Psychoneuroimmunology. Implications for oncology?

Bovbjerg, Dana H.

doi:10.1002/1097-0142(19910201)67:3+<828::aid-cncr2820671413>3.0.co;2-a

Cited by 39 publications

(17 citation statements)

References 37 publications

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“…The presence of a higher rate of complications, which is a more objective variable, may be explained by 2 possible mechanisms. One is the direct effect of stress hormones observed in the anxious patients (12). The other is the immunosuppressive effect of psychological status (7,12).…”

Section: Discussionmentioning

confidence: 97%

“…One is the direct effect of stress hormones observed in the anxious patients (12). The other is the immunosuppressive effect of psychological status (7,12). Unfortunately, we did not measure any of the stress hormones and immune parameters.…”

Section: Discussionmentioning

confidence: 99%

“…It was shown that depressed or stressed breast cancer patients have poorer survival than the ones who are not stressed (6). Bovbjerg hypothesized that psychosocial factors have an influence on immune function, which could provide an association between psychosocial factors and cancer prognosis (12). In line with this, Larson and assoc.…”

Section: Discussionmentioning

confidence: 99%

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The Effect of the Psychological Status of Breast Cancer Patients on the Shortterm Clinical Outcome after Mastectomy

Törer

Nursal

Çalışkan

et al. 2010

Acta Chirurgica Belgica

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to analyze the effect of anxiety and depression on the postoperative complications and length of hospitalization of patients with breast cancer. Beck's Depression Inventory (BDI) and Hospital Anxiety and Depression Scale (HADS) were filled out by the patients pre-operatively. Patients were asked to rate their pain by the visual analogue scale (VAS) after surgery. Age, seroma volume, day of drain withdrawal, complications, and pathological stages were noted. The median age of 49 patients with the diagnosis of breast cancer was 51 (36-80). There was a significant correlation between the pain score and Beck, HADS, HADS (anxiety) and HADS (depression) (8 hours ; p = 0.021, 0.001, 0.004, 0.005 and 24 hours ; p = 0.005, 0.012, 0.006, 0.120). The mean HADS depression score in those patients with complications was 9.1 +/- 4.2 and that of patients with no complications was 6.6 +/- 3.1 (p = 0.047). The mean hospital stay of patients with a normal HADS score (< 19) was 2.9 +/- 1.1 days, whilst that of patients with an abnormal HADS score was 3.8 +/- 1.2 days (p = 0.016). Patients with abnormal HADS anxiety and abnormal HADS (total) scores had an earlier stage of breast cancer (p = 0.077, p = 0.063). The psychological status of breast cancer patients effects their postoperative recovery period and it is easy to diagnose these patients by some brief questionnaires.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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The Effect of the Psychological Status of Breast Cancer Patients on the Shortterm Clinical Outcome after Mastectomy

Törer

Nursal

Çalışkan

et al. 2010

Acta Chirurgica Belgica

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“…These changes may be accompanied or followed by poor compliance to medical regimens, increases in negative health behaviors and decreases in positive health behaviors, which may combine with physiologic responses to stress to encourage local and metastatic disease progression. A major challenge in psychosocial intervention research in oncology is finding ways to minimize and account for the confounding effects of different disease characteristics and cancer treatments on biobehavioral indicators and clinical outcomes (Bovjberg, 1991; van der Pompe, Antoni & Heijnen, 1998). Using the example of breast cancer, differences in clinicopathological characteristics can have prognostic significance (stage, HER2-neu+/−, ER/PR+/−) (Biganzoli & Boracchi, 2004; Woodward, Storm, Tucker, McNeese, 2003), and in at least one trial, were found to moderate the effects of a psychological intervention on clinical outcomes (Spiegel et al, 2007).…”

Section: Psychosocial Intervention Effects On Psychological Adapmentioning

confidence: 99%

Psychosocial intervention effects on adaptation, disease course and biobehavioral processes in cancer

Antoni

2013

Brain, Behavior, and Immunity

149

131

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A diagnosis of cancer and subsequent treatments place demands on psychological adaptation. Behavioral research suggests the importance of cognitive, behavioral, and social factors in facilitating adaptation during active treatment and throughout cancer survivorship, which forms the rationale for the use of many psychosocial interventions in cancer patients. This cancer experience may also affect physiological adaptation systems (e.g., neuroendocrine) in parallel with psychological adaptation changes (negative affect). Changes in adaptation may alter tumor growth-promoting processes (increased angiogenesis, migration and invasion, and inflammation) and tumor defense processes (decreased cellular immunity) relevant for cancer progression and the quality of life of cancer patients. Some evidence suggests that psychosocial intervention can improve psychological and physiological adaptation indicators in cancer patients. However, less is known about whether these interventions can influence tumor activity and tumor growth-promoting processes and whether changes in these processes could explain the psychosocial intervention effects on recurrence and survival documented to date. Documenting that psychosocial interventions can modulate molecular activities (e.g., transcriptional indicators of cell signaling) that govern tumor promoting and tumor defense processes on the one hand, and clinical disease course on the other is a key challenge for biobehavioral oncology research. This mini-review will summarize current knowledge on psychological and physiological adaptation processes affected throughout the stress of the cancer experience, and the effects of psychosocial interventions on psychological adaptation, cancer disease progression, and changes in stress-related biobehavioral processes that may mediate intervention effects on clinical cancer outcomes. Very recent intervention work in breast cancer will be used to illuminate emerging trends in molecular probes of interest in the hope of highlighting future paths that could move the field of biobehavioral oncology intervention research forward.

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“…Accordingly, psychological or behavioral factors and stress can influence many physiological and pathological disease outcomes including cancer (Andersen et al 1994, Andersen et al 1998Bovbjerg 1991;Levy et al 1985Levy et al , 1987Spiegel and Kato 1996), as carefully examined for the last three decades. Research over the past 30 years in the field of psychoneuroimmunology (PNI) and multiple clinical and epidemiological studies have given much contribution to the understanding of the effect of psychological stress on human diseases, with particular emphasis on cancer related to suppressed immune responses to tumors and stress-induced alterations in the tumor microenvironment.…”

Section: Introductionmentioning

confidence: 99%

Psychological stress and cancer

Soung

Kim

2015

J Anal Sci Technol

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Psychological or psychosocial stress has been emerging as one of the key factors associated with cancer initiation, growth, and metastasis. Accumulating data, however, has mainly focused on cancer progression due to the inconsistent results of cancer etiology caused by emotional stress. Depression is closely linked to stress and induces hypothalamic-pituitary-adrenal (HPA) axis activation as well as sympathetic nervous system (SNS) down to immune cell surveillance. This review briefly describes the activation of neuroendocrine system by psychological stress/ depression and its effect on cancer occurrence and metastasis, which may be useful for the design of new cancer treatments.

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Psychoneuroimmunology. Implications for oncology?

Cited by 39 publications

References 37 publications

The Effect of the Psychological Status of Breast Cancer Patients on the Shortterm Clinical Outcome after Mastectomy

The Effect of the Psychological Status of Breast Cancer Patients on the Shortterm Clinical Outcome after Mastectomy

Psychosocial intervention effects on adaptation, disease course and biobehavioral processes in cancer

Psychological stress and cancer

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