1983
DOI: 10.1007/bf00046907
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Antitumor monoclonal antibodies for radioimmunodetection of tumors and drug targeting

Abstract: Developments in hybridoma technology leading to the production of monoclonal antibodies recognizing tumor-associated antigens are providing new approaches for the radioimmunodetection of, and drug targeting to, metastases. These developments are illustrated in a series of studies on the in vivo localization of an antihuman-osteogenic sarcoma monoclonal antibody (791T/36) in human tumor xenografts maintained in immunodeprived mice. 131I-labelled 791T/36 antibody localized specifically in osteogenic sarcomas but… Show more

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Cited by 58 publications
(22 citation statements)
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“…Since the grafts are dependent on a parasitic blood supply until neovascularization occurs, they often contain some central areas of necrosis and fibrosis, with the clusters of viable parathyroid cells located peripherally. A similar histological pattern has been noted in other radiolocalization studies in tumor models (4,30).…”
Section: Discussionsupporting
confidence: 63%
See 1 more Smart Citation
“…Since the grafts are dependent on a parasitic blood supply until neovascularization occurs, they often contain some central areas of necrosis and fibrosis, with the clusters of viable parathyroid cells located peripherally. A similar histological pattern has been noted in other radiolocalization studies in tumor models (4,30).…”
Section: Discussionsupporting
confidence: 63%
“…Numerous investigators used monoclonal antibodies developed against human tumor cells to radioimage tumor xenografts, usually in nude mouse model systems (2)(3)(4)(5)(6)(7)(8)(9). However, most of these studies focused on poorly defined and often nonspecific tumor-associated antigens.…”
mentioning
confidence: 99%
“…[4][5][6][7][8] By the 1980s, new chemistries for radiolabeling proteins were being developed that greatly expanded the possibilities for a variety of imaging and therapeutic radionuclides, and, importantly, murine monoclonal antibodies became available. [9][10][11][12][13][14][15][16][17][18][19] Hybridoma technology ultimately ushered in a new age of molecular engineering that has revolutionized the applications of antibodies and biologics alike. Murine monoclonal antibodies were chimerized and then humanized to reduce immunogenicity.…”
mentioning
confidence: 99%
“…For example, tumour growth was accompanied by a linear uptake of 1251-labelled monoclonal antibody (MoAb) in a murine human tumour system while the antigen of that model was not detected in the circulation (Baldwin & Pimm, 1983). Enlargement of tumours was accompanied by a measurable decrease in tumour concentration of "3'I-MoAb.…”
mentioning
confidence: 99%