Antiulcer mechanisms of Vernonia condensata Baker: A medicinal plant used in the treatment of gastritis and gastric ulcer

Boeing, Thaise; Silva, Luísa Mota da; Somensi, Líncon Bordignon; Cury, Benhur Judah; Costa, Ana Paula Michels; Petreanu, Marcel; Niero, Rivaldo; Andrade, Sérgio Faloni de

doi:10.1016/j.jep.2016.02.049

Cited by 45 publications

(20 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Protein concentrations were determined by the Bradford method (Bio‐Rad, Hercules, CA, USA). For a detailed protocol of these measurements, see Boeing et al ().…”

Section: Methodsmentioning

confidence: 99%

Luteolin prevents irinotecan‐induced intestinal mucositis in mice through antioxidant and anti‐inflammatory properties

Boeing

Souza

Speca

et al. 2020

British J Pharmacology

Self Cite

View full text Add to dashboard Cite

Background and Purpose: Intestinal mucositis refers to mucosal damage caused by cancer treatment, and irinotecan is one of the agents most associated with this condition. Focusing on the development of alternatives to prevent this important adverse effect, we evaluated the activity of the flavonoid luteolin, which has never been tested for this purpose despite its biological potential. Experimental Approach: The effects of luteolin were examined on irinotecaninduced intestinal mucositis in mice. Clinical signs were evaluated. Moreover, histological, oxidative, and inflammatory parameters were analysed, as well as the possible interference of luteolin in the anti-tumour activity of irinotecan. Key Results: Luteolin (30 mgÁkg −1 ; p.o. or i.p.) prevented irinotecan-induced intestinal damage by reducing weight loss and diarrhoea score and attenuating the shortening of the duodenum and colon. Histological analysis confirmed that luteolin (p.o.)prevented villous shortening, vacuolization, and apoptosis of cells and preserved mucin production in the duodenum and colon. Moreover, luteolin treatment mitigated irinotecan-induced oxidative stress, by reducing the levels of ROS and LOOH and augmenting endogenous antioxidants, and inflammation by decreasing MPO enzymic activity, TNF, IL-1β, and IL-6 levels and increasing IL-4 and IL-10. Disruption of the tight junctions ZO-1 and occludin was also prevented by luteolin treatment.Importantly, luteolin did not interfere with the anti-tumour activity of irinotecan. Conclusion and Implications: Luteolin prevents intestinal mucositis induced byirinotecan and therefore could be a potential adjunct in anti-tumour therapy to control this adverse effect, increasing treatment adherence and consequently the chances of cancer remission.

show abstract

“…Protein concentrations were determined by the Bradford method (Bio‐Rad, Hercules, CA, USA). For a detailed protocol of these measurements, see Boeing et al ().…”

Section: Methodsmentioning

confidence: 99%

Luteolin prevents irinotecan‐induced intestinal mucositis in mice through antioxidant and anti‐inflammatory properties

Boeing

Souza

Speca

et al. 2020

British J Pharmacology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Nowadays, the treatment of gastric ulcer is based on the reduction of the acid gastric secretion, through of the use of proton pump inhibitors (PPIs) (such as omeprazole) and histamine H2‐receptor antagonists (such as cimetidine); gastric acid neutralization through antacids drugs and, when necessary, antibiotics were employed to the Helicobacter pylori eradication . Those therapeutic options are effective; however, when the patients remain under daily stress, poor diet, alcohol abuse and nonsteroidal anti‐inflammatory drugs consumption, smoking habit, and persistent infection by H. pylori , the ulcer recurrence is very frequent . Therefore, to avoid this problem, many patients use antisecretory drugs continuously, mainly PPIs, which lead to the side effects related to these drugs, including neoplastic lesions , osteoporosis , or increased risk of dementia .…”

