Antiviral Effects of a Synthetic Aluminium-Magnesium Silicate on Avian Influenza Virus

Abstract

Effects of a synthetic Aluminium-Magnesium Silicate [AMS] on Avian Influenza Virus (AIV) were tested. Equal amounts of H 5 N 1 AIV samples and of AMS were mixed, left one hour, at room teperature before centrifuging. The supernatants were remeasured and tested for viral titre, for Mean Death Time (MDT) and Embryo Mortality Rate (EMR) of chicken eggs. Volumes of the viral samples reduced at rate of 23.4 ± 5.48 %. Viral titres reduced significantly (P from HA, 73 ± 32.72 to 1.4 ±0.43. Also, mortality of infected embryos reduced from 100 % to 65% while MDT of those that died,increased significantly (P = 0.001) from 76 ± 4.38 to 130 ±17.27 hours .When incubation with AMS was repeated on portions of same sample ,MDT increased from 64 to 104 hours with the portion incubated once .Two AIV portions on which incubation with AMS was repeated could not kill chick embryos. Background. Avian Influenza Viruses are enveloped, single stranded RNA viruses.Two different protein projections cover their envelopes. These are the Haemagglutinin (H) and the Nueraminidase (N) antigens. Combinations of the H and the N antigens is an important property of Influenza viruses because, it allows for resortment when two Influenza viruses replicate in same cell at the same time. Influenza viruses are classified into types, A, B and C, based on antigenic differences of their neuclocapsid and of their matrix proteins 1 .Avian Influenza Viruses are Influenza A viruses 2 .

HIV-Infection Reduction-Rates in Patients, on Antiretroviral Efficacy-Trial of a Nigerian Broad-Spectrum Antiviral Medicine (Antivirt<sup>®</sup>)

“…HIV titers of five other samples, also increased (P = 0.009) from a mean of 4.00 ± 1.63 to 14.00 ± 2.00 when treated with the Antivirt ® once. When treatment with the Antivirt ® was repeated, mean of the plasma-HIV titers reduced significantly (P = 0.024) from 14.00 ± 2.00 to 6.50 ± 1.50 [14]. The initial increase in viral loads and subsequent reductions reported by NIMR in this clinical trial is exact repeat of results of that in vitro study.…”

Site‐specific delivery of green tea coated aluminium magnesium silicate beads and studies on their effect against chicken coccidiosis

“…The AMS showed a highly negative charge due to the silicate molecules and it easily binds to amine group of the drug molecules and it facilitates the prolonged release of the drug. Recently, Ezeibe et al ., [13] reported that the AMS is highly effective against Fowl Pox Virus, New Castle Disease virus [14], Avian Influenza virus [15], Parvovirus [16], Infectious Bursal disease virus [17] and Antiplasmodial effects. In this study, the oral beads were developed to treat the chicken coccidiosis infection using green tea/AMS hybrid material.…”

Humoral Immune Response in Parvoviral Vaccinated Dogs Experimentally Infected with Trypanosoma congolense and Trypanosoma brucei

“…Canine parvovirus (CPV) is widely distributed in the global canine population and remains an important cause of morbidity and mortality in this species [4,5]. There are two common clinical forms: gastro-enteritis form common in adults and myocarditis form common in puppies [6]. The disease is characterized by lethargy, leucopenia, dehydration, anorexia, fever, vomiting and diarrhoea, which may contain mucus or blood with a very strong foul smell [7,2,8].…”