Antitumour Activity of the Microencapsulation of <i>Annona vepretorum</i> Essential Oil

Bomfim, Larissa M.; Menezes, Leociley Rocha Alencar; Rodrigues, Andréa Maria dos Santos; Dias, Rosane Borges; Rocha, Clarissa Araújo Gurgel; Soares, Milena Botelho Pereira; Neto, Albertino Freitas Santana; Nascimento, Magaly P.; Campos, Adriana; Silva, Lidércia C. R. C. e.; Costa, Emmanoel V.; Bezerra, Daniel P.

doi:10.1111/bcpt.12488

Cited by 51 publications

(29 citation statements)

References 19 publications

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“…The activity was remarkable also against breast carcinoma and melanoma cell lines with IC 50 values ranging from 1.57 lg/ml of E. campestre essential oil on A375 cells to 5.32 lg/ml of E. amethystinum essential oil on MDA-MB 231 cells. [52] To our knowledge, data reporting the cytotoxic activity of ledol are missing. [48] Therefore, the essential oils obtained from E. amethystinum and E. campestre present a promising potential as sources of cytotoxic drugs.…”

Section: Chemical Composition Of Essential Oilsmentioning

confidence: 99%

Cytotoxic Essential Oils from Eryngium campestre and Eryngium amethystinum (Apiaceae) Growing in Central Italy

Cianfaglione

Blomme

Quassinti

et al. 2017

Chemistry & Biodiversity

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Eryngium campestre and E. amethystinum are thorny herbs belonging to the Apiaceae family and spontaneously growing in stony pastures and dry meadows, preferentially on calcareous substrates. In the Mediterranean countries, these plants have been used as a food or traditional remedies to treat various ailments. In the present work, we have analyzed the chemical composition of the essential oils distilled from the aerial parts by GC-FID and GC/MS, and evaluated their cytotoxic effects on a panel of human cancer cells, namely A375 (human malignant melanoma), MDA-MB 231 cells (human breast adenocarcinoma), and HCT116 cells (human colon carcinoma), by the MTT assay. Furthermore, the Eryngium essential oils were evaluated for antioxidant and acetylcholinesterase (AChE) activities. The two essential oils were rich in sesquiterpene hydrocarbons, with germacrene D as the major compound, accompanied by allo-aromadendrene, β-elemene, spathulenol, and ledol. They turned out to be highly cytotoxic on the tumor cells, with IC values (1.65 - 5.32 and 1.57 - 2.99 μg/ml for E. amethystinum and E. campestre, respectively) comparable or close to those of the anticancer drug cisplatin. The E. amethystinum essential oil exhibited a moderate antioxidant activity, whereas that of E. campestre a weak AChE inhibition.

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Section: Chemical Composition Of Essential Oilsmentioning

confidence: 99%

Cytotoxic Essential Oils from Eryngium campestre and Eryngium amethystinum (Apiaceae) Growing in Central Italy

Cianfaglione

Blomme

Quassinti

et al. 2017

Chemistry & Biodiversity

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“…In vitro cytotoxic effects of A. vepretorum leaf essential oil was evaluated against B16-F10, Hep G2, K562, and HL-60 cells, with IC 50 values ranging from 6.14 to 10.60 g/mL against HL-60 and Hep G2, respectively. 16 Spathulenol, bicyclogermacrene, (E)-␤-ocimene, ␣-phellandrene, o-cymene, germacrene D, and ␣-pinene were identified as major compounds. Spathulenol exhibited the highest inhibitory activity against K562 cells (IC 50 = 3.79 g/mL), whereas ␣-phellandrene and ␣-pinene exhibited the highest activity against B16-F10 (IC 50 = 15.44 and 11.46 g/mL, respectively).…”

Section: Essential Oil From Annona Speciesmentioning

confidence: 98%

“…In vitro cytotoxic effects of A. vepretorum leaf essential oil was evaluated against B16‐F10, Hep G2, K562, and HL‐60 cells, with IC 50 values ranging from 6.14 to 10.60 μg/mL against HL‐60 and Hep G2, respectively . Spathulenol, bicyclogermacrene, ( E )‐β‐ocimene, α‐phellandrene, o ‐cymene, germacrene D, and α‐pinene were identified as major compounds.…”

Section: Essential Oil From Annona Speciesmentioning

confidence: 99%

Annona species (Annonaceae): a rich source of potential antitumor agents?

