Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae)

Linh, Hoang Thi; Chabot, Guy G.; Grellier, Philippe; Quentin, Lionel; Dumontet, Vincent; Poulain, Cyril; Espindola, Laïla Salmen; Michel, Sylvie; Vo, Hue T.B.; Deguin, Brigitte; Grougnet, Raphaë͏l

doi:10.1016/j.ejmech.2015.01.012

Cited by 34 publications

(16 citation statements)

References 43 publications

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“…Locomotor effect tests confirmed the assumption that the antidepressant-like effect of cocoa polyphenolic extract is specific after subchronic treatment in the FST model. 6 Byrsonima crassifolia (Malpighiaceae) has been used in traditional medicine to treat some mental-related diseases. Herrera-Ruiz et al [56] reported that the methanolic extract of Byrsonima crassifolia significantly decreased the immobility time at a dose of 500 mg/kg in the FST of mice and displayed a significant antidepressant-like effect (P < 0. effect of the ZQ aqueous extract was evaluated by the FST and TST and the immobility time of the mice were significantly shortened.…”

Section: Extracted Flavonoidsmentioning

confidence: 99%

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Antidepressant-like effects and mechanisms of flavonoids and related analogues

Guan

Liu

2016

European Journal of Medicinal Chemistry

107

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Flavonoids, possessing a basic phenylbenzopyrone core, are important components of the human diet, and are found in many medicinal plants. Flavonoids include chalcones, flavanones and their derivatives. Synthetic and natural isolated flavonoids display an enormous number of biological activities such as antitumor, antiplatelet, anti-malarial, anti-inflammatory, antidepressant and anticonvulsant properties. This review article focuses on the antidepressant-like effect, structure-activity relationship and mechanism of action of total flavonoid extracts isolation from natural sources, flavonoid compounds and their related analogues.

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Section: Extracted Flavonoidsmentioning

confidence: 99%

“…Flavonoids are phytochemicals found in a variety of fruits and vegetables and confer color, flavor, and aroma, as well as nutritional and health benefits [2][3][4]. Many flavonoids possess antioxidant, anti-inflammatory and antidepressant activity in animal studies [5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Antidepressant-like effects and mechanisms of flavonoids and related analogues

Guan

Liu

2016

European Journal of Medicinal Chemistry

107

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“…Moreover, in many depressed patients, the impairment of the function of the HPA axis was noticed [ 71 ]. It has been reported that many flavonoids possess antioxidant, anti-inflammatory, and antidepressant activities in animal studies [ 72 , 73 ].…”

Section: Resultsmentioning

confidence: 99%

Antidepressant Flavonoids and Their Relationship with Oxidative Stress

Hrițcu

Ionita

Postu

et al. 2017

Oxidative Medicine and Cellular Longevity

101

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Depression is a serious disorder that affects hundreds of millions of people around the world and causes poor quality of life, problem behaviors, and limitations in activities of daily living. Therefore, the search for new therapeutic options is of high interest and growth. Research on the relationship between depression and oxidative stress has shown important biochemical aspects in the development of this disease. Flavonoids are a class of natural products that exhibit several pharmacological properties, including antidepressant-like activity, and affects various physiological and biochemical functions in the body. Studies show the clinical potential of antioxidant flavonoids in treating depressive disorders and strongly suggest that these natural products are interesting prototype compounds in the study of new antidepressant drugs. So, this review will summarize the chemical and pharmacological perspectives related to the discovery of flavonoids with antidepressant activity. The mechanisms of action of these compounds are also discussed, including their actions on oxidative stress relating to depression.

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“…The phytochemical analyses of the investigated plant extracts showed the presence of triterpenes, flavonoids, tannins, and carbohydrates; the S. saponaria extract also contained saponins (Table 3). Several studies have reported on the trypanocidal activity of natural flavonoids (Takeara et al, 2003;Sulsen et al, 2007;Mai et al, 2015). The lyophilized aqueous extract from Lychnophora pinaster Mart (Asteraceae) exhibits trypanocidal action (113.62 μg/mL); chemical characterization of this extract by HPLC revealed the presence of caffeic acid, isochlorogenic acid, vitexin, isovitexin, and quercetin (Silveira et al, 2005).…”

Section: Resultsmentioning

confidence: 99%