Antiulcer Effect of Honey in Nonsteroidal Anti‐Inflammatory Drugs Induced Gastric Ulcer Model in Rats: A Systematic Review

Abstract

Background Peptic ulcer is a basic term for ulcers on the lower oesophagus, stomach, or jejunum. The specific term for ulcer in the stomach is gastric ulcer. The extensive use of honey around the globe helps researchers to study the usefulness of honey. Many studies had already been conducted and proved the effectiveness of honey in treating gastric ulcer. Methods A systematic review of the literature was conducted to identify relevant studies on honey used as an alternative treatment of gastric ulcer cause by NSAIDs. A comprehensive search was conducted in Medline, SCOPUS, and Ebscohost. The main criteria used were articles published in English and using NSAIDs-induced gastric ulcer in rat's model and those reporting the effectiveness of honey. Results Articles published between 2001 and 2014 were identified to be relevant in studies related to the inclusion criteria. The literature search found 30 potential and closely related articles in this review, but only 5 articles were taken which meet the criteria needed to be fulfilled. Conclusions All studies in this review reported the efficacy of honey for gastric ulcer based on its antioxidant and cytoprotective activities. Most of the studies conducted used different types of honey at various doses on rats. Future studies should be conducted to identify the appropriate dose for humans to achieve similar gastroprotective effects.

<p>Pumpkin Oil–Based Nanostructured Lipid Carrier System for Antiulcer Effect in NSAID-Induced Gastric Ulcer Model in Rats</p>

“…Nonetheless, the most commonly affected organs are the lesser curvature in the stomach and proximal duodenum, however, ulceration may also occur anywhere in the gastrointestinal tract (GIT) from pylorus to cardia. 2,3 Importantly, the prolonged use of NSAIDs is the second most common cause of PUD. 4 NSAIDs used for anti-inflammatory, antipyretic, pain-relief, anti-platelet aggregation, and anti-thrombogenesis indications.…”

“…5 In particular, Indomethacin, an member of NSAIDs family, is widely used for the management of rheumatoid arthritis, several inflammatory diseases, and for its well-established cardiovascular protection properties; however, its contribution to gastric ulceration has been documented in literature. 2 The induced inhibition of the cyclooxygenase enzyme (COX-2) enzyme is responsible for indomethacin's anti-inflammatory effect. Nevertheless, when used to alleviate inflammation and pain, it is known to exert a severe damaging effect on epithelial cells of the digestive tract, which constitutes its serious side effect.…”

A Scoping Review of the Evidence for the Medicinal Use of Natural Honey in Animals

“…The systematic review identified by our scoping study was a biomedical research study from Malaysia, published in 2018. The aim was to “evaluate the therapeutic potential of honey in the context of its gastroprotective function against (non-steroidal anti-inflammatory drug)-induced gastric ulcers” in rats ( 24 ). Non-rat animal models were ineligible for this review, and the comparator group was required to be exposed to non-steroidal anti-inflammatory drugs.…”

Protective effects of aqueous extracts of some honeys against HCl/ethanol‐induced gastric ulceration in rats

“…It could have preferred to achieve the truest result with more animal groups, but the rule of Three Rs (Replacement, Reduction, and Refinement) emphasized in The Principles of Humane Experimental Techniques was the genuine indicator in this study (Kirk, ). Therefore, inspired by literature, only two different concentrations of each honey sample were used for the applying of animal experiments (Almasaudi et al, ; Fazalda, Quraisiah, & Nur Azlina, ; Nasuti, Gabbianelli, Falcioni, & Cantalamessa, ). It was well‐known that the goal of reduction was to reduce the numbers of animals used to obtain information about a given amount and precision.…”