Antiviral peptides against Enterovirus A71 causing hand, foot and mouth disease

Lalani, Salima; Gew, Lai Ti; Poh, Chit Laa

doi:10.1016/j.peptides.2020.170443

Cited by 15 publications

(4 citation statements)

References 68 publications

(83 reference statements)

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“…Additionally, antiviral peptides possess broad-spectrum activity with minimum side effects ( Heydari et al, 2021 ). Several antiviral peptides have been previously reported, including anti-neurovirulent enterovirus A71 peptide SP40 ( Lalani, Gew, & Poh, 2021 ), anti-influenza virus peptide M2 AH ( Jung et al, 2019 ), and anti-Japanese encephalitis virus peptide P1 ( Yu et al, 2021 ). Antiviral peptides that exhibit anti-coronavirus activity have also been reported, such as antiviral peptides (AVPs) reported by ( Hollmann, Cardoso, Espeche, & Maffía, 2021 ) and antiviral peptide P9R ( Zhao et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Identification of lactoferrin-derived peptides as potential inhibitors against the main protease of SARS-CoV-2

Zhao

et al. 2022

LWT

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COVID-19 is a global health emergency that causes serious concerns. A global effort is underway to identify drugs for the treatment of COVID-19. One possible solution to the present problem is to develop drugs that can inhibit SARS-CoV-2 main protease (M pro ), a coronavirus protein that been considered as one among many drug targets. In this work, lactoferrin from Bos taurus L. was in silico hydrolyzed. The bioactivity, water solubility, and ADMET properties of the generated peptides were predicted using various online tools. The molecular interactions between M pro and the peptides were studied using molecular docking and molecular dynamic simulation. The results demonstrated that peptide GSRY was predicted to have better physicochemical properties, and the value of ‘-C DOCKER interaction energy’ between peptide GSRY and M pro was 80.8505 kcal/mol. The interaction between the peptide GSRY and the native ligand N3 co-crystallized with M pro had overlapped amino acids, i.e., HIS163, GlY143, GLU166, GLN189 and MET165. Molecular dynamic simulation revealed that M pro /GSRY complexes were stable. Collectively, the peptide GSRY may be a potential candidate drug against M pro of SARS-CoV-2.

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Section: Introductionmentioning

confidence: 99%

Identification of lactoferrin-derived peptides as potential inhibitors against the main protease of SARS-CoV-2

Zhao

et al. 2022

LWT

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“…To overcome the immediate threat posed by constantly evolving pathogens and prevent future epidemics ( 3 ), broad-spectrum antimicrobial agents and novel drugs against drug-resistant strains are urgently needed ( 4 ). Antimicrobial peptides (AMPs) are amphiphilic peptides that selectively target and eliminate various microbial pathogens at low micromolar concentrations ( 5 , 6 ), with little or no induction of drug resistance ( 7 ) ( 8 ). AMPs are classified into synthetic peptides and natural antibiotics.…”

Section: Introductionmentioning

confidence: 99%

Bomidin: An Optimized Antimicrobial Peptide With Broad Antiviral Activity Against Enveloped Viruses

Liu

Peng

et al. 2022

Front. Immunol.

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The rapid evolution of highly infectious pathogens is a major threat to global public health. In the front line of defense against bacteria, fungi, and viruses, antimicrobial peptides (AMPs) are naturally produced by all living organisms and offer new possibilities for next-generation antibiotic development. However, the low yields and difficulties in the extraction and purification of AMPs have hindered their industry and scientific research applications. To overcome these barriers, we enabled high expression of bomidin, a commercial recombinant AMP based upon bovine myeloid antimicrobial peptide-27. This novel AMP, which can be expressed in Escherichia coli by adding methionine to the bomidin sequence, can be produced in bulk and is more biologically active than chemically synthesized AMPs. We verified the function of bomidin against a variety of bacteria and enveloped viruses, including severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), herpes simplex virus (HSV), dengue virus (DENV), and chikungunya virus (CHIKV). Furthermore, based on the molecular modeling of bomidin and membrane lipids, we elucidated the possible mechanism by which bomidin disrupts bacterial and viral membranes. Thus, we obtained a novel AMP with an optimized, efficient heterologous expression system for potential therapeutic application against a wide range of life-threatening pathogens.

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“…[8] However, there remains no vaccine or antiviral therapy for HFMD caused by EV71 that has been approved by the US FDA. [9] There is thus a need to create more effective preventive measures and treatments to reduce future causalities. [10] Marine biological resources have been identified as an excellent source of intriguing natural products with Supporting information for this article is available on the WWW under https://doi.org/10.1002/cbdv.202200475 Part of a Special Collection on Marine Bioactives.…”

Section: Introductionmentioning

confidence: 99%

“…In 2010, the largest outbreak of HFMD associated with EV71 occurred in China, which included over 1.7 million cases, with 27.000 patients got serious nerve injuries and 905 deaths [8] . However, there remains no vaccine or antiviral therapy for HFMD caused by EV71 that has been approved by the US FDA [9] . There is thus a need to create more effective preventive measures and treatments to reduce future causalities [10] …”

Section: Introductionmentioning

confidence: 99%

Guignardones Y–Z, Antiviral Meroterpenes from Penicillium sp. NBUF154 Associated with a Crella Sponge from the Marine Mesophotic Zone

Zou

Ding

et al. 2022

Chemistry & Biodiversity

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Guignardones Y-Z (1 -2), two new meroterpenoids, and six known metabolites involving guignardones A -H (3 -4), gyorgy-isoflavone (5), daidzein (6), blumenol A (7) and guignardianone A (8) were isolated from the fungus Penicillium sp. NBUF154, which was obtained from a 60 m deep Crella sponge. Their structures including absolute configurations were unambiguously elucidated by exhaustive spectroscopic analysis and ECD calculations. A putative biosynthetic pathway toward guignardones (1 -4) is here proposed. Biological evaluation of compounds 1-8 showed that 1 and 7 exert potent inhibitory effects towards human enterovirus 71 (EV71).

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Antiviral peptides against Enterovirus A71 causing hand, foot and mouth disease

Abstract: Graphical abstract

Cited by 15 publications

References 68 publications

Identification of lactoferrin-derived peptides as potential inhibitors against the main protease of SARS-CoV-2

Identification of lactoferrin-derived peptides as potential inhibitors against the main protease of SARS-CoV-2

Bomidin: An Optimized Antimicrobial Peptide With Broad Antiviral Activity Against Enveloped Viruses

Guignardones Y–Z, Antiviral Meroterpenes from Penicillium sp. NBUF154 Associated with a Crella Sponge from the Marine Mesophotic Zone

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