Antiveratrinic Activity of Lactones and Peroxides**School of Pharmacy, University of Kansas, Lawrence, Kan

Mentha x piperita shoot tips and first leaf pairs were fed with aqueous solutions of different deuterium-labeled pulegone and various enantiomeric distributions. The essential oil was extracted by solid-phase microextraction and analyzed using enantioselective multidimensional gas chromatography/mass spectrometry. The genuine p-menthan-3-ones (-)-menthone and (+)-isomenthone as well as their labeled analogues were analyzed simultaneously. Both enantiomers of labeled pulegone were converted into the corresponding labeled p-menthan-3-ones by Mentha x piperita, indicating an unspecific reduction process. The generation of 4S- and 4R-configured p-menthan-3-ones differed in their stereoselectivities. Labeled (S)-pulegone was reduced by Mentha x piperita more rapidly rather than (R)-pulegone. From a comparison of labeled pulegone enantiomers the bioconversion preferrably led to 4S-configured diastereomers.

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Antiveratrinic Activity of Lactones and Peroxides**School of Pharmacy, University of Kansas, Lawrence, Kan

Cited by 4 publications

References 2 publications

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The Veratrum Alkaloids

Biogenetic Studies inMentha×piperita. 2. Stereoselectivity in the Bioconversion of Pulegone into Menthone and Isomenthone

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