Antiviral activity of Bolivian plant extracts

Abad, María J. F.; Bermejo, Paulina; Gonzales, Eduardo; Iglesias, I.; Irurzun, Alicia; Carrasco, Luís

doi:10.1016/s0306-3623(98)00214-6

Cited by 74 publications

(42 citation statements)

References 12 publications

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“…The genus Baccharis has more than 500 species widely distributed in Brazil, Colombia, Chile, Argentina and Mexico (Lorenzi & Matos, 2002). The phytochemistry of this genus has been studied since the beginning of the last century, and so far more than 150 compounds have been isolated and identified (Abad et al, 1999). Flavonoids and terpenoids, such as monoterpenes, sesquiterpenes, diterpenes and triterpenes, are the most frequent compounds (Moreira et al, 2003, Verdi et al, 2005.…”

Section: Baccharis Trimera (Less) DCmentioning

confidence: 99%

The Use of Brazilian Medicinal Plants to Combat Schistosoma mansoni

Allegretti¹,

Oliveira²,

Oliveira³

et al. 2012

Schistosomiasis

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Section: Baccharis Trimera (Less) DCmentioning

confidence: 99%

The Use of Brazilian Medicinal Plants to Combat Schistosoma mansoni

Allegretti¹,

Oliveira²,

Oliveira³

et al. 2012

Schistosomiasis

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“…Recently, antimicrobial (9,10), antiviral (11), antioxidant (12,13), antiproliferative (14), antiprotozoal (15), antifungal (16), anti-inflammatory, antinociceptive (17,18), antidiarrheal, and vasodilatory (19,20) activities have been reported from different species of Satureja. This plant is also used in ethnomedicine as an analgesic and antiseptic agent.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial, antioxidant, cytotoxic and apoptotic activities of Satureja khuzestanica

Soltanzadeh

Açık

Türk

et al. 2018

GMJ

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Objective: Natural products with antimicrobial effect are currently investigated in order to eliminate the use of synthetic antibiotics that cause the resistance of microorganisms. This study determines the antibacterial, antioxidant activity, and also the cytotoxic and apoptotic effect of Satureja khuzestanica on various cancer cell lines. Materials and methods: The individual constituents were identified by their identical retention indices referring to known compounds from the literature. Methanol and ethanol extracts of S. khuzestanica (25 and 50 mg/mL) were screened against four Gram-positive and four Gram-negative bacteria. The plant extracts were tested for their antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. The interaction between the extracts and plasmid DNA were analyzed by agarose gel electrophoresis. In addition, the cytotoxic activity of the extracts was evaluated on MCF-7, DLD-1, osteosarcoma, and fibroblast cell line. Finally, gene expression of caspase-3, Bax and Bcl-2 were investigated by real-time PCR. Results: Our result indicated that both extracts showed good inhibitory activity against both Gram-negative (Escherichia coli ATCC 35218) and positive (Bacillus subtilis ATCC 6633) bacteria. In addition, the methanol extract of S. khuzestanica had strong antioxidant activity (IC50=37.0±0.3 μg/mL). The extracts showed a strong effect on plasmid DNA. The methanol extract of S. khuzestanica showed a good concentration-dependent cytotoxicity. Finally, IC50=47.00a±1.21μg/mL, ethanol, and water extract had apoptotic effect in MCF-7 cell line. Discussion: MCF-7 was detected as the most sensitive cell line therefore further studies should be done on this plant extract as a potential anticancer agent against breast cancer.

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“…Though, specific antiviral treatments for herpesvirus infections are available (Elion et al, 1997), no such therapy is available for other viral infections including PPR. In the past few decades, as an alternative to conventional chemical agents, a large number of phytochemicals have been assessed for their potential antiviral activity (Kalvatchev et al, 1997;Yamasaki et al, 1998;Abad et al, 1999aAbad et al, ,b, 2000. Acacia arabica var.…”

Section: Introductionmentioning

confidence: 99%