Antitussives in the Treatment of Acute Transient Cough in Children

Korppi, Matti; Laurikainen, Kari; Pietikäinen, M; Silvasti, M

doi:10.1111/j.1651-2227.1991.tb11764.x

Cited by 53 publications

(39 citation statements)

References 4 publications

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“…Given the results of this investigation and the results of other related investigations, 8,9 it is important to evaluate whether the OTC availability of these substances is benign. For example, whereas the efficacy of DM has been uncertain, its potential for toxicity has not.…”

Section: Discussionmentioning

confidence: 96%

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Effect of Dextromethorphan, Diphenhydramine, and Placebo on Nocturnal Cough and Sleep Quality for Coughing Children and Their Parents

Paul¹,

Yoder

Crowell³

et al. 2004

Pediatrics

151

105

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ABSTRACT. Objectives. To determine whether the commonly used over-the-counter medications dextromethorphan and diphenhydramine are superior to placebo for the treatment of nocturnal cough and sleep difficulty associated with upper respiratory infections and to determine whether parents have improved sleep quality when their children receive the medications when compared with placebo.Methods. Parents of 100 children with upper respiratory infections were questioned to assess the frequency, severity, and bothersome nature of the nocturnal cough. Their answers were recorded on 2 consecutive days, initially on the day of presentation, when no medication had been given the previous evening, and then again on the subsequent day, when either medication or placebo was given before bedtime. Sleep quality for both the child and the parent were also assessed for both nights.Results. For the entire cohort, all outcomes were significantly improved on the second night of the study when either medication or placebo was given. However, neither diphenhydramine nor dextromethorphan produced a superior benefit when compared with placebo for any of the outcomes studied. Insomnia was reported more frequently in those who were given dextromethorphan, and drowsiness was reported more commonly in those who were given diphenhydramine.Conclusions. Diphenhydramine and dextromethorphan are not superior to placebo in providing nocturnal symptom relief for children with cough and sleep difficulty as a result of an upper respiratory infection. Furthermore, the medications given to children do not result in improved quality of sleep for their parents when compared with placebo. Each clinician should consider these findings, the potential for adverse effects, and the individual and cumulative costs of the drugs before recommending them to families. Pediatrics 2004;114:e85-e90. URL: http://www.pediatrics.org/cgi/content/full/114/ 1/e85; cough, upper respiratory infection, dextromethorphan, diphenhydramine, placebo.

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Section: Discussionmentioning

confidence: 96%

“…[8][9][10][11][12][13] Objective assessments of DM in adults with URI also have had conflicting results. [14][15][16] DPH is generally thought to be ineffective when compared with PL for the treatment of acute cough as a result of URIs, [17][18][19] but some reports contradict this belief.…”

mentioning

confidence: 99%

Effect of Dextromethorphan, Diphenhydramine, and Placebo on Nocturnal Cough and Sleep Quality for Coughing Children and Their Parents

Paul¹,

Yoder

Crowell³

et al. 2004

Pediatrics

151

105

View full text Add to dashboard Cite

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“…However, data on the efficacy of dextromethorphan in pediatric populations are limited, and in each case the study sample size is judged to be too small to have detected efficacy differences compared with placebo (Pavesi et al, 2001). Four published studies (Korppi et al, 1991;Paul et al, 2004a,b;Yoder et al, 2006) examined the antitussive effect of dextromethorphan on acute cough in children with acute URTI, although none showed any significant antitussive effects.…”

Section: B Dextromethorphanmentioning

confidence: 99%

Antitussive Drugs—Past, Present, and Future

et al. 2014

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“…Previous studies showed inconclusive results for the efficacy of cough medicines in the treatment of cold-related cough in adults and children, and it seems that high-quality research is still needed to provide evidence-based recommendations for herbal agents (6)(7)(8). There have been only four clinical trials that compared cough medicines with placebo in children (9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Zataria multiflora Extract Syrup and Diphenhydramine in the Treatment of Common Cold-Induced Cough in Children: A Double-Blind, Randomized, Clinical Trial

Hosseini¹,

Hossein²,

Amanati³

et al. 2016

Arch Pediatr Infect Dis

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Background: Management of cold-associated cough is a challenging aspect of supportive care for the common cold for pediatricians and parents worldwide. Herbal compounds have traditionally been used for the treatment of cold-related cough. Among these compounds, Zataria multiflora (ZM) has been found to be effective for cough relief. Objectives: The aim of this study is to compare a thyme mixture with diphenhydramine in the treatment of cold-related cough in a double-blind, randomized, clinical trial. Patients and Methods: A total of 52 pediatric patients (2 -12 years old) with common colds were included in the study. The patients were randomly divided into two treatment groups: one group received diphenhydramine compound and the other received ZM syrup, each for five days. The severity of cold-related symptoms and the efficacy of each drug were determined seven days later by asking the parents to complete a prepared questionnaire. sedation, sleepiness, a four-point scale of cough status, and a two-point scale of consumption convenience were also evaluated in these questionnaires. Results: Our results showed that sedation and sleepiness occurred in 30.8% and 19.2% of the patients in the diphenhydramine and ZM groups, respectively (P = 0.54). Also, 65.4% and 84.6% of the patients in the diphenhydramine and ZM groups, respectively, reported convenient usage (P = 0.10). The patients who received ZM syrup had significantly better outcomes (P = 0.036). Conclusions: Herbal compounds, such as ZM mixtures, are acceptably efficacious in cough relief with fewer adverse effects than chemical compounds in the treatment of cold-related cough, especially in infants and younger children.

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Antitussives in the Treatment of Acute Transient Cough in Children

Cited by 53 publications

References 4 publications

Effect of Dextromethorphan, Diphenhydramine, and Placebo on Nocturnal Cough and Sleep Quality for Coughing Children and Their Parents

Effect of Dextromethorphan, Diphenhydramine, and Placebo on Nocturnal Cough and Sleep Quality for Coughing Children and Their Parents

Antitussive Drugs—Past, Present, and Future

Comparison of Zataria multiflora Extract Syrup and Diphenhydramine in the Treatment of Common Cold-Induced Cough in Children: A Double-Blind, Randomized, Clinical Trial

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