Antiviral Activity of Solanum paniculatum Extract and Constituents

Valadares, Ydia Mariele; Brandão, Geraldo Célio; Kroon, Erna Geessien; Filho, José D. Souza; Oliveira, Alaı́de Braga de; Braga, Fernão Castro

doi:10.1515/znc-2009-11-1210

Cited by 24 publications

(15 citation statements)

References 16 publications

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“… Compounds Plant sources Parts Biological properties References Steroidal Saponins 1 Chlorogenone S. torvum Fruit [ 430 ] 2 (5 α ,25 S )-Spirostan-3,6-dione S. torvum Fruit [ 430 ] 3 Solakhasoside S. khasianum Fruit [ 431 ] 4 Foliumin S. amygdalifolium Aerial [ 57 ] 5 Foliumin A S. amygdalifolium Aerial [ 56 ] 6 Neotigogenin S. paniculatum Leaf Cytotoxic [ 257 ] 7 Diuranthoside A S. cathayanum Root [ 432 ] 8 Torvoside N S. torvum Aerial Anticancer [ 316 ] 9 Atroposide E …”

Section: Chemical Constituents and Their Biological Propertiesmentioning

confidence: 99%

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Kaunda

Zhang

2019

Nat. Prod. Bioprospect.

103

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Over the past 30 years, the genus Solanum has received considerable attention in chemical and biological studies. Solanum is the largest genus in the family Solanaceae, comprising of about 2000 species distributed in the subtropical and tropical regions of Africa, Australia, and parts of Asia, e.g., China, India and Japan. Many of them are economically significant species. Previous phytochemical investigations on Solanum species led to the identification of steroidal saponins, steroidal alkaloids, terpenes, flavonoids, lignans, sterols, phenolic comopunds, coumarins, amongst other compounds. Many species belonging to this genus present huge range of pharmacological activities such as cytotoxicity to different tumors as breast cancer (4T1 and EMT), colorectal cancer (HCT116, HT29, and SW480), and prostate cancer (DU145) cell lines. The biological activities have been attributed to a number of steroidal saponins, steroidal alkaloids and phenols. This review features 65 phytochemically studied species of Solanum between 1990 and 2018, fetched from SciFinder, Pubmed, ScienceDirect, Wikipedia and Baidu, using “Solanum” and the species’ names as search terms (“all fields”).

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Section: Chemical Constituents and Their Biological Propertiesmentioning

confidence: 99%

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Kaunda

Zhang

2019

Nat. Prod. Bioprospect.

103

View full text Add to dashboard Cite

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“…9,10 Pharmacological studies indicate that S. paniculatum root extract is able to inhibit gastric secretion in pylorus-ligated mice as well as to be effective against ulcer induced by stress in mice, both activities being related to the high concentration of 3-aminospirostane steroidal alkaloids. 8 Further biological activities such as antiviral, 11 anti-inflammatory 5 and anticarcinogenic effects 12 have been described elsewhere.…”

Section: Introductionmentioning

confidence: 99%

Characterization of 3‐aminospirostane alkaloids from roots of Solanum paniculatum L. with hepatoprotective activity

Gazolla

Marques

Silva

et al. 2020

Rapid Comm Mass Spectrometry

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Rationale Solanum paniculatum L., popularly known as jurubeba, has traditionally been used in Brazilian folk medicine for liver diseases. However, there is a lack of knowledge about the chemical characterization of 3‐aminospirostane alkaloids, an important class related to pharmacological activities. This work aimed to characterize the alkaloids using liquid chromatography with tandem mass spectrometry (LC/MS/MS) supported by molecular networking and theoretical calculations as well as to evaluate the contribution to hepatoprotective activity. Methods S. paniculatum roots were collected and macerated with MeOH/H2O (8:2) obtaining the crude extract (SP‐CE). From this, partition using EtOAc with pH variation yielded the alkaloidic fraction (SP‐AF). Both were evaluated in an acute liver injury model (100 and 200 mg/kg), after intraperitoneal administration of carbon tetrachloride (CCl4) in mice. AST (aspartate transaminase) and ALT (alanine transaminase) serum levels were investigated, as well as the histopathological characteristics. The SP‐CE and SP‐AF were analyzed by LC/MS/MS, using quadrupole/time‐of‐flight and ion‐trap systems. The alkaloids annotated by the GNPS molecular network had their structures defined using gas‐phase ionization and fragmentation reaction supported by theoretical calculations. Results The SP‐CE and SP‐AF decreased the ALT serum levels compared with the negative control. The group treated with the SP‐CE (at the highest dose) demonstrated a significant decrease of ALT. Hepatic cell degeneration decrease was observed mainly at the highest dose of the treatment. Detailed electrospray ionization MS/MS data allowed us to identify alkaloids not previously reported, to propose their gas‐phase reactions and to redefine the initial open ring fragmentation mechanism of the steroidal alkaloids with the jurubidine moiety. Conclusions The results allowed us to identify seven steroidal alkaloids from jurubeba and redefine the initial mechanism of fragmentation. A significant hepatoprotective effect was also demonstrated, corroborating its traditional use.

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“…Valadares et al investigated the antiviral effect of S. paniculatum against murine encephalomyocarditis virus (EMCv), human herpes virus type 1 (HHV-1), and vaccinia virus strains Western Reserve (VACV-WR). According to the results, the extract of S. paniculatum inhibited the replication of HHV-1, but exhibited no effect on VACV-WR and EMCv (Valadares et al, 2009). Javid et al also studied the anti HCV activity of chloroform extract of S. nigrum seeds (SNS).…”

Section: Anthocyaninsmentioning

confidence: 98%

The Signaling Pathways, and Therapeutic Targets of Antiviral Agents: Focusing on the Antiviral Approaches and Clinical Perspectives of Anthocyanins in the Management of Viral Diseases

et al. 2019

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As the leading cause of death worldwide, viruses significantly affect global health. Despite the rapid progress in human healthcare, there are few viricidal and antiviral therapies that are efficient enough. The rapid emergence of resistance, and high costs, as well as the related side effects of synthetic antiviral drugs, raise the need to identify novel, effective, and safe alternatives against viral diseases. Nature has been of the most exceptional help and source of inspiration for developing novel multi-target antiviral compounds, affecting several steps of the viral life cycle and host proteins. For that matter and due to safety and efficacy limitations, as well as high resistance rate of conventional therapies, hundreds of natural molecules are preferred over the synthetic drugs. Besides, natural antiviral agents have shown acceptable antiviral value in both preclinical and clinical trials.This is the first review regarding molecular and cellular pathways of the virus life cycle, treatment strategies, and therapeutic targets of several viral diseases with a particular focus on anthocyanins as promising natural compounds for significant antiviral enhancements. Clinical applications and the need to develop nano-formulation of anthocyanins in drug delivery systems are also considered.

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Antiviral Activity of Solanum paniculatum Extract and Constituents

Cited by 24 publications

References 16 publications

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Characterization of 3‐aminospirostane alkaloids from roots of Solanum paniculatum L. with hepatoprotective activity

The Signaling Pathways, and Therapeutic Targets of Antiviral Agents: Focusing on the Antiviral Approaches and Clinical Perspectives of Anthocyanins in the Management of Viral Diseases

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