Tryfuzol - New original veterinary drug

PARCHENKO, BUSHUEVA Inna;

doi:10.1501/eczfak_0000000594

Cited by 5 publications

(2 citation statements)

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“…Різні аспекти фармацевтичного ринку ЄС досліджувались в роботах таких вчених: Косенка Ю.М., Коцюмбаса І.Я., Величка В.О., Яновича Д.В., Музики В.П., Бушуєвої І.Б., та інших (Bushuieva, 2013;Velychko et al, 2014;Kosenko, 2014;Harvas & Muzyka, 2017;Bushueva et al, 2017). Поряд з тим, питання щодо системи нормативно-правового та законодавчого аспектів у сфері фармації, зокрема ветеринарної фармації у ЄС не досліджувалися.…”

Section: вступunclassified

Legislative regulatory aspects of the veterinary pharmacy market in the European Union

Harvas

2019

SMLNUVMBE

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Production of veterinary pharmacy plays an important role both in animal care and public health, such as for food safety or animal origin to prevent the spread of diseases transmitted to humans through animals. The European market for Animal Health develops rapidly filled with innovative products, updated regulatory system at the legislative level, in order to protect human health, animals and the environment. Today, the focus of attention in the European Union (EU) on the pharmaceutical industry – Is the improvement of the legal framework and its adaptation to the needs and characteristics of the veterinary pharmaceutical industry in particular. Thus Ukraine today - is an intensive process of harmonization, implementation and, at the same time, improvement of the regulatory system, in which international regulatory documents are the basis for the creation of the veterinary pharmaceutical legislation of Ukraine, according to EU requirements.

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Section: вступunclassified

Legislative regulatory aspects of the veterinary pharmacy market in the European Union

Harvas

2019

SMLNUVMBE

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“…Modern science is linked to the creation of the necessary synthetic drugs [1, 2,3]. As a result, it is possible to treat many diseases that were previously considered incurable or fatal [4,5]. Synthetic drugs in modern medicine are an important, dominant group.…”

Section: Introductionmentioning

confidence: 99%

Method of Synthesis Novel N'-Substituted- 2-((5-(Thiophen-2-Ylmethyl)-4h-1,2,4-Triazol-3-Yl)thio) Acetohydrazides

Сафонов¹

2020

Ankara Universitesi Eczacilik Fakultesi Dergisi

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Objective: The purpose of this work is to synthesize new series of N '-substituted-2-((5-(thiophen-2ylmethyl)- 4H-1,2,4-triazol-3-yl)thio)acetohydrazides.Material and Method: The compound (3) (2-((3-(thiophen-2-ylmethyl)-1H-1,2,4-triazol-5yl)thio)acetohydrazide) was synthesized by adding hydrazine hydrate to isopropyl 2- ((3-(thiophen-2-ylmethyl)-1H-1,2,4-triazol-5-yl)thio)acetate (1) and refluxed for 3-4 h in propan-2-ol. Synthesis of (5a-s) (N'-substituted-2-((3-(thiophen-2-ylmethyl)-1H-1,2,4-triazol-5-yl)thio)acetohydrazide) was carried out by adding aromatic or heterocyclic aldehyde to 2- ((3-(thiophen-2-ylmethyl)-1H-1,2,4-triazol-5-yl)thio)acetohydrazide (3) in acetic acid. The structure of synthesized compounds is confirmed using Elemental analysis (CHNS), 1 H-NMR and Chromatographic mass spectral analysis.Result and Discussion: The compound (3) was synthesized by adding hydrazine hydrate to compound (1) and compound (3) characterized by 1 H-NMR peak, as a singlet due to (NH2) at δ=2.01ppm. Synthesis of (5a-s) was carried out by adding aromatic or heterocyclic aldehyde to compound (3) in acetic acid. The signals of 1H NMR for (5a-s) are consented with the proposed structure. The elemental analysis (CHNS) was accomplished for synthesized compounds to confirm their basic chemical structures and revealed acceptable agreement with the calculated percentages.

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Synthesis, Antimicrobial and Antifungal Activity of Ylidenhydrazides of 2-((4-R-5-R1-4h-1,2,4-Triazol-3-Yl)thio)acetaldehydes

Shcherbyna¹,

Панасенко²,

Polonets³

et al. 2021

Ankara Universitesi Eczacilik Fakultesi Dergisi

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Objective:The aim of this work is the synthesis and studying of antimicrobial and antifungal properties of the ylidenhydrazides of 2- ((4-R-5-R1-4H-1,2,4-triazol-3-yl)thio)acetaldehydes with the establishment of structure-activity relationships of the synthesized compounds.Material and Method: Determination of antimicrobial and antifungal activity was performed by discdiffusion method (DDM) on series of gram positive and gram negative bacteria such as Corynebacterium pseudodiphtheriticum, Pseudomonas aeruginosa, Enterococcus faecalis, Proteus vulgaris, Escherichia coli, Salmonella spp., Staphylococcus saprophyticus, Staphylococcus aureus, Streptococcus pyogenes, Candida.Result and Discussion: A new series of ylidenhydrazides of 2-((4-R-5-R1-4H-1,2,4-triazol-3yl)thio)acetaldehydes were synthesized and their structures were confirmed by modern methods of instrumental analysis: IR and 1 H-spectroscopy, elemental analysis and GS\MS method. For 13 compounds, the antimicrobial and antifungal activities were studied on 10 strains of microorganisms in 3 different concentrations (0.1; 0.2; 0.5%). According to the results of the study, some regularities of the structureactivity relationship have been established. The obtained results can serve as a basis for the targeted search compounds with pronounced antibacterial action. An increasing the concentration of tested compounds predictably lead to increase on antimicrobial activity in almost all cases. The most active compound in our study is N'-(2-((5-methyl-4H-1,2,4-triazol-3-yl)thio)ethylidene)-4-nitrobenzohydrazide 3i (ZOI for Sta.s. and Sp in 0.5% concentration is 25 and 26 mm, respectively).

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Tryfuzol - New original veterinary drug

Cited by 5 publications

References 1 publication

Legislative regulatory aspects of the veterinary pharmacy market in the European Union

Legislative regulatory aspects of the veterinary pharmacy market in the European Union

Method of Synthesis Novel N'-Substituted- 2-((5-(Thiophen-2-Ylmethyl)-4h-1,2,4-Triazol-3-Yl)thio) Acetohydrazides

Synthesis, Antimicrobial and Antifungal Activity of Ylidenhydrazides of 2-((4-R-5-R1-4h-1,2,4-Triazol-3-Yl)thio)acetaldehydes

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