Antiviral activity of trifuzol for the broiler at poultry farm

Pruglo, Ye. S.; Pohorlyuk, A. Yu.; Парченко, В. В.; Панасенко, О. І.; Knysh, E. G.

doi:10.14739/2310-1210.2016.1.64062

Cited by 3 publications

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“…№РП АВ-05486-01-14) [23][24][25]. Scientists proved efficiency of 1% injectable solution in a pig at a dose of 1 ml per 10 kg of animal [23] and the 1% solution for oral use in poultry at a rate of one liter of 1% solution per a ton of water [24].…”

Section: Introductionmentioning

confidence: 99%

“…The next series of works are devoted to the properties studying of the active pharmaceutical ingredient of the drug "Tryfuzol" after its registration as a veterinary drug (Reg. №РП АВ-05486-01- 14) [23][24][25]. Scientists proved efficiency of 1% injectable solution in a pig at a dose of 1 ml per 10 kg of animal [23] and the 1% solution for oral use in poultry at a rate of one liter of 1% solution per a ton of water [24].…”

Section: Introductionmentioning

confidence: 99%

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Tryfuzol - New original veterinary drug

PARCHENKO¹

2017

Ankara Üniversitesi Eczacılık Fakültesi Dergisi

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SUMMARY 2-(5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazole-3-ylthio) acetate -the active pharmaceutical ingredient of new original veterinary drug "Tryfuzol". First time the molecule of the active ingredient of the drug "Tryfuzol" -piperidine 2-(5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazole-3-ylthio)acetate is mentioned in the PhD (candidate) where the method of synthesis was described, the physical-chemical properties and the acute toxicity were studied, primary pharmacological screening was conducted. At this stage scientists proved prospect for further study of the biological properties of piperidine 2-(5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazole-3-ylthio)acetate. In the work the authors investigated the possibility of qualitative and quantitative determination of compound in 1% and 2,5% solutions and publication is devoted to the developing of quantification methods of piperidine 2-(5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazole-3-ylthio)acetate by non-aqueous potentiometric titration. Interesting results about the

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tryfuzol - New original veterinary drug

PARCHENKO¹

2017

Ankara Üniversitesi Eczacılık Fakültesi Dergisi

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“…Heterocyclic systems based on 1,2,4-triazole are the subject of interest for the present-day medicinal chemistry. They have the antioxidative, hepatoprotective and other activities; moreover, some of them have been already registered and used in the presentday veterinary (tryfusol, avesstym) [1,2], and one of them is on the stage of registration for human use and manufacturing application (thiometrizol) [3].…”

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confidence: 99%

ESI-MS fragmentation pathways of some 1,2,4-triazole-3-thiones, the intermediate compounds in the synthesis of active pharmaceutical ingredients

Varynskyi

Kaplaushenko

2020

J. org. pharm. chem.

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ESI-MS fragmentation pathways of some 1,2,4-triazole-3-thiones, the intermediate compounds in the synthesis of active pharmaceutical ingredients Aim. To determine the fragmentation pathways of eight 1,2,4-triazole-3-thiones, which are intermediate products in the synthesis of active pharmaceutical ingredients of potential and registered pharmaceutical formulations. Results and discussion. HPLC-MS analysis of eight 1,2,4-triazole-3-thiones, which are intermediate products in the synthesis of salts of 1,2,4-triazolylthioacetate acids, has been carried out; the mass spectra of the compounds to be analyzed have been registered in ESI-mode with different fragmentor voltage (0, 100, 200 V). The fragmentation pathways and patterns of ion decay for compounds to be analyzed have been proposed. Experimental part. Agilent 1260 Infinity HPLC System with Agilent 6120 mass spectrometer were used. HPLC-MS conditions: column-∅4,6 × 30 mm, reversible phase Zorbax SB C18, 1.8 μm, 40 o C; mobile phase-0.1 % HCOOH in H 2 O and 0.1 % HCOOH in СH 3 CN in isocratic mode (50:50, v/v); the flow rate-0.4 mL/min; ion source-API-ES; positive polarity; drying gas-nitrogen (rate-10 L/min); the capillary voltage-4000 V; scanning in the range of m/z 100-1000. Conclusions. For the first time it has been interpreted the mass spectra of 1,2,4-triazole-3-thiones series, the intermediate compounds in the synthesis of active pharmaceutical ingredients of pharmaceutical formulations. The fragmentation pathways and patterns of eight 1,2,4-triazole-3-thiones have been shown.

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Method for Trifuzol-Neo assay determination by GC-MS

Yaroshenko

Парченко

Bihdan

et al. 2021

RJPT

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The derivatives of 1,2,4-triazole are of the great scientific interest in the fields of pharmaceutics, agricultural chemistry, and construction The production of Trifuzol-Neo has already been launched, and it is now commercially available. Compounds based on 1,2,4-triazole may also be useful in veterinary practice due to their antiviral activity. Trifuzol-Neo, or piperidinium ([5-(2-furanyl)-4-phenyl-4Н-1,2,4-triazol-3-yl]thio)acetate (Figure 1), has already proved to be an effective immunostimulator for poultry.Since that, the quality control of raw materials and the ready product is required during the production stage. Currently, there is only one method for determination of the assay of Trifuzol-Neo, which involves HPLC-DMD (Center of Medical Research Information and Patent and Licensing Practice of Ukraine. The main disadvantages of HPLC-DMD are the use of relatively high amounts of costly solvents (acetonitrile in this case), considerable baseline instability, and time-consuming system stabilization. Gas-chromatography is able to avoid these constrictions since it involves gas as a mobile phase, which is a more cost-effective and reproducible alternative. The newly developed GC/MS method for Trifuzol-Neo assay determination consists of the following steps: weighing 20.0mg of Trifuzol-Neo powder, dillution in 20mL methanol, injection of 0.5uL of the obtained solution to GC column (at least three times). The same operations are done with a Trifuzol-Neo standard.

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Antiviral activity of trifuzol for the broiler at poultry farm

Cited by 3 publications

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Tryfuzol - New original veterinary drug

Tryfuzol - New original veterinary drug

ESI-MS fragmentation pathways of some 1,2,4-triazole-3-thiones, the intermediate compounds in the synthesis of active pharmaceutical ingredients

Method for Trifuzol-Neo assay determination by GC-MS

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