Antiviral activity of selected flavonoids against Chikungunya virus

Lani, Rafidah; Hassandarvish, Pouya; Shu, Meng-Hooi; Phoon, Wai Hong; Chu, Justin Jang Hann; Higgs, Stephen; Vanlandingham, Dana L.; Bakar, Sazaly Abu; Zandi, Keivan

doi:10.1016/j.antiviral.2016.07.009

Cited by 132 publications

(83 citation statements)

References 30 publications

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“…Fisetin possessed post-infection anti-CHIKV activity by the inhibition of NS proteins 1 and 3 in a dose-dependent manner. Moreover, it was observed that CHIKV E2 protein and its precursor pE2 were also downregulated during treatment with fisetin [21]. Similarly, a decreased replication process of DENV-2 was observed when Vero cells were treated with fisetin after DENV-2 infection.…”

Section: Flavonoids Against Non-picornavirusesmentioning

confidence: 95%

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Lalani

Poh

2020

Viruses

153

101

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Flavonoids are natural biomolecules that are known to be effective antivirals. These biomolecules can act at different stages of viral infection, particularly at the molecular level to inhibit viral growth. Enterovirus A71 (EV-A71), a non-enveloped RNA virus, is one of the causative agents of hand, foot and mouth disease (HFMD), which is prevalent in Asia. Despite much effort, no clinically approved antiviral treatment is available for children suffering from HFMD. Flavonoids from plants serve as a vast reservoir of therapeutically active constituents that have been explored as potential antiviral candidates against RNA and DNA viruses. Here, we reviewed flavonoids as evidence-based natural sources of antivirals against non-picornaviruses and picornaviruses. The detailed molecular mechanisms involved in the inhibition of EV-A71 infections are discussed.

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Section: Flavonoids Against Non-picornavirusesmentioning

confidence: 95%

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Lalani

Poh

2020

Viruses

153

101

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“…The inhibition of hepatitis C virus and the human (2016), Gómez-Calderón et al (2017) cytomegalovirus (HCMV) infection was done by the activity of quercetagetin (Zakaryan et al 2017). Moreover, baicalein, quercetagetin, and fisetin were also reported for the inhibition of chikungunya virus by impeding the intracellular viral replication at early stages (Lani et al 2016). Phenolic acids have shown significant antiviral activity against HSV-1 very significantly (Medini et al 2016).…”

Section: Flavonoids As Antiviral Agentsmentioning

confidence: 99%

Phytochemicals as Antiviral Agents: Recent Updates

Ghildiyal

Prakash

Chaudhary

et al. 2020

Plant-Derived Bioactives

124

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“…These data provide the first evidence of the intracellular anti-CHIKV activities of these compounds [68]. The CHIKV replicon cell line, BHKCHIKV-NCT, was validated and used for screening 356 compounds, including 123 natural compounds and 233 clinically approved drugs and other pharmaceutical compounds.…”

Section: Indirect Inhibitory Activities Of Compounds and Extracts Agamentioning

confidence: 90%

Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses

Oliveira

Teixeira

Oliveira

et al. 2017

Preprint

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Abstract:Dengue virus (DENV) and chikungunya virus (CHIKV) are reemergent arboviruses that are transmitted by mosquitoes of the Aedes genus. During the last several decades, these viruses have been responsible for millions of cases of infection and thousands of deaths worldwide. Therefore, several investigations were conducted over the past few years to find antiviral compounds for the treatment of DENV and CHIKV infections. One attractive strategy is the screening of compounds that target enzymes involved in the replication of both DENV and CHIKV. In this review, we describe advances in the evaluation of natural products targeting the enzymes involved in the replication of these viruses.

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Antiviral activity of selected flavonoids against Chikungunya virus

Cited by 132 publications

References 30 publications

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Phytochemicals as Antiviral Agents: Recent Updates

Potential Antivirals: Natural Products Targeting Replication Enzymes of Dengue and Chikungunya Viruses

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