Tundis

Xiao

Loizzo

2017

Annals of the New York Academy of Sciences

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Plants have provided the basis of traditional medicine systems throughout the world for thousands of years and continue to yield molecules for new remedies. We analyzed studies published from 2009 to 2016 on the Annona species (Annonaceae), including A. coriacea, A. crassifolia, A. hypoglauca, A. muricata, A. squamosa, A. sylvatica, and A. vepretorum, as sources of potential antitumor agents. Here, we report and discuss the mechanisms of action and structure-activity relationships of the most active Annona constituents. Annonaceous acetogenins are one of the most promising classes of natural products, owing to their potential antitumor activity. However, their neurotoxicity should not be underestimated.

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“…There are scientific evidences that inclusion complexation with CDs improves the pharmacological effects of EOs or their components [28,32,33]. For instance, the complexation of Hyptis pectinata L. EO with β-CD improved its analgesic effect in a mice model [34].…”

Section: Interaction Between Phytochemicals and Cyclodextrinsmentioning

confidence: 99%

“…For instance, the complexation of Hyptis pectinata L. EO with β-CD improved its analgesic effect in a mice model [34]. Also Bomfim et al observed that β-CD complexation increased in vivo tumor growth inhibition capacity of Annona vepretorum EO [32]. Recently, Lima et al reviewed the preclinical and clinical studies published on complexes between CDs and terpenes [33].…”

Section: Interaction Between Phytochemicals and Cyclodextrinsmentioning

confidence: 99%

Interactions between Bio-Based Compounds and Cyclodextrins

Medronho¹,

Gonçalves²,

RaquelRodríguez-Solana³

et al. 2018

Cyclodextrin - A Versatile Ingredient

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Bio-based compounds, such as "green" surfactants and phytochemicals, are regarded as future sustainable resources for a vast range of applications in a modern society increasingly demanding economical, social, and environmental awareness. Natural compounds from plants (phytochemicals) are very sought by the pharmaceutical, cosmetic, and food industries. On the other hand, the growing interest in "green" surfactants (e.g., carbohydrate-based) is due to, inter alia, their preparation from renewable raw materials, ready biodegradability, and biocompatibility, among other reasons of fundamental, practical, economical, and environmental orders. Despite the wide range of potential applications of these bio-based compounds, their practical use is still limited due to many reasons such as poor aqueous solubility, volatility, reactivity, etc. Generally, when complexed with cyclodextrins, these biobased compounds enhance considerably their performance and potential applications. Thus, this chapter aims at recalling some general fundamental aspects of phytochemicals and "green" surfactants, such as structure, function, and applications. In addition, their interactions with cyclodextrins are discussed from a physicochemical point of view with special focus on the techniques, mathematic modeling, and thermodynamic parameters (e.g., interactions, stoichiometries, association constants, etc.).

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Antitumour Activity of the Microencapsulation of Annona vepretorum Essential Oil

Abstract: Annona vepretorum Mart.

Cited by 51 publications

References 19 publications

Cytotoxic Essential Oils from Eryngium campestre and Eryngium amethystinum (Apiaceae) Growing in Central Italy

Cytotoxic Essential Oils from Eryngium campestre and Eryngium amethystinum (Apiaceae) Growing in Central Italy

Annona species (Annonaceae): a rich source of potential antitumor agents?

Interactions between Bio-Based Compounds and Cyclodextrins

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