Antiviral lanostanoid triterpenes from the fungus Ganoderma pfeifferi

Mothana, Ramzi A.; Ali, Nasser A. Awadh; Jansen, Rolf; Wegner, Ursula; Mentel, Renate; Lindequist, Ulrike

doi:10.1016/s0367-326x(02)00305-2

Cited by 104 publications

(66 citation statements)

References 9 publications

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“…Apart from Agaricus blazei, compounds from the basidiomycetes Ganoderma pfeifferi and Rozites caperata demonstrated antiviral activity for many viruses, such as herpes simplex (11,15). In this study, we evaluated the action of aqueous extract of A. blazei in the replication of HSV-1 and BoHV-1, in HEp-2 cell culture.…”

Section: Introductionmentioning

confidence: 99%

Antiviral activity of Agaricus blazei Murrill ss. Heinem extract against human and bovine herpesviruses in cell culture

Bruggemann¹,

Orlandi²,

Benati³

et al. 2006

Braz. J. Microbiol.

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The aqueous extract of Agaricus blazei Murill ss. Heinem, a basidiomycete native from Brazil, frequently used by popular medicine, mainly in the form of tea, was assessed to its antiviral action against herpes simplex type 1 (HSV-1) and bovine herpes type 1 (BoHV-1) in HEp-2 cell culture. Viral replication inhibition was evaluated by plaque assay and immunofluorescence test. The extract demonstrated virucide action for both viruses, being more effective against HSV-1, inhibiting its infectivity in 78.4 and 73.9% at the concentrations of 50 and 100 µg/mL, respectively moreover, reduction in 47% the number of fluorescent cells was observed for both concentrations. The extract also showed discrete therapeutic activity. These results suggest that A. blazei extract acts mainly in the viral particle, however, the effect during virus replication can not be ruled out.

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Section: Introductionmentioning

confidence: 99%

Antiviral activity of Agaricus blazei Murrill ss. Heinem extract against human and bovine herpesviruses in cell culture

Bruggemann¹,

Orlandi²,

Benati³

et al. 2006

Braz. J. Microbiol.

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“…Ganoderma pfeifferi triterpenes, ganodermadiol ( 20 ), lucidadiol ( 30 ) and applanoxidic acid G ( 4 ), were active against influenza virus type A with ED 50 of greater than 0.22 mM, 0.22 mM and 0.19 mM, respectively (MothanaRa et al 2003). Similarly others triterpenes such as ganoderone C ( 26 ) (IC 50 : 2.6 µ g/ml), lucialdehyde B ( 31 ) (IC 50 :3.0 µ g/ml) and ergosta-7, 22-dien-3 α -ol ( 14 ) (IC 50 : 0.78 µ g/ml) inhibited the growth of Madin-Darby canine kidney (MDCK) cells infected with influenza virus (Niedermeyer et al 2005).…”

Section: Antiviral Activities Of Compounds and Extracts From Ganodermmentioning

confidence: 99%

“…Similarly others triterpenes such as ganoderone C ( 26 ) (IC 50 : 2.6 µ g/ml), lucialdehyde B ( 31 ) (IC 50 :3.0 µ g/ml) and ergosta-7, 22-dien-3 α -ol ( 14 ) (IC 50 : 0.78 µ g/ml) inhibited the growth of Madin-Darby canine kidney (MDCK) cells infected with influenza virus (Niedermeyer et al 2005). Herpes simplex virus were inhibited by triterpenes such as compound ( 20 ) (ED 50 : 0.068 mM), ganoderone A ( 25 ) (IC 50 :0.075 µ g/ml), ( 31 ) (IC 50 :0.03 µ g/ml) and compound 14 (IC 50 : 0.03 µ g/ml), whereas compounds 21 and 51 were less effective in comparison (MothanaRa et al 2003; Niedermeyer et al 2005). G. lucidium triterpenes lanosta-7, 9 (11), 24-trien-3-one, 15; 26-dihydroxy (GLTA) ( 40 ) and ganoderic acid Y ( 19 ) possess inhibitory action towards enterovirus 71 with IC 50 value of 0.16–4 μ g/ml (Zhang et al 2015).…”

Section: Antiviral Activities Of Compounds and Extracts From Ganodermmentioning

confidence: 99%

Current and future perspective on antimicrobial and anti-parasitic activities of Ganoderma sp.: an update

Basnet

Liu

et al. 2017

Mycology

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Medicinal mushroom Ganoderma sp. is considered to be a key source for the production of therapeutic agents. Our current review indicates that a limited number (<19%; 79 out of >430) of isolated compounds have been tested and known to be active against several microorganisms and parasites. In this review, we aim to summarise all the antimicrobial and anti-parasitic works on Ganoderma sp. displayed on web of science, google scholar and endnote X7 from 1932 to August 2016. We further present and discuss the structure of active compounds against microorganisms and parasites. In addition, we also discuss the possible further research to identify lead compounds from Ganoderma sp. as a novel strategy to combat the potential global emergence of bad bugs and parasites.

