Antiviral activity in vitro of two preparations of the herbal medicinal product Sinupret® against viruses causing respiratory infections

Abstract

Sinupret(®), a herbal medicinal product made from Gentian root, Primula flower, Elder flower, Sorrel herb, and Verbena herb is frequently used in the treatment of acute and chronic rhinosinusitis and respiratory viral infections such as common cold. To date little is known about its potential antiviral activity. Therefore experiments have been performed to measure the antiviral activity of Sinupret(®) oral drops (hereinafter referred to as "oral drops") and Sinupret(®) dry extract (hereinafter referred to as "dry extract"), in vitro against a broad panel of both enveloped and non-enveloped human pathogenic RNA and DNA viruses known to cause infections of the upper respiratory tract: influenza A, Chile 1/83 (H1N1) virus (FluA), Porcine Influenza A/California/07/2009 (H1N1) virus (pFluA), parainfluenza type 3 virus (Para 3), respiratory syncytial virus, strain Long (RSV), human rhinovirus B subtype 14 (HRV 14), coxsackievirus subtype A9 (CA9), and adenovirus C subtype 5 (Adeno 5). Concentration-dependent antiviral activity (EC(50) between 13.8 and 124.8 μg/ml) of Sinupret(®) was observed against RNA as well as DNA viruses independent of a viral envelope. Remarkable antiviral activity was shown against Adeno 5, HRV 14 and RSV in which dry extract was significantly superior to oral drops. This could be ascertained with different assays as plaque-reduction assays in plaque forming units (PFU), the analyses of a cytopathogenic effect (CPE) and with enzyme immunoassays (ELISA) to determine the amount of newly synthesised virus. Our results demonstrate that Sinupret(®) shows a broad spectrum of antiviral activity in vitro against viruses commonly known to cause respiratory infections.

Phytotherapy in acute bronchitis: what is the evidence?

“…In contrast, in a myriad of in vitro and ex vitro studies, important effects on several components of the pathophysiology by single and composite herbal extracts are published, e.g., [35][36][37][38][39][40][41][42][43][44]. It is beyond the scope of this article to discuss their results.…”

Efficacy and safety of combined treatment of acute rhinosinusitis by herbal medicinal product Sinupret and mometasone furoate nasal spray

“…[15] Also, Sinupret has antiviral effect against adenoviruses, human rhinoviruses, respiratory syncytial virus, coxsackievirus, influenza and parainfluenza virus. [9] The mechanism of this action is inhibition of neuraminidase, an important enzyme for process of viral replication. [9] Sinupret has bactericidal effects on Gram-positive and Gram-negative bacteria, but this medication is not effective against Escherichia coli.…”

“…[9] The mechanism of this action is inhibition of neuraminidase, an important enzyme for process of viral replication. [9] Sinupret has bactericidal effects on Gram-positive and Gram-negative bacteria, but this medication is not effective against Escherichia coli.…”

“…Previous investigations clearly demonstrated mucolytic, secretomotoric, anti-inflammatory, antiviral and antibacterial effects of this medicinal product. [7][8][9][10] These characteristics, as well as the results of two double-blind, placebo-controlled studies recommended the use of Sinupret as a good treatment option in both ARS and chronic rhinosinusitis (CRS). [11,12] The aim of our study was to evaluate the efficacy and safety of combined mometasone furoate nasal spray (MFNS) and oral Sinupret therapy in comparison to MFNS monotherapy when treating mild to moderate ARS.…”

New View on Cough Treatment in Children

“…It was created using a special manufacturing technology -phytoneering, which allows reaching the maximal concentration of active materials at minimal allergenicity, good tolerability and high safety profile. The fivecomponent composition allows the phytogenic drug to have secretolytic, anti-inflammatory, antiviral and immunomodulating action, which has been proven by clinical trials [11][12][13][14]. Sinupret effectively regulates secretion and normalizes mucus viscosity, eliminates mucostasis and recovers mucociliary clearance.…”