Antitumor platinum(IV) derivatives of oxaliplatin with axial valproato ligands

Cellular trafficking, accumulation and DNA platination of a series of cisplatin-based dicarboxylato Pt(IV) prodrugs

“…A similar result was recently obtained during the treatment of multicellular tumor spheroids with complexes 1-4 [40]. This suggests that sequestration inside cells, possibly in some lipophilic subcellular compartments, may be not per se a negative effect on the antiproliferative activity [70,71]. Thus, the most lipophilic complexes of the title series appear to be ideally suited for bypassing cisplatin resistance, when it relies on reduced cellular accumulation [72].…”

Platinum(iv) oxaliplatin–peptide conjugates targeting memHsp70+ phenotype in colorectal cancer cells

“…Keppler and coworkers developed an oxaliplatin Pt(IV) TAT-(YGRKKRRQRRR) cell penetrating peptide conjugate 19 and Gibson et al a Pt(IV) prodrug conjugate of the histone deacetylase inhibitor, valproic acid (VPA), 15 for example, Fig. 1.…”

Half-Sandwich Ru(II) Halogenido, Valproato and 4-Phenylbutyrato Complexes Containing 2,2′-Dipyridylamine: Synthesis, Characterization, Solution Chemistry and In Vitro Cytotoxicity

“…Both the aromatic rings of the dpa ligand form the dihedral angle of 37.00 (8) • , while the dihedral angles between theses rings and p-cymene ring equal 29.46 (8) • (formed by the ring containing the N1 atom) and 27.40 (8) • (formed by the ring containing the N1A atom). The crystal structure of the complex 3 is stabilized by a variety of non-covalent contacts of the N-H···F and C-H···F types (Supplementary Materials Table S1 and Figure S1).…”