Antiulcerogenic Activities of the Extracts and Isolated Flavonoids of <i>Euphorbia cuneata</i> Vahl

Awaad, Amani S.; Al-Jaber, Nabilah A.; Moses, John E.; El‐Meligy, Reham M.; Zain, Mohamed E.

doi:10.1002/ptr.4872

Cited by 31 publications

(32 citation statements)

References 17 publications

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“…4) isolated from Euphorbia cuneata, a folk medicine used for the treatment of gastric disorders, demonstrated antiulcerogenic action. 43) These results confirm the potential value of flavonoids from TMPs, both in …”

Section: Flavonoidssupporting

confidence: 76%

“…5) with a rhamnoglucosyl moiety at C-3 exhibited much higher activity. 65) It is not surprising that SAR studies provide information (41)(42)(43)(44) showed that a prenyl group at C-4 plays an important role in the inhibitory activity. SAR studies on a new nitrocontaining tetrahydroprotoberberine (45) and five isoquinoline alkaloids (46)(47)(48)(49)(50) showed that nitro substituents at ring A improve anti-AchE activity.…”

Section: Sar Studies On the Pharmacological Activity Ofmentioning

confidence: 99%

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Prospecting for Bioactive Constituents from Traditional Medicinal Plants through Ethnobotanical Approaches

Wang

Long

et al. 2014

Biological & Pharmaceutical Bulletin

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Pharmacologically active constituents from traditional medicinal plants have received great attention as sources of novel agents, pharmaceutical intermediates, and chemical entities for synthetic or semisynthetic drugs due to their potent pharmacological activities, low toxicity, and economic viability. Numerous components have been isolated from traditional medicinal plants, including alkaloids, flavonoids, and terpenoids, and clinical and experimental studies suggested that these components have useful pharmacological properties such as antiinfectious, antioxidative, and antiinflammatory effects. In this review, modern ethnobotanical approaches to explore folk medicinal plants as candidates for drug discovery with the greatest possibility of success are discussed. Determining the bioactive mechanisms and tracing structure-activity relationships will promote the discovery of new drugs and pharmacological agents.

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Section: Flavonoidssupporting

confidence: 76%

Section: Sar Studies On the Pharmacological Activity Ofmentioning

confidence: 99%

Prospecting for Bioactive Constituents from Traditional Medicinal Plants through Ethnobotanical Approaches

Wang

Long

et al. 2014

Biological & Pharmaceutical Bulletin

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“… Preparation of fungal extract : ▪ For in‐vitro studies : Stock solutions of the total extracts and compounds were prepared at a concentration of 20 mg/mL in DMSO (Sigma, UK) and diluted to appropriate concentrations prior to assays. ▪ For in‐vivo studies : The methanol extracts of each investigated fungi and isolated compounds were freshly prepared by suspension in sterile normal saline with the aid of few drops of tween 80)Djalma dos Santos et al ., ) Acute toxicity (LD 50 ) test :An acute toxicity test was carried out for the alcohol extracts of D. rostrata and E. tonpholium according to Turner, (1965). Groups of mice, each of six, were used for testing doses up to 5000 mg/kg (Soliman et al ., ; Awaad et al ., ). Sub‐chronic toxicity :…”

Section: Methodsmentioning

confidence: 99%

Anti-leishmanial Activities of Extracts and Isolated Compounds fromDrechslera rostrataandEurotium tonpholium

et al. 2013

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The fungal extract of Drechslera rostrata and Eurotium tonpholium showed a significant anti-leishmanial activity against Leishmania major; IC50 was 28.8 and 28.2 μg/mL, respectively. Seven compounds, five from D. rostrata (H1-H5) and two from E. tonpholium (H6 and H7), were isolated and identified using different spectroscopic analysis including (1) HNMR, (13) CNMR, Hetero-nuclear multiple bond connectivity (HMBC), Hetero-nuclear Multiple Quantum Correlation (HMQC), and EI-MS. The isolated compounds are: di-2-ethylhexyl phthalate (1), (22E)-5α,8α-epidioxyergosta-6,22-diene-3β-ol (2),1,3,8-trihydroxy-6-methyl-nthraquinone (3), aloe-emodine 8-O-glucopyranoside(4), 2R, 3R,4R,5R hexane 1, 2, 3, 4, 5, 6 hexole (Mannitol) (5), 1,8-dihydroxy-3-methoxy-6-methyl-anthraquinone (6) and 1, 4, 5-trihydroxy-7-methoxy-2-methyl-anthraquinone (7). However, compounds (1) and (6) showed activity against L. major with IC50 of 3.2 and 10.38 µg/mL, respectively. On the other hand, oral administration of the two extracts (100 mg/kg) and compounds 1 and 6 (50 mg/kg) showed very good activity when compared with the anti-leishmanial drug Pentostam (125 mg/kg). Interestingly, the complete heeling activity of the extracts and compounds (1) and (6) was obtained after 13-17 days of treatment, while complete healing activity of Pentostam was obtained after 28 days. No alteration on liver and kidney functions was recorded on animals treated with the two extracts for 15 consecutive days.

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“…For instance, orally given aqueous extract of date fruit induced a 40% inhibition of ulcer index while ethanol extract caused a 55% inhibition in ethanol-induced gastric ulcer (Al-Qarawi et al, 2005). Likewise, 125mg of euphorbia cuneata Vahl.-extracted with chloroform or ethanol only induced a 30% inhibition while the same dose of ethyl acetate extract induced 58% inhibition in ulcerogenesis in an ethanol-induced gastric ulcer model (Awaad et al, 2013). Melanchauski et al (2013) reported that 100mg/kg of the methanolic extract of Ailanthus excels bark caused 56% inhibition of ulcerogenesis while the same dose of diethyl ether extract induced 83% inhibition, which was the same efficacy as conventional antiulcer agent, such as carbenoxolone.…”

Section: Efficacymentioning

confidence: 99%

Antiulcerogenic benefits of herbal ingredients in ethanol-induced animal models

Bi¹,

Man²,

Hu³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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Background: Gastric ulcer is a common disorder in digestive system. Alcohol consumption is one of the key risk factor in the pathogenesis of gastric ulcer. Although therapeutic approaches are widely available, preventive regimens are limited. Numerous studies have demonstrated that herbal medicines display preventive benefit in the development of ethanol-induced gastric ulcers in both rat and mouse models. The preventive efficacy of herbal medicines on the development of ethanol-induced gastric ulcers is comparable or superior to histamine receptor 2 antagonists. But herbal medicines have fewer side effects. Materials and Methods: Keywords including gastric ulcer, herbal medicines, prevention and natural ingredients were used to search on http://www.ncbi.nlm.nih.gov/pubmed. The search was performed on January 12, 2014. Only articles published in English were used in this review. Result and Conclusion: According to the mechanisms of their action and pathogenesis of gastric ulcer, combination of certain herbal medicines could be a valuable alternative to prevent the development of gastric ulcer, particularly for the subjects who are at a higher risk of developing gastric ulcer.

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Antiulcerogenic Activities of the Extracts and Isolated Flavonoids of Euphorbia cuneata Vahl

Cited by 31 publications

References 17 publications

Prospecting for Bioactive Constituents from Traditional Medicinal Plants through Ethnobotanical Approaches

Prospecting for Bioactive Constituents from Traditional Medicinal Plants through Ethnobotanical Approaches

Anti-leishmanial Activities of Extracts and Isolated Compounds fromDrechslera rostrataandEurotium tonpholium

Antiulcerogenic benefits of herbal ingredients in ethanol-induced animal models

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