Antitussive activity of an extracellular Rhodella grisea proteoglycan on the mechanically induced cough reflex

Nosálóvá, G; Capek, Peter; Matáková, Tatiana; Nosál, S; Flešková, Dana; Jurecek, Ludovit

doi:10.1016/j.carbpol.2011.08.058

Cited by 12 publications

(6 citation statements)

References 9 publications

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“…In our previous paper we have confirmed the antitussive effect of EPG-88 conjugate on a mechanically induced cough in the test system -non-anaesthetized cats [7]. Biopolymer showed a positive cough suppressing effect on laryngopharyngeal type of cough; however, the cough from tracheobronchial mucous area was slightly or not affected.…”

Section: Resultssupporting

confidence: 64%

“…Moreover, EPG possess a high water-binding capacity and due to a relative high carboxyl content it can participates in cation exchange processes. Mutual interactions of Rhodella EPG with mucous can be finally resulted in a decreasing not only mechanical but also chemical irritation of the airways and suppression of cough reflex [7]. It has been found that the reactivity of airways smooth muscle was not affected by biopolymer indicating that expectoration effect was not suppressed by its application.…”

Section: Resultsmentioning

confidence: 98%

“…Red alga Rhodella grisea has been shown to be appropriate candidate for above mentioned applications due to production of extremely viscous extracellular biopolymer [6]. Biological activity tests showed a positive antitussive effect of Rhodella biopolymer on mechanically induced cough mainly from laryngopharyngeal mucous area of the airways [7]. In consequence, the aim of the following paper is to verify the possible antitussive activity of Rhodella biopolymer on a chemically induced cough reflex in guinea pigs as a test system.…”

Section: Introductionmentioning

confidence: 98%

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Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex

Nosálóvá

Capek

Flešková

et al. 2011

International Journal of Biological Macromolecules

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Section: Resultssupporting

confidence: 64%

Section: Resultsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

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Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex

Nosálóvá

Capek

Flešková

et al. 2011

International Journal of Biological Macromolecules

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“…In vivo (Ghosh et al, 2015;Nosáľová et al, 2012) Betulinic of inflammatory cytokines, including TNF-α, were decreased (Godse et al, 2016).…”

Section: Leaf Methanol Extract Antioxidantmentioning

confidence: 95%

A comprehensive review on the phytoconstituents and biological activities of Nyctanthes arbor-tristis L.

Dewi¹,

Fakhrudin²,

Wahyuono³

2022

j app pharm sci

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Nyctanthes arbor-tristis (NAT) is one of the Indonesian herbal medicines which belongs to the genus Nyctanthes and the Oleaceae family. Traditionally, NAT is used to reduce fever and pain and treat hemorrhoids, irregular menstruation, cough, and asthma. This review article aimed to examine the phytoconstituents and pharmacological activities of NAT from different plant parts. The literature search was conducted through PubMed and Google Scholar databases. Our literature study showed that NAT has various secondary metabolites, such as steroids, terpenes, flavonoids, phenol, iridoid glycosides, and alkaloids. These compounds are distributed in the leaves, seeds, flowers, and stem bark. Different chemical structures of secondary metabolites are present in each plant part, and each demonstrates distinct pharmacological activities. The most common activities found in the literature are antimicrobial, analgesic, antiinflammatory, antidiabetic, antioxidant, hepatoprotective, antitussive, and antimalarial activities. Although this plant offers a promising source for drug discovery, the pharmacological and phytochemical data are still limited. Further studies are needed to explore the potency of NAT as natural products benefiting human health.

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“…Finally, some other biological activities have been demonstrated, such as the specific reduction of the frequency and intensity of the cough without avoiding the expectoration by the EPS of Rhodella grisea [ 228 ]. This interesting effect was also noticed for the EPS from Nostoc sp., orally administered to guinea pigs.…”

Section: Applicationsmentioning

confidence: 99%

Exopolysaccharides from Microalgae and Cyanobacteria: Diversity of Strains, Production Strategies, and Applications

Laroche

2022

Marine Drugs

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Microalgae and cyanobacteria are photosynthetic organisms that can produce/accumulate biomolecules with industrial interest. Among these molecules, EPSs are macromolecular polysaccharidic compounds that present biological activities and physico-chemical properties, allowing to consider their valorization in diverse commercial markets, such as cosmetic, therapeutic, nutraceutic, or hydrocolloids areas. The number of microalgae and cyanobacteria strains described to produce such EPSs has increased in recent years as, among the 256 producing strains gathered in this review, 86 were published in the last 10 years (~33%). Moreover, with the rise of research on microalgae EPSs, a variety of monosaccharides compositions have been discovered, highlighting the versatility of these organisms. If some production strategies can be applied to increase EPS production yields, it appears that case by case studies are needed to promote EPS synthesis by a strain, as many responses exist. This paper proposes an up-to-date state of the art of the diversity of microalgae and cyanobacteria EPS-producing strains, associated to the variability of compositions. The strategies for the production and extraction of the polymers are also discussed. Finally, an overview of the biological activities and physico-chemical properties allow one to consider their use on several commercial markets.

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Antitussive activity of an extracellular Rhodella grisea proteoglycan on the mechanically induced cough reflex

Cited by 12 publications

References 9 publications

Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex

Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex

A comprehensive review on the phytoconstituents and biological activities of Nyctanthes arbor-tristis L.

Exopolysaccharides from Microalgae and Cyanobacteria: Diversity of Strains, Production Strategies, and Applications

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