Antiulcer activity of Utleria salicifolia rhizome extract

Rao, Ch. V.; Ojha, Sanjay Kumar; Radhakrishnan, Kadakkal; Govindarajan, R.; Rastogi, Subha; Mehrotra, Shanta; Pushpangadan, P.

doi:10.1016/j.jep.2003.12.020

Cited by 91 publications

(35 citation statements)

References 25 publications

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“…In brief, ELE might decrease lipid peroxidation by quenching free radicals in the gastric mucosa of pylorus-ligated rats and thus exhibit antiulcer activity. Several plant extracts have been shown to decrease the increase in LPO and SOD accompanied by an increase in CAT in various models of ulcer induced in rats, and their antiulcer activities were attributed to free radical scavenging and antioxidant properties (Sairam et al, 2003;Rao et al, 2004). Our present results are in agreement with these reports.…”

Section: Discussionsupporting

confidence: 93%

“…Several plant extracts have been shown to increase hexosamine and hexose accompanied by a reduction in the concentration of sialic acid and fucose followed by an increase in the C:P ratio in pylorus-ligated or gastric ulcer-induced rats (Pillai & Santakumari, 1984;Anoop & Jegadeesan, 2003;Shah et al, 2003;Rao et al, 2004), and it is reported that these extracts exhibit antiulcer activity by protection of the mucosal barrier system leading to more production of mucus, resulting in less degree of ulceration. It is postulated that the higher is the mucus production, the higher will be the mucin content and the lower will be the free acidity (Anoop & Jegadeesan, 2003).…”

Section: Discussionmentioning

confidence: 99%

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Antiulcer activity of ethanol leaf extract ofCassia fistula

Karthikeyan

Gobianand

2010

Pharmaceutical Biology

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Antiulcer activity of ethanol leaf extract ofCassia fistula

Karthikeyan

Gobianand

2010

Pharmaceutical Biology

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“…Therefore, the main therapeutic target is the control of this secretion using antacids, H2 receptor blockers (ranitidine, famotidine) or proton pump blockers (omeprazole and lansoprazole) (Rao et al, 2004). However, nowadays, gastric ulcer therapy faces a major drawback because most of the drugs currently available in the market show limited efficacy against gastric diseases and are often associated with severe side effects (Bandyopadhyay et al, 2002;Lehne, 1998).…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective effects of essential oil from Protium heptaphyllum on experimental gastric ulcer models in rats

Araujo¹,

Takayama²,

de-Faria³

et al. 2011

Rev. bras. farmacogn.

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Peptic ulcers are a common disorder of the entire gastrointestinal tract, its etiology has not been completely elucidated. The basic physiopathological of peptic ulcers result from an imbalance between some endogenous aggressive factor and cytoprotective factors. The treatment of this disease is usually done with antacids or proton pump, but are currently being used plants derivated compounds. We evaluated the gastroprotective properties and its possible mechanisms of action of the essential oil from Protium heptaphyllum (Aubl.) Marchand, Burseraceae (BB). The formation of ulcers, were evaluated in three experimental models, through the induction of gastric lesions by ethanol, nonsteroidal anti-infl ammatory drugs and acetic acid. The mechanisms of action were evaluated through the pylorus ligature experiment, western blot, GSH, GR, SOD, GPx, MDA and MPO activities. BB signifi cantly inhibited the formation of ulcers induced by the three different models, increased the GSH and GR levels and maintained the same levels of SOD and GPx of the sham group, inhibited MPO and MDA, did not produce signifi cant modifi cation in gastric juice content and showed increased COX-2 and EGF. BB exerts its gastroprotective activity, possibly, by increasing COX-2 and EGF expression and due to its possible antioxidant property.

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“…The w/w extraction yield was 8.23% (Dharmani et al, 2004). In a study on the 50% ethanol extract of Utleria salicifolia rhizomes (4.2%, w/w, yield), Rao et al (2004) reported a dosedependant ulcer protective effect both in gastric as well as duodenal lesions. The extract was assessed at 50-200 mg/kg per os twice daily during 5 days.…”

Section: Extractsmentioning

confidence: 99%