biochem

137

111

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The interferons (IFNs) are a primary defense against pathogens because of the strong antiviral activities they induce. IFNs can be classified into three groups: type I, type II and type III, according to their genetic, structural, and functional characteristics and their receptors on the cell surface. The type I IFNs are the largest group and include IFN-α, IFN-β, IFN-ε, IFN-ω, IFN-κ, IFN-δ, IFN-τ and IFN-ζ. The use of IFNs for the treatment of viral infectious diseases on their antiviral activity may become an important therapeutic option, for example, IFN-α is well known for the successful treatment of hepatitis B and C virus infections, and interest is increasing in the antiviral efficacy of other novel IFN classes and their potential applications. Therefore, in this review, we summarize the recent progress in the study of the biological activities of all the type I IFN classes and their potential applications in the treatment of infections with immunodeficiency virus, hepatitis viruses, and influenza viruses.

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Section: Influenza Virusmentioning

confidence: 99%

Section: Influenza Virusmentioning

confidence: 99%

Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection

Gong

Zhao

et al. 2018

Cell Physiol Biochem

137

111

View full text Add to dashboard Cite

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“…The virus load decreases markedly in response to antiviral treatment. 53,54 Studies on HBoV1 have consistently shown persistence or recurrence of HBoV1 DNA in the upper airways at low load long after infection. On the other hand, a high HBoV1 load is reportedly associated with acute HBoV infection and LRTI.…”

Section: Virus Loadmentioning

confidence: 99%

New molecular virus detection methods and their clinical value in lower respiratory tract infections in children

Jartti

Söderlund‐Venermo

Hedman

et al. 2013

Paediatric Respiratory Reviews

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During the past decade, several new respiratory viruses and their subgroups have been discovered. All these new viruses, as well as previously known respiratory viruses, can be detected by sensitive PCR methods, which have become popular in the diagnostic workup of respiratory viral infections. Currently, respiratory viruses can be detected in up to 95% of children with lower respiratory tract illness. On the other hand, virus detection rates in asymptomatic children are also high (up to 68%), as are coinfection rates in symptomatic children (up to 43%) and justified concerns of causality have been raised. Imposing progress has been made in developing multiplex quantitative PCR assays; here, several primer sets are run within a single PCR mixture. These PCR assays give a better understanding of the dominant viral infection, of viral infections that may be incipient and of any waning infections than does a single-target PCR. Multiplex PCR assays are also gaining popularity due to their cost-effectiveness and short throughput time compared to multiple single-target PCRs. Our understanding of the indications of virus PCRs and our ability to interpret the results from a clinical point of view have improved. This paper reviews the progress in PCR assays and discusses their role in the diagnosis of lower respiratory tract infections in children.

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“…The influenza A H1N1 virus A/Beijing/501/2009 (BJ501) was isolated from a patient from Beijing in 2009 [5], [12], [13]. The genomic sequences are available in GenBank under the accession numbers GQ223408-GQ223415.…”

Section: Methodsmentioning

confidence: 99%

Characterization of the 2009 Pandemic A/Beijing/501/2009 H1N1 Influenza Strain in Human Airway Epithelial Cells and Ferrets

Yang

Deng

et al. 2012

PLoS ONE

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BackgroundA novel 2009 swine-origin influenza A H1N1 virus (S-OIV H1N1) has been transmitted among humans worldwide. However, the pathogenesis of this virus in human airway epithelial cells and mammals is not well understood.Methodology/Principal FindingIn this study, we showed that a 2009 A (H1N1) influenza virus strain, A/Beijing/501/2009, isolated from a human patient, caused typical influenza-like symptoms including weight loss, fluctuations in body temperature, and pulmonary pathological changes in ferrets. We demonstrated that the human lung adenocarcinoma epithelial cell line A549 was susceptible to infection and that the infected cells underwent apoptosis at 24 h post-infection. In contrast to the seasonal H1N1 influenza virus, the 2009 A (H1N1) influenza virus strain A/Beijing/501/2009 induced more cell death involving caspase-3-dependent apoptosis in A549 cells. Additionally, ferrets infected with the A/Beijing/501/2009 H1N1 virus strain exhibited increased body temperature, greater weight loss, and higher viral titers in the lungs. Therefore, the A/Beijing/501/2009 H1N1 isolate successfully infected the lungs of ferrets and caused more pathological lesions than the seasonal influenza virus. Our findings demonstrate that the difference in virulence of the 2009 pandemic H1N1 influenza virus and the seasonal H1N1 influenza virus in vitro and in vivo may have been mediated by different mechanisms.Conclusion/SignificanceOur understanding of the pathogenesis of the 2009 A (H1N1) influenza virus infection in both humans and animals is broadened by our findings that apoptotic cell death is involved in the cytopathic effect observed in vitro and that the pathological alterations in the lungs of S-OIV H1N1-infected ferrets are much more severe.

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Antiviral Potential of Exogenous Human Omega Interferon to Inhibit Pandemic 2009 A (H1N1) Influenza Virus

Cited by 10 publications

References 16 publications

Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection

Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection

New molecular virus detection methods and their clinical value in lower respiratory tract infections in children

Characterization of the 2009 Pandemic A/Beijing/501/2009 H1N1 Influenza Strain in Human Airway Epithelial Cells and Ferrets

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