Antitumour Lymphocyte Responses

Prognostic Performance of Pretreatment Systemic Immune-Inflammation Index in Women with Epithelial Ovarian Cancer

“…Neutrophils promote the proliferation and metastasis of tumor cells, aid the undermining of immune surveillance, repair the senescent cancer cell and suppress T cell activation to promote immune evasion [ 19 ]. Platelets protect circulating tumor cells from shearing forces in arteries, allowing them to shift from epithelial to mesenchymal state [ 4 ] while lymphocytes demonstrate anti-tumor activities of mediating adaptive and non-adaptive immune responses by recognizing foreign antigenic determinants expressed on tumor cells and mounting an effective, tumor-specific immune response toward these determinants [ 20 ].…”