Antiviral and Cytotoxic Isocoumarin Derivatives from an Endophytic Fungus Aspergillus oryzae

Zhou, Min; Zhou, Kun; He, Ping; Wang, Kun-Miao; Zhu, Ruizhi; Wang, Yue-De; Dong, Wei; Li, Gan‐Peng; Yang, Haiying; Ye, Yanqing; Du, Gang; Li, Xuemei; Hu, Qiu‐Fen

doi:10.1055/s-0035-1558331

Cited by 53 publications

(15 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…20 µM. The results revealed that 111 and 112 had moderate anti-TMV potential (inhibition rates 28.4 and 30.6%, respectively) [94]. Antifeedant activities of 134 and 135 were evaluated against larvae of Spodoptera littoralis using glass-fiber discs.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

et al. 2020

View full text Add to dashboard Cite

Recently, the metabolites separated from endophytes have attracted significant attention, as many of them have a unique structure and appealing pharmacological and biological potentials. Isocoumarins represent one of the most interesting classes of metabolites, which are coumarins isomers with a reversed lactone moiety. They are produced by plants, microbes, marine organisms, bacteria, insects, liverworts, and fungi and possessed a wide array of bioactivities. This review gives an overview of isocoumarins derivatives from endophytic fungi and their source, isolation, structural characterization, biosynthesis, and bioactivities, concentrating on the period from 2000 to 2019. Overall, 307 metabolites and more than 120 references are conferred. This is the first review on these multi-facetted metabolites from endophytic fungi.

show abstract

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Oryzaeins A ( 156 ) and B ( 157 ) were isolated among metabolites from Aspergillus oryzae, and represented the first example of isocoumarins with an unusual 2-oxopropyl group and a rare 3-hydroxypropyl group. Both compounds displayed moderate antitobacco mosaic viral activities [ 92 ]. Among compounds isolated from Penicillium commune , peniisocoumarin A ( 158 ) and B ( 159 ) are unusual dimeric isocoumarins with a symmetric four-membered core at C-9/9′ and C-10/10′.…”

Section: Resultsmentioning

confidence: 99%

Structurally Uncommon Secondary Metabolites Derived from Endophytic Fungi

Ortega

Torres-Mendoza

et al. 2021

JoF

View full text Add to dashboard Cite

Among microorganisms, endophytic fungi are the least studied, but they have attracted attention due to their high biological diversity and ability to produce novel and bioactive secondary metabolites to protect their host plant against biotic and abiotic stress. These compounds belong to different structural classes, such as alkaloids, peptides, terpenoids, polyketides, and steroids, which could present significant biological activities that are useful for pharmacological or medical applications. Recent reviews on endophytic fungi have mainly focused on the production of novel bioactive compounds. Here, we focus on compounds produced by endophytic fungi, reported with uncommon bioactive structures, establishing the neighbor net and diversity of endophytic fungi. The review includes compounds published from January 2015 to December 2020 that were catalogued as unprecedented, rare, uncommon, or possessing novel structural skeletons from more than 39 different genera, with Aspergillus and Penicillium being the most mentioned. They were reported as displaying cytotoxic, antitumor, antimicrobial, antiviral, or anti-inflammatory activity. The solid culture, using rice as a carbon source, was the most common medium utilized in the fermentation process when this type of compound was isolated.

show abstract

“…The experimental response of these process variables was the production of glucose oxidase (U/ml). Prevalent in other environments such as water (Sessegolo et al, 2011;Oliveira et al, 2016), plants (Pinheiro et al, 2013;Zhou et al, 2016;Corrêa et al, 2014;Russell et al, 2011;Orlandelli et al, 2012), marine organisms (Debbab et al, 2012;Subramani et al, 2013;Hayashi et al, 2016;Cicatiello et al, 2016) and even the glacial arctic environment (Sonjak et al, 2006;Sonjak et al, 2007;Zhang et al, 2016). A fraction of the fungal isolates (20%) were able to produce GOx.…”

Section: Discussionmentioning

confidence: 99%

Aspergillus niger LMM01: A new source of glucose oxidase in Amazon

Sousa¹,

Santos²,

Cortez³

et al. 2017

Afr. J. Microbiol. Res.

View full text Add to dashboard Cite

Glucose oxidase (GOx) has several industrial applications. It is believed that there are several species of fungi that have the ability to produce this enzyme, most of which are unexplored. This work aimed to investigate the production of glucose oxidase (EC 1.1.3.4) by fungi isolated from soil samples of the Amazonian forest. Filamentous fungi were isolated from soil samples from the Adolpho Ducke Forest Reserve, located in Manaus, Amazonas. Strains were subjected to submerged bioprocessing to select for the best GOx producers. Those selected for the production of isolated enzymes were subjected to kinetic tests that evaluated production of the enzyme and consumption of the biomass substrate by the isolates. In addition, experiments to evaluate the optimal carbon, nitrogen and phosphorus sources as well as the influence of the bioprocess factors were carried out. Finally, GOx production was investigated in a semi-continuous system for 7 days. The most frequent isolates isolated from soil samples belonged to the genera Aspergillus, Penicillium and Trichoderma. Aspergillus niger LMM01 was the best GOx producer. Glucose, peptone and KH 2 PO 4 were demonstrated to be the optimal carbon, nitrogen and phosphorus sources, respectively. Multivariate experiments demonstrated that the parameters with the greatest effect on GOx production were pH and agitation. Stable expression results for GOx (7.74 U/ml) were obtained over 7 days in a semi-continuous process. In this context, the new Amazonian source of this enzyme (A. niger LMM01), and enzyme production in a semi-continuous process, demonstrates the importance of the present work.

show abstract

Antiviral and Cytotoxic Isocoumarin Derivatives from an Endophytic Fungus Aspergillus oryzae

Cited by 53 publications

References 10 publications

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

Naturally Occurring Isocoumarins Derivatives from Endophytic Fungi: Sources, Isolation, Structural Characterization, Biosynthesis, and Biological Activities

Structurally Uncommon Secondary Metabolites Derived from Endophytic Fungi

Aspergillus niger LMM01: A new source of glucose oxidase in Amazon

Contact Info

Product

Resources

About