Section: Introductionmentioning

confidence: 99%

Hydroalcoholic extract from Baccharis dracunculifolia recovers the gastric ulcerated tissue, and p‐coumaric acid is a pivotal bioactive compound to this action

et al. 2019

Self Cite

View full text Add to dashboard Cite

Baccharis dracunculifolia is a medicinal plant native to southeastern Brazil and is the main botanical source used by bees (Apis mellifera) in the manufacture of green propolis and display similar gastroprotective action and chemical profile. This article reports the healing gastric ulcer activity of the hydroethanolic extract of B. dracunculifolia (HEBD) in an acetic acid-induced ulcer model. In addition to the extract, the isolated compounds ferulic acid, p-coumaric acid, caffeic acid, baccharin, and aromadendrin-4'-O-methyl ether were also assayed. HEBD at a dose of 300 mg/kg reduced the ulcerated area by 49.4% after treatment for 7 days, twice a day. Histological analyses revealed that the margins and base of the ulcer obtained significant regeneration, and periodic acid Schiff base staining showed a 78.2% increase in the mucin levels. The action on the enzymatic antioxidant system demonstrated an increased activity of superoxide dismutase and glutathione-S-transferase, in addition to raising glutathione reduced levels and myeloperoxidase activity. HEBD did not show cytotoxicity in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylterazole bromine test. In vitro, HEBD inhibited the H + /K + -ATPase enzyme and showed antioxidant activity in the 2,2 diphenyl-1-picryllydrazyl test. Regarding the isolated compounds, oral administration of p-coumaric acid (15 mg/kg) reduced the ulcerated area by 66.2%. The results suggest that HEBD recovers the gastric ulcerated tissue, raising mucus and antioxidant enzyme levels, and reducing the H + /K + -ATPase activity. In addition, the findings confirm that p-coumaric acid is a pivotal bioactive compound on the gastric healing effects elicited by HEBD. © 2019 BioFactors, 45(3):479-489, 2019

show abstract

“…Vernonia condensata Baker, popularly known in Brazil as "alumã", "figatil" or "necroton", is a medicinal plant belonging to the family Asteraceae, widely distributed in the country, traditionally used in folk medicine for its analgesic, anti-inflammatory, anti-fever, antibacterial and antiulcerogenic properties (Boeing et al, 2016;Thomas et al, 2016;Sharifi-Rad et al, 2018;Silva et al, 2018). Besides this, some secondary metabolites such as saponins, tannins, alkaloids, phenolic compounds and flavonoids have been detected in extracts of V. condensata (Risso;Scarminio;Moreira, 2010).…”

Section: Introductionmentioning

confidence: 99%

In vitro callus induction and development of Vernonia condensata Baker with embryogenic potential

Rodrigues

Almeida²,

Lêdo

et al. 2020

Ciênc. agrotec.

View full text Add to dashboard Cite

Vernonia condensata Baker has been traditionally used in folk medicine for the treatment of several inflammatory and infectious processes. Overexploitation of this plant species has drastically reduced its population in its natural habitat (Cerrado). Therefore, tissue culture tools, such as somatic embryogenesis, can be used as an alternative method for rapid and large-scale plant regeneration. The objectives of this study were to induce callogenesis in Vernonia condensata from different types of explants and to evaluate the structural aspects of the development of pro-embryogenic masses of this species by means of histological analyses. The formation of calli was induced from leaf explants and internodal segments, which were inoculated in EME medium supplemented with 50 g L-1 sucrose, 0.5 g L-1 malt extract and 2.68 μM NAA, plus varying concentrations of BAP (0.00, 2.22, 4.44 or 8.88 μM). After 40 days, the following morphogenetic traits were evaluated: intensity of callus formation, intensity of oxidation, callus texture, and morphogenesis. The calli with embryogenic masses were analyzed by light and scanning electron microscopy. Both types of explants were responsive regarding callogenesis, with the BAP concentration of 4.44 μM promoting the formation of friable calli associated with a larger percentage of calli with embryogenic masses. Cells from leaf explants and internodal segments were able to dedifferentiate and change into embryonic structures.

show abstract

Antiulcer mechanisms of Vernonia condensata Baker: A medicinal plant used in the treatment of gastritis and gastric ulcer

Cited by 45 publications

References 39 publications

Luteolin prevents irinotecan‐induced intestinal mucositis in mice through antioxidant and anti‐inflammatory properties

Luteolin prevents irinotecan‐induced intestinal mucositis in mice through antioxidant and anti‐inflammatory properties

Hydroalcoholic extract from Baccharis dracunculifolia recovers the gastric ulcerated tissue, and p‐coumaric acid is a pivotal bioactive compound to this action

In vitro callus induction and development of Vernonia condensata Baker with embryogenic potential

Contact Info

Product

Resources

About