Antiviral activity of cuprous oxide nanoparticles against Hepatitis C Virus in vitro

Hang, Xiaofeng; Peng, Haoran; Song, Hongyuan; Qi, Zhongtian; Miao, Xiangshui; Xu, Wei

doi:10.1016/j.jviromet.2015.06.010

Cited by 153 publications

(111 citation statements)

References 35 publications

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“…This study revealed that CO-NPs blocked HCV attachment and entry. They hypothesized that CO-NP probably interacts with the surface of virion that in turn blocks the receptor binding sites present on the HCV envelope and thus prevent viral attachment [58]. …”

Section: Nanoparticles As Carrier For Anti-hcv Sirnamentioning

confidence: 99%

Hepatitis C virus management: potential impact of nanotechnology

Elberry

Darwish

Mousa

2017

Virol J

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Around 170–200 million individuals have hepatitis C virus (HCV), which represents ~ 3% of the world population, including ~ 3–5 million people in the USA. According to the WHO regional office in the Middle East, Egypt has the highest prevalence in the world, with 7% prevalence in adults. There had been no effective vaccine for HCV; a combination of PEG-Interferon and ribavirin for at least 48 weeks was the standard therapy, but it failed in more than 40% of the patients and has a high cost and serious side effects. The recent introduction of direct-acting antivirals (DAA) resulted in major advances toward the cure of HCV. However, relapse and reduced antiviral efficacy in fibrotic, cirrhotic HCV patients in addition to some undesired effects restrain the full potential of these combinations. There is a need for new approaches for the combinations of different DAA and their targeted delivery using novel nanotechnology approaches. In this review, the role of nanoparticles as a carrier for HCV vaccines, anti-HCV combinations, and their targeted delivery are discussed.

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Section: Nanoparticles As Carrier For Anti-hcv Sirnamentioning

confidence: 99%

Hepatitis C virus management: potential impact of nanotechnology

Elberry

Darwish

Mousa

2017

Virol J

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“…Moreover, metal nanoparticles were found to be virucidal against DNA and RNA viruses. Metal nanoparticles such as silver and gold have demonstrated efficient inhibitory activity against Human Immunodeficiency Virus, Hepatitis B Virus, influenza virus and Peste des petits ruminants virus (Hang et al 2015). Hang et al (2015) demonstrated that cuprous nanoparticle (at cytotoxic concentration) significantly inhibited Hepatitis C virus infection in the HCVcc/Huh7.5.1 cell culture system.…”

Section: Disscusionmentioning

confidence: 99%

“…Metal nanoparticles such as silver and gold have demonstrated efficient inhibitory activity against Human Immunodeficiency Virus, Hepatitis B Virus, influenza virus and Peste des petits ruminants virus (Hang et al 2015). Hang et al (2015) demonstrated that cuprous nanoparticle (at cytotoxic concentration) significantly inhibited Hepatitis C virus infection in the HCVcc/Huh7.5.1 cell culture system. Furthermore, it was indicated that cuprous oxide, sulphide, iodide and chloride have highly efficient antiviral activities- on bacteriophage QB (Sunada et al 2012).…”

Section: Disscusionmentioning

confidence: 99%

“…Possible mechanisms of the antiviral activity include: interaction with the viral surface, interference with the viral attachment, inhibition of virus penetration into the cell, interaction with the viral genome, inhibition of genome replication, inhibition of protein synthesis and inhibition of assembly and release of virions (Hang et al 2015). In this study, we demonstrated a decrease in number of copies of DNA of HSV after a 48 h of incubation or RNA of BVDV after 5 days of incubations.…”

Section: Disscusionmentioning

confidence: 99%

“…Chromium(III) and iron(III) are essential trace elements in the human body, which play a crucial role in the biochemistry of all living organisms (Hang et al 2015). Nutrition plays an important role in the development and also in the prevention of cancer, cardiovascular diseases, and diabetes.…”

Section: Disscusionmentioning

confidence: 99%

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Chromium(III) and iron(III) inhibits replication of DNA and RNA viruses

Terpiłowska

Siwicki

2017

Biometals

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The aim of this study was to examine the effect of treating of chromium(III) and iron(III) and their combinations on Herpes Simplex Virus type 1 (HSV-1) and Bovine Viral Diarrhoea virus (BVDV) replication. The antiviral efficacies of chromium(III) and iron(III) on HSV-1 and BVDV were evaluated using Real Time PCR method. Moreover, the cytotoxicity of these microelements was examined using the MTT reduction assay. The IC50 (50% inhibiotory concentration) for the chromium chloride was 1100 μM for Hep-2 cells and 1400 μM for BT cells. The IC50 for the iron chloride was 1200 μM for Hep-2 cells and more than1400 μM for BT cells. The concentration-dependent antiviral activity of chromium chloride and iron chloride against HSV-1 and BVDV viruses was observed. In cultures simultaneously treated with (1) 200 μM of CrCl3 and 1000 μM of FeCl3, (2) 1000 μM of CrCl3 and 200 μM of FeCl3, (3) 400 μM of CrCl3 and 800 μM of FeCl3, (4) 800 μM of CrCl3 and 400 μM of FeCl3 a decrease in number of DNA or RNA copies was observed compared with control cells and cells incubated with chromium(III) and iron(III) used separately. The synergistic antiviral effects were observed for chromium(III) and iron(III) against HSV-1 and BVDV.

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Green Synthesis of Copper and Copper‐Based Nanoparticles for Their Use in Medicine

Mallick

Sabui

2021

Nanotechnology in Medicine

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Antiviral activity of cuprous oxide nanoparticles against Hepatitis C Virus in vitro

Cited by 153 publications

References 35 publications

Hepatitis C virus management: potential impact of nanotechnology

Hepatitis C virus management: potential impact of nanotechnology

Chromium(III) and iron(III) inhibits replication of DNA and RNA viruses

Green Synthesis of Copper and Copper‐Based Nanoparticles for Their Use in Medicine

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