Antiviral Chromones from the Stem of Cassia siamea

Abstract

Seven new chromones, siamchromones A-G (1-7), and 12 known chromones (8-19) were isolated from the stems of Cassia siamea. Compounds 1-19 were evaluated for their antitobacco mosaic virus (anti-TMV) and anti-HIV-1 activities. Compound 6 showed antitobacco mosaic virus (anti-TMV) activity with an inhibition rate of 35.3% and IC50 value of 31.2 μM, which is higher than that of the positive control, ningnamycin. Compounds 1, 10, 13, and 16 showed anti-TMV activities with inhibition rates above 10%. Compounds 4, 6, 13, and 19 showed anti-HIV-1 activities with therapeutic index values above 50.

Butyrolactones derivatives from the fermentation products of a plant entophytic fungusPenicillium oxalicum

“…The 1 H and 13 C NMR spectra of 2 were similar to those of 1 at C-1ZC-6, C-1 0 ZC-6 0 and C-1 00 ZC-6 00 . The major difference resulted from the replacement of the prenyl group in 1 by a 2-oxopropyl group, -CH 2 C(O)CH 3 (Hu et al 2012) [d C 48.6 t, 206.8 s and 28.9 q; d H 4.30 (2H, s) and 2.31 (3H, s)] in 2. The HMBC correlations of H-7 00 (d H 4.30) with C-4 00 (d C 144.7), C-5 00 (d C 128.3) and C-6 00 (d C 124.8), and of H-6 00 (d H 6.92) with C-7 00 (d C 48.6) indicated that the 2-oxopropyl group was attached to C-5 00 .…”

ChemInform Abstract: Flavones from the Bark of Lindera caudata and Their anti‐Tobacco Mosaic Virus Activity

“…Since certain flavonoids exhibit potential anti‐TMV activity, compounds 1–8 were tested for their anti‐TMV activity. The anti‐TMV activity was tested using the half‐leaf method . Ningnanmycin (a commercial product for plant disease in China) was used as a positive control.…”

A New Phenolic Compound from the Stems of Flue-Cured Tobacco and Its Anti-Tobacco Mosaic Virus Activity

“…The long-range correlation of the methoxy proton signal (δ H 3.81) with C-2 (δ C 155.4) clearly indicated that the methoxy group located at C-2. The HMBC correlations of H-1' (δ H 3.58) Since certain of the phenolic compounds exhibit potential anti-TMV activity [19][20][21] , compounds 1 was tested for it anti-tobacco mosaic virus activity. The anti-TMV activities were tested using the half-leaf method 21 .…”

“…The HMBC correlations of H-1' (δ H 3.58) Since certain of the phenolic compounds exhibit potential anti-TMV activity [19][20][21] , compounds 1 was tested for it anti-tobacco mosaic virus activity. The anti-TMV activities were tested using the half-leaf method 21 . Ningnanmycin (2 % water solution), a commercial product for plant disease in China, was used as a positive control.…”