Antityrosinase and antimicrobial activities from Thai medicinal plants

Abstract

Various dermatological disorders and microbial skin infection can cause hyperpigmentation. Therefore, screenings for whitening and antimicrobial agents from Thai medicinal plants have been of research interest. Seventy-seven ethanol plant extracts were investigated for antityrosinase activity, eleven samples showed the tyrosinase inhibition more than 50 % were further preliminary screening for antimicrobial activity by agar disc diffusion and broth micro-dilution methods. Artocarpus integer (Thunb.) Merr. (Moraceae) root extract, which showed the potential of tyrosinase inhibition with 90.57 ± 2.93 % and antimicrobial activity against Staphylococcus aureus, S. epidermidis, Propionibacterium acnes and Trichophyton mentagophytes with inhibition zone as 9.10 ± 0.00, 10.67 ± 0.09, 15.25 ± 0.05 and 6.60 ± 0.17 mm, respectively was selected for phytochemical investigation. Three pure compounds were isolated as artocarpin, cudraflavone C and artocarpanone. And artocarpanone exhibited anti-tyrosinase effect; artocarpin and cudraflavone C also showed the potential of antibacterial activity against S. aureus, S. epidermidis and P. acnes with MIC at 2, 4 and 2 μg/ml, respectively and MBC at 32 μg/ml for these bacteria. So, these pure compounds are interesting for further study in order to provide possibilities of new whitening and antibacterial development. This will be the first report of phytochemical investigation of A. integer root.

Encapsulation artocarpanone and ascorbic acid in O/W microemulsions: Preparation, characterization, and antibrowning effects in apple juice

“…According to the increase in DE and a ⁄ values and the decrease in L ⁄ value normally associated with browning, all the results combined revealed that 0.01% Arto + 0.05% VcME and 0.01% Arto + 0.02% VcME could better inhibit the happening of browning for apple juices than ArtoME and VcME alone. Although inhibitory effect of Arto on tyrosinase has previously been reported in our previous study (Zheng et al, 2008) and others (Arung et al, 2006;Dej-Adisai et al, 2014;Wei et al, 2005), the mechanism of its browning inhibition is still unknown. The above findings suggested that browning inhibition of Arto was achieved possibly through a mechanism similar to that of 4-HR.…”

“…It was reported to have activities of antiinflammatory, antimicrobial, and inhibitory effect on melanin biosynthesis (Arung et al, 2006;Dej-Adisai et al, 2014;Wei et al, 2005). Our previous study revealed that Arto had strong tyrosinase inhibitory activity (Zheng et al, 2008).…”

“…Artocarpanone (Arto) was found in some Moraceous plants, such as Artocarpus heterophyllus, Artocarpus communis, and Artocarpus integer (Arung, Shimizu, & Kondo, 2006;Dej-Adisai, Meechai, Puripattanavong, & Kummee, 2014;Wei et al, 2005;Zheng, Cheng, To, Li, & Wang, 2008). It was reported to have activities of antiinflammatory, antimicrobial, and inhibitory effect on melanin biosynthesis (Arung et al, 2006;Dej-Adisai et al, 2014;Wei et al, 2005).…”

Antibacterial assay-guided isolation of active compounds fromArtocarpus heterophyllusheartwoods

“…Substitutions of an isoprenyl group on C-3, a 3-methyl-1-butenyl group on C-6, and a hydroxy group on C-2 0 for cycloartocarpin (1) and artocarpin (2) might be required for their antibacterial activity (Dej-adisai et al, 2013;Tsuchiya et al, 1996). Cyclization of the hydroxy group on C-2 0 with the isoprenyl group on C-3 for cycloartocarpin (1) resulted in a decrease of antibacterial activity.…”

Simultaneous HPLC Analysis of Three Flavonoids in the Extracts ofArtocarpus heterophyllusHeartwoods

“…1) from the heartwoods of A. heterophyllus. 6 Artocarpanone also possessed antiinflammatory activity and had an inhibitory effect on melanin biosynthesis 7,8 , while artocarpin possessed anticancer activity and inhibited neuraminidase 9,10 , while cycloartocarpin possessed antiplatelet activity.…”