Antiulcer activity of the stem bark extract of <i>Entandrophragma angolense</i>

Njar, Vincent C.O.; Adesanwo, Julius K.; Makinde, J. M.; Taiwo, Olayombo

doi:10.1002/ptr.2650080111

Cited by 7 publications

(4 citation statements)

References 3 publications

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“…Using indomethacin as a 25 mg/mL indocid capsule (Merck, Sharp and Dohme, Canada) induced gastric mucosal ulcers at a dose of 40 mg/kg body weight in saline administered subcutaneously according to the methods described by Njar et al (1994Njar et al ( , 1995.…”

Section: Animalsmentioning

confidence: 99%

Antiulcerogenic effects of coconut (Cocos nucifera) extract in rats

Woyike

2008

Phytotherapy Research

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A warm water crude extract of coconut milk and a coconut water dispersion were investigated for their antiulcerogenic effects in male Wistar albino rats. Ulcers were induced in the male rats by subcutaneous administration of indomethacin (40 mg/kg) using standard procedures. The ulcer inhibition rate (UIR) was taken as a measure of the cytoprotection offered by test substances. Coconut milk (2 mL daily oral feeding) produced a stronger percentage (54%) reduction in the mean ulcer area than coconut water (39%). The effect of coconut milk was similar to the effect of sucralfate that reduced the mean ulcer area by 56% in this study. Sucralfate is a conventional cytoprotective agent. The results showed that coconut milk and water via macroscopic observation had protective effects on the ulcerated gastric mucosa. It is concluded that coconut milk offered stronger protection on indomethacin-induced ulceration than coconut water in rats.

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Section: Animalsmentioning

confidence: 99%

Antiulcerogenic effects of coconut (Cocos nucifera) extract in rats

Woyike

2008

Phytotherapy Research

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“…Gastric acid secretion responses to 1, histamine, and carbachol were carried according to the method of Ghosh (8). The air-dried pulverized stem bark (200 g) was extracted as previously described (1) to give a powdery crude extract (15 g). 5 g of the extract were chromatographed on a silica gel column (2.5 x 48cm), eluting with hexane/EtOAc mixtures of increasing polarity (5% EtOAc/hexane (400 ml), 15% EtOAc/hexarie (400m1), 30% EtOAc/hexane (200ml), 40% EtOAc/hexane (300m1),…”

Section: Pharmacological Testmentioning

confidence: 99%

Methyl Angolensate: The Antiulcer Agent of the Stem Bark ofEntandrophragma angolense

1995

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Methyl angolensate (1), the major compound isolated from the methanol extract of the stem bark of Entandrophragma angolense produced a dose-related inhibition of gastric ulceration, 40 mg/kg body weight (B.W.) being more effective than 40 mg/kg B.W. of propranolol. The highest dose used (80 mg/kg B.W.) completely inhibited gastric ulceration and significantly reduced gastric acidity (P < 0.05). Furthermore, 1 (40 mg/kg B.W.) significantly reduced gastric acid secretion induced by histamine (1.0 mg/kg B.W.) and carbachol (1.0 mg/kg B.W.). These results suggest that 1 produces its antiulcer activity by inhibition of gastric acid secretion.

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“…Entandrophragma angolense one of the Ivorian plants is used in traditional medicine to treat fever and as an analgesic against stomach upset and peptic ulcers, earache and hip pain [9]. Several studies have been carried out on the biological properties of bark extracts of this plant such as antiplasmodial activity [10], antiulcer activity [11]. A species of this genus, Entandrophragma utile has been studied for its antisickling property [12].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of the Effect of Aqueous Extract of Entandrophragma angolense and Vitamin B12 on Induced Hemolytic Anemia and Inflammation in the Wistar Rat

Adeoti

Yenon

Vanie

et al. 2019

AJBGMB

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Entandrophragma angolense is a plant of the family Meliaceae of African pharmacopoeia. It is used in traditional medicine as an analgesic and anti-inflammatory in cases of abdominal or hips pain. The aim of this study is to compare the effect of oral administration of aqueous extract of E. angolense and vitamin B12 on hemolytic induced anemia and inflammation in the rat. Anemia was induced by intraperitoneal administration of phenylhydrazine at the dose of 40 mg / kg / day for two days in 24 Wistar rats, followed by aqueous extract of E. angolense and vitamin B12 chosen as reference molecule administered orally to rats once a day for 28 days. A biological assessment on blood count, CRP and the study of secondary metabolites of the aqueous extract of E. angolense have been realized. The results obtained showed the existence of anemia characterized by a significant decrease (p <0.01) of the hemoglobin level of 42.80% ± 3.09 and red blood cells of 44.21% ± 3.16 in rats, and inflammation revealed by the significantly elevated CRP assay (p <0.05). The aqueous extract of E. angolense at the dose of 200 mg / kg increased significantly (p <0.001) the number of red blood cells and hemoglobin at the 4th week of treatment compared to the vitamin B12. In conclusion, the aqueous extract of the plant has an anti-inflammatory and anti-anemic effect. This double physiological action could come from the phytochemicals (flavonoids, saponins and alkaloids) contained in the extract.

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Antiulcer activity of the stem bark extract of Entandrophragma angolense

Cited by 7 publications

References 3 publications

Antiulcerogenic effects of coconut (Cocos nucifera) extract in rats

Antiulcerogenic effects of coconut (Cocos nucifera) extract in rats

Methyl Angolensate: The Antiulcer Agent of the Stem Bark ofEntandrophragma angolense

Comparative Study of the Effect of Aqueous Extract of Entandrophragma angolense and Vitamin B12 on Induced Hemolytic Anemia and Inflammation in the Wistar Rat

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