Antiulcer and gastric antisecretory effects of landolphia owariensis extracts in rats

Abstract

Summary:Water, Methanol and Chloroform Extracts of Landolphia owarensis were investigated for their effects on gastric acid secretion and ulceration in male albino rats. Two models of gastric lesion induced in experimental Wistar rats-HC1/ethanol-induced gastric lesions and Pylorus ligation-induced gastric lesions -were employed. In both models, the antiulcer activity of LA was compared with that of cimetidine (100 mg kg p.o.). In the HCl/Ethanol model, ulcer index and mucus production was determined. In pylorus ligated rat, ulcer index, mucus production, total volume of gastric juice and gastric acidity level were measured. Pre-treatment of animals with the aqueous extracts (100mg/kg and 200mg/kg) orally once daily for two weeks significantly reduced formation of ulcers induced by HCl/ethanol mixture, the percentage inhibition being 43.8% and 55.27% respectively. The Chloroform extract afforded the least protection with 23.07% and 14.77% inhibition. This was also accompanied by significant increases in gastric mucus production. In pylorus ligated rats, total volume of gastric juice and gastric acidity was significantly decreased as compared to control group, to levels comparable to that produced by cimetidine. The results indicate that the leaf extracts of LO contains antiulcer principles.

Anti-Ulcerogenic and Gastric Antisecretory Effects ofCorchorus olitoriusExtract in Male Albino Rats

“…The high in-vitro pepsinbinding activities of the extract may suggest a possible in-vivo binding to substrate proteins by a non-specific hydrophobic interaction to form complexes that are less vulnerable to peptic hydrolysis (15). The results are in agreement with earlier reports of antiulcer and gastric anti-secretory effects of extracts from Landolphia owariensis (15), Nelsonia canescence (16), and Eruka sativa (3).…”

Fatty Acid Profile and Physicochemical Properties of <i>Landolphia owariensis</i> P. Beauv Stringy Seed Oil

“…Its other medicinal and nutritional uses have as well been confirmed [2,5,[15][16][17]. Akubugwo and Ugbogu reported the physicochemical properties of Landolphia owariensis seed oil [18].…”

Antiulcer Effect of Honey in Nonsteroidal Anti‐Inflammatory Drugs Induced Gastric Ulcer Model in Rats: A Systematic Review

“…In study [ 27 ], induction to ulcer using aspirin is combined with ethanol. Omeprazole [ 27 , 30 ], sucralfate [ 26 , 31 , 32 ], mannitol [ 28 , 33 ], and cimetidine [ 29 , 34 , 35 ] have been used in these studies as referral drugs as well as some comparative substances to the efficacy of honey or comparative substances used in the experiments. Different doses used depend on the duration of the experiment and the weight of the rats.…”