Antiviral activity of a sulphated polysaccharide from the red seaweed nothogenia fastigiata

Damonte, Elsa B.; Neyts, Johan; Pujol, Carlos A.; Snoeck, Robert; Andrei, Gracíela; Ikeda, Satoru; Witvrouw, Myriam; Reymen, D.; Haines, H. H.; Matulewicz, Marı́a C.; Cerezo, Alberto S.; Coto, Celia E.; Clerco, Eric De

doi:10.1016/0006-2952(94)90254-2

Cited by 88 publications

(47 citation statements)

References 24 publications

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“…Therefore, it seems that the extracts from these brown seaweeds could exhibit higher antiviral effect on enveloped DNA virus than on RNA virus, and had no effect on RNA virus with segmented genome, e.g., the influenza virus. However, Damonte et al(1994) reported that the water extract of a red seaweed showed high inhibitory effect on RSV in HeLa cells and influenza A virus in MDCK cells with very low EC 50 values. These findings suggest that there are possible differences in the virus-inhibitory effects of the seaweed extract.…”

Section: Discussionmentioning

confidence: 99%

Antiviral activities of extracts from Hong Kong seaweeds

Wang

Ooi

Ang

2008

J. Zhejiang Univ. Sci. B

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Abstract:We extracted six Hong Kong brown seaweed species with hot water for their antiviral properties. The cytotoxicity and antiviral activity of these extracts were tested by MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenlytetrezolium bromide] method, cytopathic effect reduction assay, and plaque reduction assay. The antiviral effect was further determined by flow cytometric analysis. The results showed that most of these extracts inhibited the propagation of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) standard strains with very low cytotoxicity to the host cells. The extracts of Hydroclathrus clathratus and Lobophora variegata showed more potential anti-HSV activities than the extracts of the other four seaweeds. They also had moderate antirespiratory syncytial virus (RSV) activities but could not inhibit influenza A virus. Hydroclathrus clathratus was further extracted by diluted acid and alkali and the antiviral effects of the extracts were also detected. The result showed that the hot water extract contained the main carbohydrate components that exhibited the antiviral activities against various strains of HSV, including the acyclovir-resistant strain. HI-3, a compound fractionated from this hot water extract, showed a dose-dependent anti-HSV activity in flow cytometric analysis and plaque reduction assay.

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Section: Discussionmentioning

confidence: 99%

Antiviral activities of extracts from Hong Kong seaweeds

Wang

Ooi

Ang

2008

J. Zhejiang Univ. Sci. B

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“…In vivo anti-inflammatory effect of a sulfated polysaccharide isolated from the marine brown algae Lobophora variegata most studied, but sulfated polysaccharides are known to modulate a large number of other activities, such as antiviral (Damonte et al, 1994), antitumor (Lins et al, 2009), antiatherosclerotic (Engelberg, 1991), antioxidant (Zhang et al, 2003) and antinociceptive (Assreuy et al, 2008).…”

Section: Research Articlementioning

confidence: 99%

In vivoanti-inflammatory effect of a sulfated polysaccharide isolated from the marine brown algaeLobophora variegata

Siqueira

Silva

Alencar

et al. 2010

Pharmaceutical Biology

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“…(1990bSchols et el. ( , 1992, Witvrouw et al (1991Witvrouw et al ( , 1992Witvrouw et al ( , 1994 and Damonte et al (1994). :"…”

Section: Inhibition Of Syncytium Formationunclassified

Antiviral Portrait Series: 4. Polysuifates as Inhibitors of HIV and Other Enveloped Viruses

Witvrouw¹,

Desmyter²,

Clercq

1994

Antivir Chem Chemother

Self Cite

101

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Polysulfates are highly potent and selective inhibitors of the in vitro replication of HIV and other enveloped viruses. They not only inhibit the cytopathic effect of HIV, but also prevent HIV-induced syncytium (giant cell) formation. They also act synergistically with other anti-HIV drugs. The anti-HIV activity of polysulfates is a result of their shielding of the positively charged sites in the V3 loop of the viral envelope glycoprotein gp120. When polysulfates were administered intravenously to rabbits, their half-life was approximately 2h. Although they are very poorly absorbed following oral administration, they can be made orally bioavailable with the appropriate chemical modifications. Also, polysulfates may lose (much of) their anticoagulant activity upon chemical modification without giving up their anti-HIV activity. Their efficacy in the therapy and/or prophylaxis of retroviral infections remains to be demonstrated both in animal models and in humans.

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Antiviral activity of a sulphated polysaccharide from the red seaweed nothogenia fastigiata

Cited by 88 publications

References 24 publications

Antiviral activities of extracts from Hong Kong seaweeds

Antiviral activities of extracts from Hong Kong seaweeds

In vivoanti-inflammatory effect of a sulfated polysaccharide isolated from the marine brown algaeLobophora variegata

Antiviral Portrait Series: 4. Polysuifates as Inhibitors of HIV and Other Enveloped Viruses

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