Antiviral activity of glycyrrhizic acid

Pompei, Raffaello; Pani, Alessandra; Flore, Ornella; Marcialis, Maria Antonietta; Loddo, B

doi:10.1007/bf01952290

Cited by 52 publications

(20 citation statements)

References 4 publications

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“…The minimum concentration for which inhibition was observed proved to be non-toxic for the pig's kidney (PS) cell lines and human cervical cancer (HeLa). The ability of GA to inhibit the replication of a number of other viruses is also established: vaccinia virus, herpes simplex virus type 1, Newcastle disease virus, poliovirus type 1, and vesicular stomatitis virus (Pompei et al, 1979(Pompei et al, , 1980. These studies were performed in vitro on the human aneuploid cell line Hep2.…”

Section: Antiviral Activity Of Glycyrrhizic Acidmentioning

confidence: 99%

Glycyrrhizic acid as a multifunctional drug carrier – From physicochemical properties to biomedical applications: A modern insight on the ancient drug

Selyutina

Polyakov

2019

International Journal of Pharmaceutics

148

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A B S T R A C TGlycyrrhizic acid is the main active component of Licorice root which has been known in traditional Chinese and Japanese medicine since ancient times. In these cultures glycyrrhizic acid (GA) is one of the most frequently used drugs. However, only in 21-st century a novel unusual property of the GA to enhance the activity of other drugs has been discovered. The review describes briefly the experimental evidences of wide spectrum of own biological activities of glycyrrhizic acid as well as discusses the possible mechanisms of the ability of GA to enhance the activity of other drugs. We have shown that due to its amphiphilic nature GA is able to form self-associates in aqueous and non-aqueous media, as well as water soluble complexes with a wide range of lipophilic drugs. The main purpose of our review is to focus reader's attention on physicochemical studies of the molecular mechanisms of GA activity as a drug delivery system (DDS). In our opinion, the most intriguing feature of glycyrrhizic acid which might be the key factor in its therapeutic activity is the ability of GA to incorporate into the lipid bilayer and to increase the membrane fluidity and permeability. The ability of biomolecules and their aggregates to change the properties of cell membranes is of great significance, from both fundamental and practical points of view. monstrated the ability of GA to interact with cell membrane and to https://doi.

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Section: Antiviral Activity Of Glycyrrhizic Acidmentioning

confidence: 99%

Glycyrrhizic acid as a multifunctional drug carrier – From physicochemical properties to biomedical applications: A modern insight on the ancient drug

Selyutina

Polyakov

2019

International Journal of Pharmaceutics

148

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“…Glycyrrhiza exerts antiviral activity in vitro toward a number of viruses, including hepatitis A, [15] varicellazoster, [16] HIV, [17] herpes simplex type 1, Newcastle disease, and vesicular stomatitis viruses. [18,19] Glycyrrhiza is well tolerated by most patients at normal doses (1-4 g/d crude herb).…”

Section: Glycyrrhiza Glabra (Liquorice)mentioning

confidence: 99%

Hepatoprotective Models and Various Natural Product Used in Hepatoprotective Agents: a Review

Bansal¹,

Kumar²,

Malviya³

et al. 2014

Phcog Commn.

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“…The full or selective esterification of hydroxyl groups of the carbohydrate part of GL, its salts or trimethyl ester (17) was carried out using chlorides of various aromatic acids in pyridine, pyridine -triethylamine or pyridine -tributylamine to form esters (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42) [66,67].…”

Section: Synthesis Of Glycyrrhizic Acid Estersmentioning

confidence: 99%

“…GL and its monoammonium salt inhibited the growth of some DNA and RNA viruses and inactivated Herpes simplex virus particles in vitro [31,32]. GL increased the survival of mice with herpes simplex encephalitis [33].…”

Section: Introductionmentioning

confidence: 99%

Chemical Modification of Glycyrrhizic Acid As A Route to New Bioactive Compounds for Medicine

Балтина

2003

CMC

222

160

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Glycyrrhizic Acid (GL) is the major bioactive triterpene glycoside of licorice root (Glycyrrhiza Radix) extracts possessing a wide range of pharmacological properties (anti-inflammatory, anti-ulcer, anti-allergic, anti-dote, anti-oxidant, anti-tumor, anti-viral etc.). Official sources of GL are Glycyrrhiza glabra L. and Gl. uralensis Fish. (Leguminosae). The content of GL in licorice root is 2-24% of the dry weight. GL is one of the leading natural compounds for clinical trials of chronic active viral hepatitis and HIV infections (preparation Stronger Neo-Minophagen C, SNMC), and its monoammonium salt (glycyram, tussilinar) is used as an anti-inflammatory and anti-allergic remedy. The synthetic transformations of GL on carboxyl and hydroxyl groups were carried out to produce new bioactive derivatives for medicine. GL esters were produced containing fragments of bioactive acids (4-nitrobenzoic, cinnamic, salycilic, acetylsalycilic, nicotinic, isonicotinic). Bioactive amides of GL were synthesized using chloroanhydride technique and N,N'-diciclohexylcarbodiimide (DCC) method. The synthesis of acylthioureids and semicarbazones was carried out via the reaction of triacylisothiocianate of penta-O-acetyl-GL with primary amines and hydrazines. The chain of transformations of trichloranhydride of penta-O-acetyl-GL was made with the introduction of diazoketone groups in the molecule. A new group of GL derivatives to be triterpene glycopeptides was prepared by the activated esters method (N-hydrohysuccinimide-DCC or N-hydroxybenzotriazol-DCC) using alkyl (methyl, ethyl, propyl, butyl, tert-butyl) or benzyl (4-nitrobenzyl) esters of amino acids. The glycyrrhizyl analogs of the known immunostimulator, N-acetyl-muramoyldipeptide (MDP), were synthesized using Reagent Woodward K. A series of ureids and carbamates of GL was synthesized containing 5-amino-5-desoxy-D-xylopyranose units. The synthesis of 4-nitro-4-desoxy-glycosides, modified analogs of GL, was carried out by the oxidative splitting of the carbohydrate part of GL with NaIO(4). Triterpene 2-desoxy-D-glycosides, analogs of GL, were prepared by the glycal method in the presence of iodine-containing promoters or sulfonic acid cation-exchange resin KU-2-8 (H+) and LiBr. New anti-inflammatory and anti-ulcer agents were found among GL derivatives such as esters, amides, ureids, carbamates, thioureids and glycopeptides. GL glycopeptides are of interest as immunomodulators. Some of the chemically modified GL derivatives (salts, amides, glycopeptides) were potent HIV-1 and HIV-2 inhibitors in vitro. Preparation niglizin (penta-O-nicotinate of GL) was studied clinically as an anti-inflammatory agent and is of interest for studies as hepatoprotector and HIV inhibitor.

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Antiviral activity of glycyrrhizic acid

Abstract: Glycyrrhizic acid inhibits the growth of several DNA and RNA viruses in cell cultures and inactivates Herpes simplex 1 virus irreversibly.

Cited by 52 publications

References 4 publications

Glycyrrhizic acid as a multifunctional drug carrier – From physicochemical properties to biomedical applications: A modern insight on the ancient drug

Glycyrrhizic acid as a multifunctional drug carrier – From physicochemical properties to biomedical applications: A modern insight on the ancient drug

Hepatoprotective Models and Various Natural Product Used in Hepatoprotective Agents: a Review

Chemical Modification of Glycyrrhizic Acid As A Route to New Bioactive Compounds for Medicine

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