Antitumour activity of Bauhinia variegata on Dalton’s ascitic lymphoma

Balasubramanian, Ravikumar; Jayakar, B.; Murugesh, N

doi:10.1016/s0378-8741(03)00264-2

Cited by 84 publications

(64 citation statements)

References 6 publications

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“…Elevated levels of serum enzymes are indicative of cellular leakage and loss of functional integrity of cell membrane in the liver [9]. A similar significant decrease in AST, ALT, and ALP was observed by Santhi and Annapoorani [10] by the administration of silymarin to carbon tetrachloride (CCl 4 ) induced hepatotoxicity in mice. Heba et al [11] also reported that rats fed with powder of Ziziphus spina-christi fruit decrease the activities of AST, ALT, and ALP in CCl 4 induced rats in a dose-dependent manner.…”

Section: Discussionsupporting

confidence: 53%

Anticancer Activity of Plant Protein Against Dalton’s Lymphoma Ascites Tumor Cell Lines

Srilatha¹,

Santhi²,

Annapurani³

2016

Asian J Pharm Clin Res

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Objective: Tabernaemontana divaricata (Td) is commonly used plants for the treatment of inflammatory, anticancer, and diabetics. The main objective of this study is to assess the antitumor and antioxidant activity of Td in mice model. Methods:Antitumor activity of TdPf extract (52 µg/ml) is evaluated against Dalton's lymphoma ascites (DLA) tumor mice. After 24 hrs of tumor inoculation, the extract is administered daily for 15 and 60 days. After administration of the lost dose followed by 18 hrs fasting, mice are sacrificed for observation of antitumor activity. Antitumor activity is assessed by monitoring the liver marker enzyme, lipid peroxidation effect on antioxidant enzyme levels, and histopathological evidence. Results:The results showed that the protein extract of Td animals restored the antioxidant enzymes when compared to the mice of the DLA control group. Conclusion:The findings indicate that the extract of plant protein has antitumor activity by preventing the lipid peroxidation and thereby promoting the antioxidant systems in DLA induced mice. And hence, it is evident that these extract could be a natural anticancer agent for the human health.

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Section: Discussionsupporting

confidence: 53%

Anticancer Activity of Plant Protein Against Dalton’s Lymphoma Ascites Tumor Cell Lines

Srilatha¹,

Santhi²,

Annapurani³

2016

Asian J Pharm Clin Res

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“…Species of the same genus such as B. galpinii, B. purpurea (Codington et al, 1975) and B. variegata (Rajkapoor et al, 2003) have been described as antimutagenic.…”

Section: Discussionmentioning

confidence: 99%

Determining the genotoxicity of an aqueous infusion of Bauhinia monandra leaves

Macêdo¹,

Sisenando²,

Queiroz³

et al. 2008

Rev. bras. farmacogn.

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“…Percentage of cytotoxicity was calculated by the following formula. % dead cells = Number of dead cells/Sum of dead cells and living cell × 100 (Rajkapoor et al, 2003).…”

Section: Trypan Blue Cell Exclusion Methodsmentioning

confidence: 99%