Antiviral activity of Plantago major extracts and related compounds in vitro

Chiang, Lien-Chai; Chiang, Wen Chin; Chang, Mei-Yin; Ng, Lean‐Teik; Lin, Chun‐Ching

doi:10.1016/s0166-3542(02)00007-4

Cited by 268 publications

(201 citation statements)

References 36 publications

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“…Phenolic constituents like caffeic acid and chlorogenic acid possess strong inhibitory effect on herpesvirus (HSV-1, HSV-2) and adenovirus (ADV-3, ADV-11) (Chiang et al, 2002).…”

Section: Chlorogenic Acid Isolated From the Leaves Also Have Shown Rementioning

confidence: 99%

A review of the pharmacological effects of Arctium lappa (burdock)

et al. 2010

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Abstract. Arctium lappa, commonly known as burdock, is being promoted/recommended as a healthy and nutritive food in Chinese societies. Burdock has been used therapeutically in Europe, North America and Asia for hundreds of years. The roots, seeds and leaves of burdock have been investigated in view of its popular uses in Traditional Chinese Medicine (TCM). In this review, the reported therapeutic effects of the active compounds present in the different botanical parts of burdock are summarized. In the root, the active ingredients have been found to "detoxify" blood in TCM term and promote blood circulation to the skin surface, improving the skin quality/texture and curing skin diseases like eczema. Antioxidants and anti-diabetic compounds have also been found in the root. In the seeds, some active compounds possess anti-inflammatory effects, and potent inhibitory effects on the growth of tumors such as the pancreatic carcinoma. In the leaf extract, the active compounds isolated can inhibit the growth of micro-organisms in the oral cavity. The medicinal uses of burdock in treating chronic diseases like cancers, diabetes and AIDS have been reported. However, it is also essential to be aware of the side-effects of burdock including contact dermatitis and other allergic/inflammatory responses that might be evoked by burdock.

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“…Phenolic constituents like caffeic acid and chlorogenic acid possess strong inhibitory effect on herpesvirus (HSV-1, HSV-2) and adenovirus (ADV-3, ADV-11) (Chiang et al, 2002).…”

Section: Chlorogenic Acid Isolated From the Leaves Also Have Shown Rementioning

confidence: 99%

A review of the pharmacological effects of Arctium lappa (burdock)

et al. 2010

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“…Some researchers reported that P. major contains biologically active chemical compounds such as polysaccharides, lipids, caffeic acid derivatives, flavonoids, iridoids glycosides, and terpenoids. Alkaloids and some organic acids have also been identified in this plant [8][9][10][11][12][13][14][15][16][17][18]. This study also observed that highest anti-inflammatory activity was found in the ME at a dose of 900 mg/kg.…”

Section: In Vivo Anti-inflammatory Activitymentioning

confidence: 54%

“…It is well-known traditional herbal plant to treat various diseases including skin diseases, infectious diseases, reduce pain and fever, reproduction, cancer, respiratory and digestive organs related problems [8]. In addition to the traditional uses of P. major, some researchers also prove its medicinal properties such as immune modulating property [13], antileukemia, antiviral, anticarcinogenic [14,15], antioxidant [16], anti-inflammatory, and analgesic activities [17]. These medicinal properties of P. major due to the presence of biologically active chemical compounds such as polysaccharides, lipids, caffeic acid derivatives, flavonoids, iridoid glycosides, terpenoids, alkaloids, and some organic acids [8,12,18].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Evaluation of Anti-Inflammatory Activity of Aerial Part Extracts of Plantago Major L.

Vandana¹,

Gupta²,

Mukerjee³

2017

Asian J Pharm Clin Res

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Objective: This study aims to perform phytochemical screening and investigate anti-inflammatory activity of extract from aerial part of the plant Plantago major L.Methods: Preliminary phytochemical screening of plant extract was carried out using standard qualitative procedures and anti-inflammatory activity was evaluated using carrageenan-induced paw edema model in male Wistar albino rats using plethysmometer. Diclofenac sodium (10 mg/kg, b.w.) was used as standard drug.Results: Preliminary phytochemical screening of the different extracts revealed that they were rich in secondary metabolite compounds such as carbohydrates, tannins, steroids, flavonoids, terpenoids, glycosides, fats and oils, alkaloids, phenolic compounds, and iridoid glycosides. The antiinflammatory activity was evaluated using carrageenan-induced paw edema models in Wistar albino rats. The anti-inflammatory activity of methanolic extract (ME) was found to be dose dependent in carrageenan-induced paw edema model. The ME has shown significant (p<0.05) inhibition of paw edema, 61.11% and 55.55% on 4 th hr at the doses of 900 and 600 mg/kg, respectively. Conclusion:The results of the present study demonstrate that ME of the aerial parts of the plant possess significant (p<0.05) anti-inflammatory potential.

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“…The 4-fold dilutions of the methanol extract incubated with confluent cell monolayers in 96-well plates and were observed microscopically for changes in cell morphology and viability at 24, 48 and 72 hours of incubation (Chiang et al, 2002). The cytopathic effect was scored under an inverted microscope.…”

Section: Cytotoxicitymentioning

confidence: 99%

Phytochemical, antioxidant, antiviral and cytotoxic evaluation of <i>Opuntia dillenii</i> flowers

Kumar

Ganesh

Peng

et al. 2014

Bangladesh J Pharmacol

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Opuntia dillenii used in Asian traditional medicine especially in China. We here report on the investigation of the phytochemical content, anti-oxidant, cytotoxicity and antiviral activity of methanolic extract of O. dillenii flowers. The anti-oxidant activity was measured with the DPPH, hydrogen peroxide and hydroxyl radicals scavenging method. In the antiviral and cytotoxic assay we used different viruses in different cell lines. In anti-oxidant assay, the DPPH assay exhibited potent anti-oxidant abilities with IC50 of 58.7 µg/mL. In antiviral assay, the extract possess strongest antiviral activity against herpes simplex 1 (EC50= 25 µg/mL) and 2 (EC50= 20 µg/mL), vaccinia (EC50= 100 µg/ mL) and moderate activity for remaining viruses (EC50= >100 µg/mL). The cytotoxicity effect was evaluated using MTT assay and the results revealed that the extracts exhibited cytotoxicity above the range of 100 µg/mL. Our present reports confirmed that the O. dillenii could be a potential anti-oxidant and antimicrobial agent in near future. Article Info

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Antiviral activity of Plantago major extracts and related compounds in vitro

Cited by 268 publications

References 36 publications

A review of the pharmacological effects of Arctium lappa (burdock)

A review of the pharmacological effects of Arctium lappa (burdock)

Phytochemical Screening and Evaluation of Anti-Inflammatory Activity of Aerial Part Extracts of Plantago Major L.

Phytochemical, antioxidant, antiviral and cytotoxic evaluation of <i>Opuntia dillenii</i> flowers

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