Antiviral Activity of Water Extract of Sanicula europaea L. Leaves on the Bacteria-Bacteriophage System

Saniculoside N from Sanicula europaea L.

“…The extract was separated chromatographically by two different methods. Method 1 yielded the pure saponin glycoside (1) whereas method 2 afforded the phenolic acids, rosmarinic acid (2) and caffeic acid (3).…”

“…Sanicula europaea L. (Apiaceae) has been used as a traditional medicinal plant in the treatment of wounds, dermatological, gastrointestinal, upper airway, and urinary system diseases, and chronic chest pains , and in vitro virucidal effects in the phage−bacteria system, and antiinfluenza activity against influenza A. It was established that saponins are responsible for antimicrobial, hemolytic, and antioxidant activities, whereas hydroxycinnamic derivatives, especially rosmarinic acid, were responsible for antioxidant activity. , It was also reported that the presence of allantoin raised the value of the folk medicinal use of the plant …”

“…The CI mass spectrum of the aglycon gave a molecular ion peak at m/z 589. 3 13 unsaturation in the molecule. All of the spectral data of the new saponin and its aglycon revealed differences from those of the saponins reported formerly.…”

“…J ) 7 Hz, H-4′), 3.22 (dd, J ) 6.0, 6.0 Hz, H-3),3.31 (d, J ) 12 Hz, H-28′), 3.54 (d, J ) 12 Hz, H-28), 3.92 (d, J ) 10 Hz, H-22), 4.04 (bd, J ) 4 Hz, H-16), 4.31 (bs, H-15), 5.37 (bs, H-12), 5.40 (d, J ) 10…”