Antiviral activity of carrageenan on hepatitis A virus replication in cell culture

Girond, S.; Crance, Jean‐Marc; Cuyck-Gandre, H. Van; Renaudet, J.; Deloince, R.

doi:10.1016/0923-2516(91)90011-q

Cited by 87 publications

(52 citation statements)

References 24 publications

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“…In this study, we have investigated the anti-malarial activity and anti-adhesive capacity of a panel of polysaccharides including four seaweed extracts; fucoidan, carrageenan CSW-2 (k), LP-42 (i), and MB73-F (j). The carrageenans have previously been shown to interfere with adhesion of Helicobacter pylori to heparan sulphate and have demonstrated antiviral activity against herpes simplex (1 and 2) and hepatitis A (Girond et al 1991;Utt 1997;Carlucci et al 1999).…”

Section: Resultsmentioning

confidence: 99%

Carrageenans inhibit the in vitro growth of Plasmodium falciparum and cytoadhesion to CD36

et al. 2005

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Carbohydrates are implicated in many of the invasive and adhesive interactions that occur between Plasmodium falciparum malaria parasites and human host cells, including invasion of sporozoites into hepatocytes, entry of merozoites into new host erythrocytes during asexual blood-stage replication, adhesion of infected erythrocytes to uninfected erythrocytes (rosetting) and to a number of host endothelial receptors including ICAM-1, CD36 and chondroitin-4-sulphate. In addition to increasing our understanding of host-parasite interactions, the investigation of carbohydrates with differing levels and patterns of sulphation as inhibitors may contribute to the development of novel therapeutics targeting malaria. Here we show that three polysaccharides derived from seaweed (carrageenans) with differing sulphation levels and patterns can inhibit the in vitro erythrocytic invasion and growth of both drug sensitive and drug resistant P. falciparum lines and the adhesion of parasitized erythrocytes to the human glycoprotein CD36.

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Section: Resultsmentioning

confidence: 99%

Carrageenans inhibit the in vitro growth of Plasmodium falciparum and cytoadhesion to CD36

et al. 2005

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“…Carrageenan is a selective inhibitor of several enveloped viruses, including such human pathogens as human immunodeficiency virus, herpes simplex virus (HSV), human cytomegalovirus, human rhinoviruses and others (Girond et al 1991;Marchetti et al 1995;Carlucci et al 1999;Caceres et al 2000;Zacharopoulos and Phillips 1997;Stiles et al 2008). Carrageenan acts primarily by preventing the binding or the entry of virions into cells (Buck et al 2006, Grassauer et al 2008).…”

Section: Antiviral Activitymentioning

confidence: 99%

Carrageenan: a review

Nečas¹,

2013

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Carrageenan is a natural carbohydrate (polysaccharide) obtained from edible red seaweeds. The name Carrageenan is derived from the Chondrus crispus species of seaweed known as Carrageen Moss or Irish Moss in England, and Carraigin in Ireland. Carraigin has been used in Ireland since 400 AD as a gelatin and as a home remedy to cure coughs and colds. It grows along the coasts of North America and Europe. Carrageenans are used in a variety of commercial applications as gelling, thickening, and stabilising agents, especially in food products and sauces. Aside from these functions, carrageenans are used in experimental medicine, pharmaceutical formulations, cosmetics, and industrial applications.Keywords: carrageenan; pharmacokinetics; toxicity; biological activity List of abbreviations 3,6-AG = 3,6, anhydro-galactose, 5-HT = 5-hydroxytryptamine, 6-APA = 6-amino penicillanic acid, ADI = acceptable daily intake, AG = amino guanidine, AIDS = acquired immune deficiency syndrome, AT-III = anti-thrombin-III, bw = body weight, COX-2 = cyclooxygenase-2, eNOS = endothelial nitric oxide synthase, FAO = food and agriculture organization, HC-II = heparin co-factor II, HIV = human immunodeficiency virus, HPV = human papilloma virus, HSV = herpes simplex virus, IFAC = international food additives council, iNOS = inducible nitric oxide synthase, JECFA = Joint FAO/WHO Expert Committee on Food Additives, L-NMMA = NG-monomethyl-l-arginine, nNOS = neuronal nitric oxide synthase, NO = nitric oxide, NOS = nitric oxide synthase, NSAIDs = non-steroidal antiinflammatory drugs, PGs = prostaglandins, SSL = sodium stearoyl lactylate, TNF-α = tumour necrosis factor-α

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“…They have also shown several potential pharmaceutical properties including antitumor, immunomodulatory (Zhou et al, 2004), antihyperlipidemic (Panlasigui, Baello, Dimatangal, & Dumelod, 2003) and anticoagulant activities (Caceres, Carlucci, Damonte, Matsuhiro, & Zuniga, 2000). Some in vitro studies suggest that carrageenans may also have antiviral properties, inhibiting the replication of herpes and hepatitis A viruses (Carlucci, Scolaro, & Damonte, 1999;Girond, Crance, Van Cuyck-Gandre, Renaudet, & Deloince, 1991;Gonzalez, Alarcon, & Carrasco, 1987;Marchetti et al, 1995).…”

Section: Biological Activitiesmentioning

confidence: 99%

Carrageenans: Biological properties, chemical modifications and structural analysis – A review

Campo

Kawano

Silva

et al. 2009

Carbohydrate Polymers

1,105

558

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Antiviral activity of carrageenan on hepatitis A virus replication in cell culture

Cited by 87 publications

References 24 publications

Carrageenans inhibit the in vitro growth of Plasmodium falciparum and cytoadhesion to CD36

Carrageenans inhibit the in vitro growth of Plasmodium falciparum and cytoadhesion to CD36

Carrageenan: a review

Carrageenans: Biological properties, chemical modifications and structural analysis – A review

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