Gastroprotective effects of essential oil from Protium heptaphyllum on experimental gastric ulcer models in rats

Abstract

Peptic ulcers are a common disorder of the entire gastrointestinal tract, its etiology has not been completely elucidated. The basic physiopathological of peptic ulcers result from an imbalance between some endogenous aggressive factor and cytoprotective factors. The treatment of this disease is usually done with antacids or proton pump, but are currently being used plants derivated compounds. We evaluated the gastroprotective properties and its possible mechanisms of action of the essential oil from Protium heptaphyllum (Aubl.) Marchand, Burseraceae (BB). The formation of ulcers, were evaluated in three experimental models, through the induction of gastric lesions by ethanol, nonsteroidal anti-infl ammatory drugs and acetic acid. The mechanisms of action were evaluated through the pylorus ligature experiment, western blot, GSH, GR, SOD, GPx, MDA and MPO activities. BB signifi cantly inhibited the formation of ulcers induced by the three different models, increased the GSH and GR levels and maintained the same levels of SOD and GPx of the sham group, inhibited MPO and MDA, did not produce signifi cant modifi cation in gastric juice content and showed increased COX-2 and EGF. BB exerts its gastroprotective activity, possibly, by increasing COX-2 and EGF expression and due to its possible antioxidant property.

Effects of topical application of essential oil from resin of almescar (Protium heptaphyllum (Aubl.) Marchand) in experimentally induced skin wounds in rats

“…This observation was also described by Araujo et al (2011). In addition, animals had a body weight gain of 10% during the experimental period (mean body weight of 329.67g two weeks before the beginning and 362.57g on the last day).…”

“…Similar results were observed by Garros et al (2006) but on their research with Passiflora there were no differences between control and treatment groups. Apart of the anti-inflammatory effects, Araujo et al (2011) demonstrated the antioxidant effects of Protium due the action of monoterpenes. According to the authors, Protium reduces malondialdehyde (MDA) production, a final product of lipidic peroxidation.…”

“…Popularly, several pharmacological activities were attributed to the resin, such as tonic, stimulant, anti-ulcer, anti-inflammatory, healing, analgesic and expectorant (Aragão et al, 2006). Oliveira et al (2004) and Araujo et al (2011) described its gastroprotective activity, possibly, by increasing COX-2 and EGF expression and due to its possible antioxidant property.…”

Serotonin and histamine mediate gastroprotective effect of fluoxetine against experimentally-induced ulcers in rats

“…On the day of ulcer induction, access to water was stopped for 2 h (Ismail et al 2012). On Day 14, 30 min after the final IP injection of the various treatments/saline (Ji et al 2012), Group 1 rats were administered 1 ml saline per os, while rats in Groups II-IV were given 100 mg INDO/kg; 5 h later, the rats were euthanized by ether asphyxiation (Araujo et al 2011). In parallel, rats in Group V (Control 2) were administered 1 ml saline per os and those in Groups VI-VIII 5 ml/kg absolute alcohol; 1 h later, these rats were euthanized by ether asphyxiation (Vidya et al 2001).…”

Effect of Musa sapientum (Banana) on Indomethacin-Induced Gastric Mucosal Injury in Rats: Histological Study

“…-Indomethacin (Liometacen & Chiesi Farmaceutici) was purchased from the pharmacy in a form of powder in ampules of 50 mg. It was given orally dissolved in normal saline as a single dose of 100mg/kg (7) .…”