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“…4), Applanoxidic acid C, 5,, Ergosterol peroxide (5,6,8(14), 22-tetraen-3-one, Lucialdehyde B, Lucialdehyde D, Ganoderol A, Ganoderol B (Fig. 4), Ganoderone A and Ganoderone C. Niedermeyer et al 2005 Ganomycins A and B Mothana et al 2000 Ganodermadiol, Lucidadiol, and Applanoxidic acid G Mothana et al 2003 Lucialdehyde D, Ganoderone A, and Ganoderone C. Ganoderone A and Lucialdehyde B, (and ergosta-7,22-dien-3b- Sixteen compounds were isolated by 2, 5-dihydroxyacetophenone, methyl gentisate, (S)-dimethyl malate, muurola-4, 10 (14)-dien-11β-ol, dihydroepicub-enol, 5-hydroxymethylfuran carboxaldehyde, ergosta-7, 22E-dien-3β-ol, ergosta-7, 22E-dien-3-one, ergosta-7, 22E-diene-2β, 3α, 9α-triol, 6β-methoxyergo-sta-7, 22E-dien-3β, 5α-diol, ergosta-4, 6, 8(14), 22E-tetraen-3-one, ergosta4, 6, 8-(14), 22E-etetraen-3β-ol, 5α, 8α-epidioxy-ergosta-6, 22E-dien-3β-ol, 7α-methoxy-5α, 6α-epoxyergosta-8-(14), 22E-dien-3β-ol (14), ergosta-8, 22E-diene-3β, 5α, 6β, 7α-tetraol, and ergosta-5, 23-dien-3β-ol, acetate.…”

Section: G Concinnum Ryvarden 2000mentioning

confidence: 99%

Mycosphere Essays 20: Therapeutic potential of Ganoderma species: Insights into its use as traditional medicine

Hapuarachchi¹

2017

Mycosphere

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The genus Ganoderma (Ganodermataceae) has a long history in traditional medicine to improve longevity and health in Asia. Ganoderma has been widely used in multiple therapeutic activities as well as dietary supplements to prevent and treat many diseases. Several classes of bioactive substances have been isolated and identified from Ganoderma, such as polysaccharides, triterpenoids, nucleosides, sterols, fatty acids, protein and alkaloids. There are numerous research publications, which report the abundance and variety of biological actions initiated by the metabolites of Ganoderma. Investigation on different metabolic activities of Ganoderma species has been performed both in vitro and in vivo. In many cases, however, it has been questioned whether Ganoderma is solely a nourishment supplement for wellbeing or merely a helpful "medication" for restorative purposes. There has been no any conclusive report of human trials using Ganoderma species as a direct control agent for diseases. In addition, there is no evidence supporting the usage of Ganoderma species (excluding G. lucidum) as potential supplements for cancer or other diseases in humans since no preclinical trials have been performed up to date. In this review, the beneficial medicinal properties of several species of Ganoderma (excluding G. lucidum) and their secondary metabolites are discussed. Ganoderma species can be used as a therapeutic drug, but more direct scientific evidence should be made available in the future. The efficiency of Ganoderma in clinical treatments should be substantiated with more biomedical research and their true impact assessed on human health with more standardized clinical evaluations so that the feasibility of biologically active extracts of Ganoderma species in alternative treatments can be recommended.

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Antiviral lanostanoid triterpenes from the fungus Ganoderma pfeifferi

Cited by 104 publications

References 9 publications

Antiviral activity of Agaricus blazei Murrill ss. Heinem extract against human and bovine herpesviruses in cell culture

Antiviral activity of Agaricus blazei Murrill ss. Heinem extract against human and bovine herpesviruses in cell culture

Current and future perspective on antimicrobial and anti-parasitic activities of Ganoderma sp.: an update

Mycosphere Essays 20: Therapeutic potential of Ganoderma species: Insights into its use as traditional medicine

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