Antiviral activity of <i>Cenostigma pluviosum</i> var. <i>peltophoroides</i> extract and fractions against SARS-CoV-2

Philippsen, Gisele Strieder; Araújo, Ingrid Garcia de; Moraes, Carolina Borsoi; Barbosa, Cecília Gomes; Freitas‐Junior, Lúcio H.; Guidi, Ana Carolina; Mello, João Carlos Palazzo de; Peralta, Rosane Marina; Fernandez, Maria Aparecida; Teixeira, Róbson Ricardo; Seixas, Flávio Augusto Vicente

doi:10.1080/07391102.2022.2120078

Cited by 5 publications

(3 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 56 , may highlight a preventive role of this class of compounds through their interference with other mechanisms of viral infection, such as the interaction of the spike protein with the ACE2 receptor. 62 , 63 …”

Section: Resultsmentioning

confidence: 99%

The hope and hype of ellagic acid and urolithins as ligands of SARS-CoV-2 Nsp5 and inhibitors of viral replication

Bianconi,

Gidari,

Souma

et al. 2023

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

Non-structural protein 5 (Nsp5) is a cysteine protease that plays a key role in SARS-CoV-2 replication, suppressing host protein synthesis and promoting immune evasion. The investigation of natural products as a potential strategy for Nsp5 inhibition is gaining attention as a means of developing antiviral agents. In this work, we have investigated the physicochemical properties and structure-activity relationships of ellagic acid and its gut metabolites, urolithins A–D, as ligands of Nsp5. Results allow us to identify urolithin D as promising ligand of Nsp5, with a dissociation constant in the nanomolar range of potency. Although urolithin D is able to bind to the catalytic cleft of Nsp5, the appraisal of its viral replication inhibition against SARS-CoV-2 in Vero E6 assay highlights a lack of activity. While these results are discussed in the framework of the available literature reporting conflicting data on polyphenol antiviral activity, they provide new clues for natural products as potential viral protease inhibitors.

show abstract

Section: Resultsmentioning

confidence: 99%

The hope and hype of ellagic acid and urolithins as ligands of SARS-CoV-2 Nsp5 and inhibitors of viral replication

Bianconi,

Gidari,

Souma

et al. 2023

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

show abstract

“…peltophoroides on SARS-CoV was investigated. It was reported that the ethyl acetate extract obtained from the plant species used was 100% effective [134]. The effect on SARS-CoV was investigated by using different plant species in Belgium.…”

Section: Coronavirus (Family: Coronaviridae)mentioning

confidence: 99%

“…Plants effective against coronavirus[42,61,68,[116][117][118][119][120][121][122][123][124][125][126][127][128][129][130][131][132][133][134][135].Aegle marmelos, Aesculus hippocastanum, Allium sativum, Aloe vera, Anastatica hierochuntica, Asteriscus hierochunticus, Azadirachta indica, Bombax ceiba, Camellia sinesis, Cannabis sativa, Cenostigma pluviosum subsp. peltophoroides, Cinnamomum verum, Citrus reticulata, Citrus sinensis, Cupressus sempervirens, Curcuma longa, Cyperus rotundus, Echinaceae purpurea, Eucalyptus globulus, Filipendula ulmaria, Gingko biloba, Glycyrrhiza glabra, Guaiacum officinale, Hibiscus sabdariffa, Houttuynia cordata, Juniperus oxycedrus, Justicia adhatoda, Kickxia aegyptiaca, Laurus nobilis, Mentha piperita, Moringa oleifera, Morus alba subsp.…”

mentioning

confidence: 99%

A Review on Antiviral Plants Effective Against Different Virus Types

Mohammed¹,

Uysal²,

Sevindik³

2023

pps

View full text Add to dashboard Cite

The treatment of microbial infections has proven challenging for humans in recent years. Synthetic medications, such as antimicrobial agents, are used for treating these infections. Antimicrobials derived from natural sources have gained popularity as an alternative to manufactured medications due to their lack of adverse effects. Plants, which play a significant role in this setting, have historically served as a reliable natural defence against several pathogens. In this study, studies on plants used against viral diseases are mentioned. Studies on viruses that cause disease have been compiled in the literature. According to the findings, it has been reported in the literature that many different plant species are effective against herpes simplex virus (HSV-1, HSV-2), human immunodeficiency virus (HIV), influenza virus (A, B) and parainfluenza, Poliovirus, Astrovirus, Parvovirus, Sindbis virus (SINV), Feline calicivirus (FCV), Rhinovirus, Echovirus, Rotavirus, Bovine alphaherpesvirus 1 (BoHV-1), Reovirus, Vaccinia virus (VACV), Cardiovirus A (Encephalomyocarditis virus; EMCV), Coxsackie virus, Semliki forest, Measles virus, Newcastle disease virus (NDV), Coronavirus, Adenovirus (ADV-3, ADV-5, ADV-8, ADV -11), Canine distemper virus (CDV), Lumpy skin disease virus (LSDV), Hepatitis A, B, C virus and Enterovirus. To combat viruses, plants can be considered a potentially invaluable natural resource.

show abstract

Traditional Herbal Medicines and Their Active Constituents in Combating SARS-CoV-2 Infection

Shivangani,

Lakshmi,

Jamir

et al. 2023

Ethnopharmacology and Drug Discovery for COVID-19: Anti-Sars-CoV-2 Agents From Herbal Medicines and Natural Products

View full text Add to dashboard Cite

Antiviral activity of Cenostigma pluviosum var. peltophoroides extract and fractions against SARS-CoV-2

Cited by 5 publications

References 67 publications

The hope and hype of ellagic acid and urolithins as ligands of SARS-CoV-2 Nsp5 and inhibitors of viral replication

The hope and hype of ellagic acid and urolithins as ligands of SARS-CoV-2 Nsp5 and inhibitors of viral replication

A Review on Antiviral Plants Effective Against Different Virus Types

Traditional Herbal Medicines and Their Active Constituents in Combating SARS-CoV-2 Infection

Contact Info

Product

Resources

About